Tautomeric and non-tautomeric N-substituted 2-iminobenzimidazolines as new lead compounds for the design of anti-influenza drugs: An in vitro studyArticle Published on 2016-11-152023-06-23 Journal: Bioorganic & Medicinal Chemistry [Category] 신종인플루엔자, [키워드] 2-Acylaminobenzimidazoles 2-Iminobenzimidazolines 2-Thioureidobenzimidazoles antiviral activity cytotoxicity influenza virus. [DOI] 10.1016/j.bmc.2016.09.036 PMC 바로가기
Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensisArticle Published on 2015-12-242023-06-24 Journal: Journal of ethnopharmacology [Category] 신종인플루엔자, [키워드] Anti-H1N1 virus Baicalein (PubChem CID: 5281605) Baicalin (PubChem CID: 64982) chrysin (PubChem CID: 5281607) cytotoxicity Effective components Nrf2 activation oroxylin A (PubChem CID: 5320315) Scutellaria baicalensis Wogonin (PubChem CID: 5281703). [DOI] 10.1016/j.jep.2015.11.018 PMC 바로가기
Performance evaluation of Puritan® universal transport system (UniTranz-RT™) for preservation and transport of clinical virusesComparative Study Published on 2015-10-012023-06-01 Journal: Journal of medical virology [Category] 두창, 수두, 홍역, [키워드] cytotoxicity pre-analytics Transport media UniTranz-RT™ UVT viruses. [DOI] 10.1002/jmv.24236 PMC 바로가기 [Article Type] Comparative Study
Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infectionOriginal Research Published on 2015-09-012023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] Chikungunya cytotoxicity NK cell NKT-like cell perforin [DOI] 10.3389/fmicb.2015.00895 PMC 바로가기 [Article Type] Original Research
Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replicationResearch Article Published on 2014-01-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Nigella sativa Rhodiola rosea Sambucus nigra Anti-viral drugs bronchitis Cell compounds Concentration coronavirus Cytopathic effect cytotoxicity derivative determined different Effect electron microscopy highest IBV infected cell Infection Infectious Bronchitis Virus inhibit magnitude mechanism of action membrane MOI multiplicity of infection Nigella Sativa non-infectious other coronavirus pathogenic plant Plaque assay Prevent protocol quantified reduced Replication Result Rhodiola Safe Sambucus solvent staining suggested supernatant tested tissue transmission electron microscopy treat treated Treatment trypan blue staining vaccination Vero Cell vesicles viral titer virion virus virus inhibition virus titer viruses [DOI] 10.1186/1746-6148-10-24 PMC 바로가기 [Article Type] Research Article
Peptides Corresponding to the Predicted Heptad Repeat 2 Domain of the Feline Coronavirus Spike Protein Are Potent Inhibitors of Viral InfectionResearch Article Published on 2013-12-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Anti-viral Antiviral effect antiviral efficacy caused clinically Concentration coronavirus Coronavirus infection cytotoxicity demonstrated effective Efficacy evaluated exhibiting Feline infectious peritonitis FIVE heptad repeat IFN-α immune-mediated disease Infection inhibit inhibited Interferon-α MTT overlapping peptide performed plaque potent reduction Repeat Result selected sequence spike synergistic the spike protein therapy viral replication [DOI] 10.1371/journal.pone.0082081 PMC 바로가기 [Article Type] Research Article
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicityArticle Published on 2013-08-122023-06-23 Journal: Bioorganic & Medicinal Chemistry [Category] 신종인플루엔자, [키워드] antivirals Camphor cytotoxicity genotoxicity Imine derivatives Influenza [DOI] 10.1016/j.bmc.2013.08.014 PMC 바로가기 [Article Type] Article
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatmentStandard Published on 2013-08-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Alpha Antiviral compound antiviral genes Cell culture cell lines cellular Characteristics characterized consequence CoV CoVs cyclosporin A cytotoxicity develop disease electron microscopy expression found highlight Human humans identify IFN-α implicated implication in vitro induce Infected Infection infectious inhibit inhibited inhibitor innate immune response Interaction interferon Interferon-α membrane membranes MERS-CoV MERS-CoV infection MERS-CoV-infected patients Middle East nuclear translocation observation outbreak outcome phosphorylated Prevent progeny related Replication respiratory RNA synthesis SARS-CoV Stat1 titre Treatment Vero Cell Vesicle viral RNA synthesis was used were used zoonotic CoV [DOI] 10.1099/vir.0.052910-0 PMC 바로가기 [Article Type] Standard
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirusArticle Published on 2005-06-142022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] 2003 active against Antiviral antiviral activity antiviral agent Antiviral compounds antiviral drug antiviral potency assay automated be applied compounds coronavirus cytotoxicity demonstrated detect development Drug discovery EGFP expression evaluated Express facilitate fluorescent gastroenteritis Health High-throughput screening homogeneous inhibitor initial screening outbreak Protein risk SARS-CoV SARS-CoV infection severity specificity Spread therapeutic agent viral disease virus viruses [DOI] 10.1016/j.jviromet.2005.05.010 PMC 바로가기 [Article Type] Article