A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19Article Published on 2020-10-152022-10-04 Journal: Nature Communications [Category] MERS, SARS, 신약개발, 임상, 진단, 치료법, 치료제, [키워드] A549 cell anti-infective drug anti-infective drugs Antiviral antivirals approved can be used Cell culture clinically Concentration Concordance coronavirus coronavirus disease COVID-19 evaluate expressing facilitate High-throughput screening human ACE2 receptor identify inactive Infection inhibitor neutralization neutralizing antibody patient sera plaque reduction neutralization platform PRNT replicate SARS-CoV-2 selective Serological testing severe respiratory syndrome Vaccine wild-type virus [DOI] 10.1038/s41467-020-19055-7 PMC 바로가기 [Article Type] Article
Evaluation of Oxygenation in 129 Proning Sessions in 34 Mechanically Ventilated COVID-19 PatientsOriginal Research Published on 2020-09-302022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, SARS, [키워드] Analysis ARDS benefit characteristics of patient Compliance Concordance COVID-19 decrease develop early stage Efficacy feature fraction hypoxaemia intensive care International Intervention mechanically ventilated National Oxygen requirement Oxygenation Patient patients PF ratio Prevalence prone prone positioning proning protocol question reduced reported respiratory Retrospective analysis SARS-CoV-2 SARS-COV-2 infection severe ARDS severity single center Student’s t -test survival Trial United Kingdom utility Ventilated Ventilation was recorded were assessed [DOI] 10.1177/0885066620955137 PMC 바로가기 [Article Type] Original Research
Safety measures for COVID-19: a review of surgical preparedness at four major medical centres in Saudi ArabiaReview Published on 2020-09-052022-10-28 Journal: Patient Safety in Surgery [Category] COVID-19, [키워드] anaesthesia Care Concordance coronavirus disease COVID-19 COVID-19 pandemic develop global pandemic guideline Health healthcare Healthcare system hospital implementation include infection control intensive care management measure Operating room pandemic Patient Prevent required Safety measure Saudi Arabia Simulation surgery surgical Transmission undergo with COVID-19 [DOI] 10.1186/s13037-020-00259-1 PMC 바로가기 [Article Type] Review
Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New ZealandMicrobiology Published on 2020-09-032022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] antibody Antigen binding calculated clinician Cohort Collaborative effort Concordance country COVID-19 COVID-19 pandemic COVID-19 patient Critical cut-off detect determine diagnostic reagent diagnostics effective vaccine ELISA hospital IgG ELISA immune response immunoassay Infection Interaction International investigated lockdown neutralising Neutralising Antibodies neutralising antibody New notable one individual overlap Patient PCR-confirmed COVID-19 patient PCR-negative positive produced quantified RBD reagent Receptor binding domain respiratory infection respiratory symptom Result SARS-CoV-2 SARS-CoV-2 patient Scientific community sera Serological assay serology seropositive serum antibody specificity Spike protein sVNT Symptom symptom onset symptomatic Transmission Travel utility viral neutralisation was used with COVID-19 [DOI] 10.7717/peerj.9863 PMC 바로가기 [Article Type] Microbiology
Comparison of SARS-CoV-2 detection from nasopharyngeal swab samples by the Roche cobas 6800 SARS-CoV-2 test and a laboratory-developed real-time RT-PCR testRoche cobas 6800 SARS-CoV-2 검사와 연구소에서 개발한 실시간 RT-PCR 검사에 의한 비인두 면봉 검체의 SARS-CoV-2 검출 비교Article Published on 2020-09-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis analyzed assays center Chain Reaction clinical clinical laboratories Concordance Control coronavirus Coronavirus-2 cycle Cycle threshold values disease control evaluated expand Factors GraphPad Prism GraphPad Prism 8 highlighting Inconclusive Infection limit of detection medium Mount Sinai Mount Sinai Health System Nasopharyngeal swab nasopharyngeal swab sample nasopharyngeal swabs platform polymerase chain reaction positive prevention primer primer sequences Prism protocol real-time RT-PCR test reported respiratory Reverse transcription-polymerase chain reaction RNA RNA extraction Roche Roche Diagnostics routine clinical care SARS SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 test severe acute respiratory syndrome Coronavirus statistical analysis submitted subsequent System tested threshold value Transport transport medium Universal Transport Medium was performed [DOI] 10.1002/jmv.25988 PMC 바로가기 [Article Type] Article
