Genetic Characterization of the Belgian Nephropathogenic Infectious Bronchitis Virus (NIBV) Reference Strain B1648Communication Published on 2015-08-072022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accessory protein Amino acid Analysis B1648 Belgium characterization chicken circulating Complete complex determinant Europe Evolution Factor full-length genome Genetic genomes Genotype Gray highest IBV identify indicated Infectious Bronchitis Virus Intensive M protein Massachusett nephropathogenic NGS nonstructural protein North Open reading frame ORF ORFs Phylogenetic analysis predicted reference reported sequence sequence homology Sequencing Spike protein strain Strains transcriptase vaccination variant virulent was determined [DOI] 10.3390/v7082827 PMC 바로가기 [Article Type] Communication
The Nucleocapsid Protein of Human Coronavirus NL63Research Article Published on 2015-02-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis binding C-terminal domain Cell cell cycle progression cellular processes Characteristics Coronaviral coronavirus described disease expressing feature Genetic genomes HCoV-229E HCoV-NL63 homologous Human human coronavirus human coronavirus 229E infected cells involved N-terminal domain NL63 nucleic acid nucleocapsid protein nucleus oligomerization other coronaviruses pathogen Protein respiratory tract responsible reveal SARS-CoV severity subcellular localization the N protein transfected cells unique viral replication [DOI] 10.1371/journal.pone.0117833 PMC 바로가기 [Article Type] Research Article
Whole-Genome Scans Provide Evidence of Adaptive Evolution in Malawian Plasmodium falciparum Isolates전체 유전체 스캔이 말라위 Plasmodium falciparum 분리주에서 적응 진화의 증거를 제공합니다.Article Published on 2014-12-152024-08-13 Journal: Nanoscale [Category] 말라리아, [키워드] Genetic epidemiology genomes Malawi Plasmodium falciparum [DOI] 10.1093/infdis/jiu349 PMC 바로가기
Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes폐렴구균 모자이크 유전자 내 베타-락탐 내성과 관련된 단일 뉴클레오티드 다형성의 포괄적인 식별Research Article Published on 2014-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] alterations Amino acid analysed antibiotic Antibiotic resistance Antibiotic treatment Antibiotics approach arise association Bacteria Beta-lactam beta-lactam antibiotics block blocks carried cause change children clinical setting collected Comprehensive description determinant determinants Diseases distribution DNA fragment explain Frequency Genetic genetic association genetic determinant genetic determinants Genome Genome sequencing Genome-wide association study genomes Haplotype identification identify INDEL indels independent dataset independent datasets introduced isolate isolates large sample leads lineages loci mechanism Meningitis morbidity morbidity and mortality more difficult mosaic Mutation nasopharyngeal non-susceptibility nucleotide organism performed pneumococcal Pneumonia pneumoniae populations predict Previous studies previous study raise Recombination reported resistance responsible sensitivity sequence single nucleotide Single nucleotide polymorphism single nucleotide polymorphisms SNPs Spread strain Strains Streptococcus pneumoniae susceptible Traditional Treatment understanding USA variant variants while [DOI] 10.1371/journal.pgen.1004547 PMC 바로가기 [Article Type] Research Article
Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex알파인 아이벡스의 주요 조직 적합성 복합체에서 국내 염소 생성 변이로부터의 이입Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive allele alleles Alpine ibex balancing selection breed carried chromosomal region Clustering coding coding regions Defense Evidence functional gene genetic diversity Genetic polymorphism genetic variability Genetic variation genomes goat Haplotype haplotypes heterozygosity histocompatibility histocompatibility complex homozygous Ibex identify immune system individual introgression investigated involved loci locus Major major histocompatibility complex mechanism MHC non-coding region pathogen Pathogens polymorphism populations provide Research restored sequence sequenced Sequencing signature SNP SNP allele SNP alleles species Support susceptible thought two allele Two alleles Variation [DOI] 10.1371/journal.pgen.1004438 PMC 바로가기 [Article Type] Research Article
Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article
Genomic Profiling of Collaborative Cross Founder Mice Infected with Respiratory Viruses Reveals Novel Transcripts and Infection-Related Strain-Specific Gene and Isoform ExpressionMouse Genetic Resources Published on 2014-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] acute respiratory syndrome aligned base pair collaborative cross conserved coronavirus differential expression eight elements expression gene transcription Genetic variation Genome genomes genomic host response identify Infection influenza A virus instance isoform isoform differential expression junctions knowledge lung mice mouse transcriptome annotation Mutation novel Profiling proportion recorded respiratory respiratory virus resulting RNA sample RNA-Seq sequence sequenced strain Strains transcribed transcript transcriptional transcriptional profile transcriptional response Transcriptome transcripts unlikely Variation viral infection [DOI] 10.1534/g3.114.011759 PMC 바로가기 [Article Type] Mouse Genetic Resources
Novel Betacoronavirus in Dromedaries of the Middle East, 2013Research Published on 2014-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis association Betacoronavirus Camel camel coronavirus cleavage site Complete conducted coronavirus DcCoV DcCoVUAE-HKU23 dromedaries Dromedary dromedary camel coronavirus UAE-HKU23 dromedary coronavirus Dubai Fecal sample G+C Genome genomes humans infect Lineage membrane protein MERS-CoV Middle East Middle East respiratory syndrome Coronavirus novel novel Betacoronavirus nucleocapsid protein phylogenetically serum sample Surveillance tested United Arab Emirates virus virus transmission viruses zoonoses [DOI] 10.3201/eid2004.131769 PMC 바로가기 [Article Type] Research
Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases온대 파지는 이완된 상동 재조합에 의해 결함 있는 프로파지로부터 DNA를 획득한다: Rad52-유사 재조합효소의 역할Research Article Published on 2014-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addressed Bacteria Bacterial bacterial virus bacterial viruses bacteriophage bacteriophages Bioinformatics analysis biosphere catalyzed comparison complementary contribute defective prophages dependent on Divergence DNA dormant dormant state E. coli Efficiency element Escherichia coli Evidence evidence of Evolution exchange functions gene exchange gene exchanges gene transfer Genetic genetic determinant genetic determinants genetic diversity genetic exchanges Genome genomes genomic Homologous recombination homologous recombination enzymes horizontal gene Horizontal gene transfer Hypothesis in vivo Infection lambdoid phage lambdoid phages majority mechanism molecular mechanisms mosaicism no evidence of phage phage encoded recombinase phage encoded recombinases phage gene phage genome phage λ phages phenotype promote prophage prophages Rad52 RecA REcombinase recombinases Recombination replicate role sequence sequence homology sequences subject Temperate bacteriophage Temperate bacteriophages temperate phage temperate phages transfer virulence virulent virulent phages viruses vivo assays [DOI] 10.1371/journal.pgen.1004181 PMC 바로가기 [Article Type] Research Article
A Leaderless Genome Identified during Persistent Bovine Coronavirus Infection Is Associated with Attenuation of Gene ExpressionResearch Article Published on 2013-12-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Analysis attenuation Bovine coronavirus Cell culture contribute determined different downstream Efficiency example expression found Frame Genome genomes genomic genomic RNA Identified Infected Infection mutant viruses ORF persistence persistent Postinfection replicative retained RNA selected sequence sgmRNA subgenomic mRNA Transcription translation viral infection was impaired [DOI] 10.1371/journal.pone.0082176 PMC 바로가기 [Article Type] Research Article