Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2Cardiovascular Medicine Published on 2021-02-232022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] ACE2 ACE2 gene analyzed angiotensin converting enzyme 2 association BNP Brain cardiac function cardiovascular disease cellular distribution Clinical outcome clinical outcomes Comorbidity COVID-19 COVID-19 patient Critical demonstrated dysfunction enzyme expression expression level facilitate failure heart heart failure hearts hypertension increased risk infective Inflammatory Injury mechanism Mortality myocarditis New observation Patient patients peptide performed plasma Potential Regulatory Replication Retrospective analysis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scRNA-seq Signaling significantly significantly higher significantly increased Single-cell RNA sequencing single-center susceptibility up-regulated upregulation virus entry virus infection virus replication with COVID-19 [DOI] 10.3389/fcvm.2021.628885 PMC 바로가기 [Article Type] Cardiovascular Medicine
Current Recommendations for Airway Management Techniques in COVID-19 Patients without Respiratory Failure Undergoing General Anaesthesia: A Nonsystematic Literature ReviewReview Papers Published on 2021-02-192022-10-28 Journal: Acta Medica Lituanica [Category] COVID-19, [키워드] acute respiratory syndrome aerosol generating procedure Aerosol generation airway airway management anaesthesia analysed Analysis Appropriate article available data Care Clinical practice Contamination coronavirus coronavirus disease COVID-19 COVID-19 patient current database difficult airway drugs equipment Evidence failure general anesthesia Google Scholar implication infected patient intubation lack literature management material pandemic Patient patients preoxygenation protocol reduce respiratory Respiratory failure review risk SARS-CoV-2 technique unique was performed [DOI] 10.15388/Amed.2021.28.1.9 PMC 바로가기 [Article Type] Review Papers
To Push or To Pull? In a Post-COVID World, Supporting and Incentivizing Antimicrobial Drug Development Must Become a Governmental Priority밀거나 당기려면? 코로나 이후 세상에서 항균 약물 개발을 지원하고 장려하는 것은 정부의 우선 순위가 되어야 합니다Perspective Published on 2021-02-192022-09-10 Journal: ACS Infectious Diseases [Category] MERS, SARS, 신약개발, [키워드] access Analysis antimicrobial antimicrobial resistance Antimicrobials appear catastrophic collapse consequence coordination COVID-19 pandemic Critical development Diseases drug Effect failure focus funding fungi global health global health policy Government greater Health health system health systems IMPROVE infectious agent Infectious diseases International international cooperation lack market failure moment MOST must one health pathogenic bacteria priority protocol push and pull incentives Research research and development responsible Stress Supporting sustained [DOI] 10.1021/acsinfecdis.0c00681 PMC 바로가기 [Article Type] Perspective
Acute Renal Failure in a Patient With Severe Acute Respiratory Syndrome Coronavirus 2Internal Medicine Published on 2021-02-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute kidney injury acute respiratory syndrome Affect AKI coronavirus coronavirus 2 COVID Critical care Critically ill dialysis failure Hemodialysis hypoxemic incidence Infection invasive mechanical male morbidity and mortality nasal Organ failure organ system outcomes Patient Pneumonia renal renal replacement therapy required respiratory Respiratory failure SARS-CoV-2 the patient viral pathogen worsening worsening respiratory status [DOI] 10.7759/cureus.13406 PMC 바로가기 [Article Type] Internal Medicine
Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial란디올롤(베타 봉쇄)을 사용한 패혈성 쇼크의 역전에 대한 연구: 무작위 시험을 위한 STRESS-L 연구 프로토콜Intensive Care Published on 2021-02-162022-09-10 Journal: BMJ Open [Category] Fulltext, MERS, 임상, [키워드] 1:1 24 hours adjusted adult intensive & critical care Analysis approved assessment authorisation Beta Beta blocker Beta blockers bpm cardiac function Clinical practice clinical trial clinical trials collaboration competent Consensus defined detect dissemination drug East esmolol Ethics ethics committee failure Final group heart rate improvement include intensive care intensive care unit International International standards landiolol mechanism Medicine Medicines and Healthcare products Regulatory Agency Microbiology minute modulation Mortality Open-label Patient primary endpoint protocol randomisation randomised Randomised trial receive reduce Registered Registration reported required Research Ethics Result Safe Sepsis Septic shock Standard statistics & research methods steering committee submission survival Tachycardia the mean therapy Treatment Trial Trial Steering Committee usual care [DOI] 10.1136/bmjopen-2020-043194 PMC 바로가기 [Article Type] Intensive Care
