Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and PathogenicitySARS-CoV-2 스파이크 돌연변이 D614G가 전염성과 병원성에 미치는 영향 평가Article Published on 2021-01-072022-09-11 Journal: Cell [Category] MERS, SARS, 변종, [키워드] age Analysis approach association Clinical severity Cluster COVID-19 COVID-19 mortality D614G dataset dispersal Effect Epidemiology Evaluating Evolution founder effect Frequency genetic analysis greater growth Hypothesis increases in Increasing indicate Mortality mutation D614G Patient patient age patients phylogenetic cluster Population Population genetic analysis Positive selection random SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 sequences selective Severity of infection Significant significant differences significantly spike Spike protein Spread the SARS-CoV-2 United Kingdom variant variants Viral Viral load whole genome younger patient younger patients [DOI] 10.1016/j.cell.2020.11.020 PMC 바로가기 [Article Type] Article
The Epidemiology and Predictors of Outcomes Among Confirmed COVID-19 Cases in a Large Community Healthcare System in South FloridaOriginal Paper Published on 2021-01-072022-10-29 Journal: Journal of community health [Category] COVID-19, MERS, SARS, [키워드] age being breath Characteristics Community Comorbidity conducted Confirmed confirmed COVID-19 case COVID-19 COVID-19 patient death Dementia determine disease Epidemiology greater Healthcare system Hispanic ethnicity Hospitalization hypertension ICU admission increased risk increased the risk Increasing individual Infectious disease less likelihood Memorial multivariate logistic regression Neurological disorder novel coronavirus disease outcome outcomes oxygen oxygen saturation Patient predictor presenting public health Racial/ethnic disparities readmission reduce respiratory rate Result Retrospective analysis risk SARS-CoV-2 SARS-COV-2 infection saturated Significant South study outcomes supplementary material System temperature Vital were used [DOI] 10.1007/s10900-020-00957-y PMC 바로가기 [Article Type] Original Paper
Epidemiological, Clinical, and Laboratory Predictors of In-Hospital Mortality Among COVID-19 Patients Admitted in a Tertiary COVID Dedicated Hospital, Northern India: A Retrospective Observational StudyObservational Study Published on 2021-01-012022-10-05 Journal: Journal of primary care & community health [Category] 임상, [키워드] Admission age blood urea Care Characteristics clinical collected COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients determine epidemiological Epidemiology health system hemoglobin hospital Hospital admission Hospital mortality in-hospital mortality Increasing independent risk factor investigated Laboratory leukocyte material Mortality occurred oxygen saturation predictor profile Protective Record respiratory rate Section temperature Tertiary urea [DOI] 10.1177/21501327211041486 PMC 바로가기 [Article Type] Observational Study
The Artificial-Liver Blood-Purification System Can Effectively Improve Hypercytokinemia for COVID-19인공 간 혈액 정화 시스템은 COVID-19에 대한 과세포 운동 혈증을 효과적으로 개선할 수 있습니다Clinical Trial Published on 2020-12-232022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 치료기술, [키워드] ALS ARDS artificial-liver blood-purification system Can Clinical treatment clinical treatment of COVID-19 contagious coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients cytokine Cytokine storm Cytokines death diagnose effective Evidence expected focus hypercytokinemia IMPROVE Increasing Infection Inflammatory mediators international public health IP-10 mediators New outbreak outcome pandemic pre- and post-ALS progression resulting shown Spread suppress System the cytokine storm the disease Treatment treatment strategy Wuhan [DOI] 10.3389/fimmu.2020.586073 PMC 바로가기 [Article Type] Clinical Trial
Fever in the ICU: A Predictor of Mortality in Mechanically Ventilated COVID-19 PatientsOriginal Research Published on 2020-12-152022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, SARS, [키워드] age Analysis conducted coronavirus COVID-19 COVID-19 case COVID-19 patient COVID-19 patients Critical Critically ill determine died discharged Fever Final Follow-up greater higher risk hospital Hospital admission hyperthermia ICU ICU patient identify IMPROVE Increasing initial male Male sex management material Mortality Older outcome outcomes oxygen saturation Patient Predictive predictor presenting resource retrospective cohort study risk stratification survived survivor Symptom temperature Ventilated were excluded while [DOI] 10.1177/0885066620979622 PMC 바로가기 [Article Type] Original Research