Diagnostic performance of initial blood urea nitrogen combined with D-dimer levels for predicting in-hospital mortality in COVID-19 patientsResearch article Published on 2020-09-012022-10-05 Journal: International journal of antimicrobial agents [Category] SARS, 진단, [키워드] 95% CI Admission analysed Analysis appear Blood urea nitrogen Clinical characteristics Combination Concordance coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical D-dimer D-dimer level died discharged elevated groups high risk hospital identify in-hospital mortality increased mortality independent risk factor initial Kaplan–Meier analysis Mortality mortality rate multivariable Cox regression non-survivor Older operator Patient patients pneumonia case poor prognosis predictor risk sensitivity severe COVID-19 patients significantly higher specificity survivor Viral pneumonia [DOI] 10.1016/j.ijantimicag.2020.106110 [Article Type] Research article
Concordance of Chest CT and Nucleic Acid Testing in Diagnosing Coronavirus Disease Outside its District of Origin (Wuhan, China)Original Article Published on 2020-08-142022-10-31 Journal: Clinics [Category] COVID-19, MERS, SARS, [키워드] Abnormalities abnormality acid Admission analyzed asymptomatic patient Chest CT chest CT scan Chi-square collected Computed tomography Concordance consecutive patient consolidation coronavirus coronavirus disease COVID-19 CT finding CT findings CT scan CT scans determine diagnosing disease District enrolled Follow-up GGO GGOs ground-glass opacity hospital initial Laboratory manifestation Multiple nucleic acid nucleic acid test nucleic acid testing origin Patient patients positive result symptomatic patient Symptoms Testing with COVID-19 Wuhan, China [DOI] 10.6061/clinics/2020/e1910 PMC 바로가기 [Article Type] Original Article
Deep learning‐based survival analysis for brain metastasis patients with the national cancer databaseRadiation Oncology Physics Published on 2020-08-132022-10-30 Journal: Journal of Applied Clinical Medical Physics [Category] Coronavirus, MERS, SARS, [키워드] age Analysis assessment Brain brain metastasis breast cancer patient Cancer classical clinical setting clinically Concordance covariate Cox proportional hazard CPU database deep deep learning hormone receptor information machine learning Metastasis National Patient patient survival physician Predictive previous study Prognosis prognostic indicator provided random Result risk RPA shown statistically significant difference stereotactic radiosurgery survival Test the mean treatment regimen was used were used [DOI] 10.1002/acm2.12995 PMC 바로가기 [Article Type] Radiation Oncology Physics
SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent?Research Article Published on 2020-08-052022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Amy can be used Cepheid Concordance coronavirus 2 COVID-19 detect diagnosis of COVID-19 Direct flexible global pandemic Healthcare systems help in viral Laboratory media medium MRSA nasal nasal swab Nasopharyngeal swab Patient positive respiratory respiratory viral Result SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 PCR testing SARS-CoV2 Swab swab sample swabs transport medium Universal Universal Transport Medium widespread [DOI] 10.1371/journal.pone.0237127 PMC 바로가기 [Article Type] Research Article
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by Mass Spectrometry질량분석법을 통한 중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 검출Article Published on 2020-08-042022-08-13 Journal: Viruses [Category] MERS, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification amplified analyzed assays Chain Reaction comparable Concordance coronavirus coronavirus 2 COVID19 detect detection faster gold gold standard hands initial mass mass spectrometry MS test system nasopharyngeal swabs outbreak Patient PCR polymerase chain polymerase chain reaction positive protocol real-time reverse transcriptase Real-time reverse transcriptase polymerase chain reaction respiratory Result reverse transcriptase Reverse transcriptase polymerase chain reaction Ribonucleic acid RNA rRT-PCR SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus Spectrometry tested Viral viral ribonucleic acid Viral RNA viral spread [DOI] 10.3390/v12080849 PMC 바로가기 [Article Type] Article