Prolonged Oxygen Therapy Post COVID-19 Infection: Factors Leading to the Risk of Poor OutcomeInfectious Disease Published on 2021-02-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95%CI absence acute respiratory syndrome Admission adverse outcomes age breathlessness CAD calculated Care caused CCU Characteristics co-morbid condition co-morbidities co-morbidity Coronary artery disease coronavirus Coronavirus disease 2019 COVID COVID-19 Critical care death determine diabetes discharge discharged duration of symptoms elderly epidemiological Factor failure feature Gender group Health high risk High-resolution CT hospital hospitalisation hospitalised patient HRCT increased risk Infection Isolation leading Logistic regression analysis maintain male material median age moderate Mortality multiple comorbidity need for oxygen Odds ratio outcome oxygen Oxygen requirement Oxygen therapy Patient patients patients of COVID-19 polymerase chain Poor Presence Prolonged Prospective required reverse transcription risk risk factor Risk factors RNA RT-PCR SARS-CoV-2 severe COVID-19 disease Severe COVID-19 Infection single-stranded study period test negative therapy Thorax two group was done β-coronavirus [DOI] 10.7759/cureus.13357 PMC 바로가기 [Article Type] Infectious Disease
Adverse Outcomes Associated With Corticosteroid Use in Critical COVID-19: A Retrospective Multicenter Cohort StudyMedicine Published on 2021-02-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission Adverse adverse outcomes alanine aminotransferase ARDS assessment caused contributed coronavirus disease correlation Corticosteroid corticosteroid treatment COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill patients Cytokine storm determine died enrolled failure Fatality rate gluocorticoid hospital Hospital stay Hospitalized immune incidence inflammatory reaction Laboratory Liver injury Logistic regression Mortality much higher multi-organ failure Neutrophil-to-lymphocyte ratio Neutrophils no difference outcome outcomes Patient patients patients treated performed pulmonary fibrosis reduce SARS-CoV-2 SARS-COV-2 infection steroid Surveillance treated treated patient Treatment Viral load virus clearance White blood cells Wuhan [DOI] 10.3389/fmed.2021.604263 PMC 바로가기 [Article Type] Medicine
A Machine Learning Prediction Model of Respiratory Failure Within 48 Hours of Patient Admission for COVID-19: Model Development and ValidationObservational Study Published on 2021-02-102022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, 임상, [키워드] 48 hour Accuracy Admission Admitted Patient age artificial intelligence Care characteristic clinical decision collected COVID-19 demographic characteristics Deterioration development died discharged disease Early warning score Emergency failure help highest hospital hour index Invasive mechanical ventilation laboratory data Logistic regression machine learning machine learning approach Metrics Model modeling morbidity and mortality objective oxygen pandemic Patient patients patients with COVID-19 predict prediction Predictive Predictive model predictor variable prognostic reduce resources respiratory Respiratory failure respiratory rate Result risk score serum lactate severe acute respiratory syndrome coronavirus 2 Support the patient validation variable with COVID-19 [DOI] 10.2196/24246 PMC 바로가기 [Article Type] Observational Study
Clinical significance of cellular immunity function and inflammatory factors assays in alveolar lavage fluid for severe COVID‐19 pneumoniaResearch Article Published on 2021-02-092022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] affecting alveolar alveolar lavage fluid assessment assigned C‐reactive protein CD3 CD4 CD8 Cell cell count cells cellular immunity change chronic clinical impact Clinical significance collected correlated COVID‐19 COVID‐19 death group disease severity failure flow cytometry hypersensitive ICU admission IL‐6 immunoturbidimetry independent risk factor Inflammatory factor inflammatory factors intensive care Lymphocyte subset Patient PCT Peripheral blood Physiology Pneumonia procalcitonin Prognosis serum severe patients severity significantly higher SOFA SOFA score statistically survival group [DOI] 10.1002/jmv.26827 PMC 바로가기 [Article Type] Research Article
“Tocilizumab-an option for patients with COVID-19 associated cytokine release syndrome: A single center experience”, a retrospective study-original articleExperimental Research Published on 2021-02-082022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] acute respiratory syndrome assessment criteria clinical conducted Control coronavirus Corticosteroids country COVID-19 cytokine release Cytokine storm syndrome diagnosed died discharge discharged disease drug Duration effective Effectiveness Endpoint enrolled experimental group failure global pandemic group Hospital stay ICU intravenously Intubated IQR median median age Memorial Methylprednisolone moderate Mortality outcomes Oxygen requirement Patient patients patients died patients with COVID-19 patients with diabete Pneumonia reduce reducing Result retrospective Sample SARS-CoV-2 setting sick single center steroid subcutaneously survival TCZ the primary endpoint therapy Tocilizumab Total Treatment Trial were given Wuhan, China [DOI] 10.1016/j.amsu.2021.02.011 PMC 바로가기 [Article Type] Experimental Research