Optimizing COVID-19 surveillance in long-term care facilities: a modelling study장기 요양 시설에서 COVID-19 감시 최적화: 모델링 연구Research Article Published on 2020-12-082022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis Asymptomatic baseline Care cascade cascades Chain Reaction clinical symptom Computational modelling Contact Contact network coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms cumulative detect diagnostic diagnostic sensitivity distribution effective Efficacy epidemiological epidemiological surveillance evaluated expressing facilitate group test IMPROVE Increasing indication inefficient Infection infections Infectious disease surveillance information inter-individual Interaction Intervention limitations Long-term care Mathematical modelling Nasopharyngeal swab nasopharyngeal swabs nosocomial Nosocomial transmission outbreak Outbreaks Patient polymerase chain polymerase chain reaction pooling pre-symptomatic Probability proportion protocol public health random Randomly resource resources respiratory Result reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR tests SARS-CoV-2 SARS-COV-2 infection selected sensitivity severe acute respiratory syndrome Coronavirus silent supplementary material Surveillance Swab Symptom symptom onset Symptoms Testing transcriptase Transmission Transmission dynamics [DOI] 10.1186/s12916-020-01866-6 PMC 바로가기 [Article Type] Research Article
Increasing influenza vaccination coverage in healthcare workers: a review on campaign strategies and their effectReview Published on 2020-12-072022-10-29 Journal: Infection [Category] COVID-19, [키워드] analyzed clinics conducted Coverage COVID-19 pandemic effective healthcare healthcare personnel healthcare worker immunization immunization programs implementation increase in Increasing Influenza Influenza virus Intervention lesson mandatory measure reached Result resulting SARS-CoV-2 vaccination Seasonal influenza vaccination Vaccine uptake rate [DOI] 10.1007/s15010-020-01555-9 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain OrganoidsShort Article Published on 2020-12-032022-10-31 Journal: Cell Stem Cell [Category] COVID-19, SARS, [키워드] ACE2-expressing cell acute respiratory syndrome Apolipoprotein barrier blood-CSF-barrier Brain brain organoid caused Cell cell types Cerebral organoids cerebrospinal fluid choroid choroid plexus organoids Complication coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine epithelial epithelial cell expressed expressing expression Glia Human immune cells Increasing infect infected cell Infection infection with SARS-CoV-2 Lipoproteins Live virus Neurological symptom Neuron neurons Organoid Pathogens patients Plexus Prevent pseudovirus receptor ACE2 respiratory symptom SARS-CoV-2 SARS-CoV-2 entry factor SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV-2 spike significantly susceptible viral tropism virus [DOI] 10.1016/j.stem.2020.10.001 PMC 바로가기 [Article Type] Short Article
Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13Immunology Published on 2020-12-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activated neutrophil Activation acute ischemic stroke ADAMTS13 addition aggregation AIS Blood Cell Characteristics complex contribute COVID-19 endothelial endothelial damage events Evidence Factor immunothrombosis Increasing indicate induce Inflammation insight Interaction metalloproteinase Mortality motifs NET NETs Neutrophil extracellular trap Neutrophil extracellular traps occur predict reduction regulated released secretion stroke targeting therapeutic strategy thrombosis thrombotic thrombotic microangiopathy vasculature Venous thrombosis von Willebrand factor vWF [DOI] 10.3389/fimmu.2020.610696 PMC 바로가기 [Article Type] Immunology
Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York CityObservational Study Published on 2020-12-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 95% CI acute renal failure adjusted odds ratio Admission age Analysis assessment association body mass index chi-square tests coronavirus disease correlated discharge home Encephalopathy Exploratory analysis failure Gender Health hospital hyponatremia identify Impact In-hospital death in-hospital mortality increased risk Increasing independent interleukin-6 Invasive mechanical ventilation Kruskal-Wallis laboratory abnormalities laboratory-confirmed measurement mechanical ventilation Mild moderate morbidity and mortality multicenter multivariable logistic regression New York City nonosmotic normonatremia Observational cohort study occur occurred outcome past medical history Patient patients patients with pneumonia predictors Prevalence Primary outcome Probability renal required secondary severity sodium sodium level worsening [DOI] 10.1097/CCM.0000000000004605 PMC 바로가기 [Article Type] Observational Study