interfere
[용어속성] Action
On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2
Article
[키워드] acute respiratory syndrome
Antiviral
base
bioinformatic analysis
caused
cells
Characteristics
Chloroquine
Cluster
Coronavirus disease-19
Coronavirus-2
COVID-19
drug
Effect
Effects
Endosomes
Epidemic
haloperidol
Hydroxychloroquine
Imatinib
include
inhibit SARS-CoV-2
inhibiting
inhibitor
interfere
Lysosomes
lysosomotropic agents
non-specific
organelle
other coronavirus
Penetrating
performed
pharmacological
physicochemical characteristics
Replication
replication of SARS-CoV-2
SARS-CoV-2
SARS-CoV-2 replication
suppress
targets
tyrosine
Vero E6 cell
viral infection
viral replication
Virtual screening
[DOI] 10.1038/s41419-020-02842-x PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41419-020-02842-x PMC 바로가기 [Article Type] Article
Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-Dimensionally Printed Surgical Mask Materials
3차원으로 인쇄된 외과용 마스크 재료에서 중증 급성 호흡기 코로나바이러스 2(SARS-CoV-2) 및 다양한 RNA 및 DNA 바이러스의 비활성화
Original Article
[키워드] Ammonium
approach
approaches
bleach
clinically
compounds
coronavirus disease
Coronavirus disease 2019
COVID-19
Critical
decontamination
DNA
dry heat
effective
equipment
exposure to
health administration
healthcare
heat
HIV-1
Human immunodeficiency virus
hydrogen
hydrogen peroxide
inactivated
inactivation
interfere
isopropanol
less
Mask
Masks
material
pandemic
pathogenic viruses
Pathogens
Personal protective equipment
PPE
Prevent
Protective
reduced
respiratory
Respiratory Coronavirus
RNA
SARS-CoV-2
significantly
surgical
tested
viral pathogen
viral pathogens
viral titer
viral titers
virus
[DOI] 10.1017/ice.2020.417 PMC 바로가기 [Article Type] Original Article
[DOI] 10.1017/ice.2020.417 PMC 바로가기 [Article Type] Original Article
Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review
Cardiovascular Medicine
[키워드] 2019 novel coronavirus
ACE2
ACE2 mRNA
acute respiratory syndrome
Angiotensin 1-7
bind
cardiovascular damage
cardiovascular diseases
cardiovascular system
caused
cells
clinical development
clinical manifestation
coronavirus
COVID-19
develop
disease
downregulation
drug
epithelial cells
expressed
expression
Heart damage
host cell surface
hydroxychloroquine/chloroquine
interfere
Local
losartan
lung
lung alveolar
mechanism
modulate
mRNA expression
narrative
pandemic
Patient
patients with COVID-19
pulmonary damage
RAS
RAS inhibitor
RAS inhibitors
reduced
renin-angiotensin system
respiratory symptoms
responsible
review
SARS-CoV-2
System
therapy
Transmission
umifenovir
virulence
virus
[DOI] 10.3389/fcvm.2020.00143 PMC 바로가기 [Article Type] Cardiovascular Medicine
[DOI] 10.3389/fcvm.2020.00143 PMC 바로가기 [Article Type] Cardiovascular Medicine
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Report
[키워드] Analysis
Antiviral
antiviral immunity
bacterial superinfections
Blood
cause
characterized
Cohort
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 patient
Critical
critical COVID-19 patient
deficiency
dendritic cell
Disease progression
disease severity
driven by
driving
elicit
engage
ENhance
epithelial
exacerbated
expressed
expression
functions
hallmark
host immune responses
IFN
IFN signaling
IFN-stimulated gene
IFN-α
IFN-β
IFN-λ
IFNs
immune
Immune cell
immunopathology
Impaired
increase
Inflammatory response
influenza infection
inhibiting
interfere
interferon
interleukin-6
ISGs
Local
lung
lung epithelium
Major
mice
morbidity
mucosal surface
Necrosis
nuclear
p53
parameter
patients
performed
Peripheral blood
phenotype
proinflammatory
proliferation
respiratory viral infections
response
responses
Science
secreted
severe COVID-19
severe COVID-19 patient
severity
Signaling
susceptibility
therapeutic
therapeutic approaches
thought
Transcription
transcriptional
Trigger
turn
Type
type I
Type I IFN
type I interferon
Type III IFN
viral infections
Viral load
viral respiratory disease
viral respiratory infections
Viral RNA
[DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report
Type III interferons disrupt the lung epithelial barrier upon viral recognition
Report
[키워드] aberrant immune response
acute respiratory syndrome
airway
Antiviral
antiviral immunity
bacterial superinfections
cause
characterized
Clinical practice
contribute
coronavirus
coronavirus disease
COVID-19
COVID-19 patient
Critical
critical COVID-19 patient
dendritic cell
disrupt
driving
elicit
Endemic
engage
ENhance
epithelial
Evidence
expressed
expression
functions
IFN
IFN signaling
IFN-stimulated gene
IFN-α
IFN-β
IFN-λ
IFNs
Immune cell
immunopathology
increase
indicate
induce
Infection
influenza infection
Influenza virus
inhibiting
interfere
ISGs
Local
Lower respiratory tract
lung
lung epithelial
lung epithelium
Major
mice
morbidity
Mortality
Mounting
mucosal surface
Necrosis
p53
parameter
Pathogenesis
pathophysiological
Patient
Peripheral blood
produced
proinflammatory
proliferation
respiratory viral infections
response
responses
RNA viruses
SARS-CoV-2
Science
secreted
Severe case
severity
susceptibility
therapeutic
thought
Transcription
Trigger
turn
Type
type I
Type I IFN
Type III IFN
type III interferon
viral burden
viral infections
viral respiratory disease
viral respiratory infections
Viral RNA
viruses
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report
Food and COVID-19: Preventive/Co-therapeutic Strategies Explored by Current Clinical Trials and in Silico Studies
Review
[키워드] acting
acute respiratory syndrome
carrier
clinical
clinical trial
component
components
Compound
compounds
coronavirus
coronavirus disease
COVID-19
COVID-19 pandemic
current
enhancer
etiological agent
food
functional
Health
Host
immune system
in silico
in silico study
in vitro
in vivo
infective
Interaction
interfere
knowledge
micronutrient Clinical trial
micronutrients
pandemic
promote
protein interaction
Research
SARS-CoV-2
Strategy
target
the SARS-CoV-2
therapeutic molecules
Therapies
virus
[DOI] 10.3390/foods9081036 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/foods9081036 PMC 바로가기 [Article Type] Review
Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion
Article
[키워드] alphacoronavirus
alphacoronavirus nsp1
Analysis
Basis
Betacoronavirus
Biological
biological function
Cell
cell cycle
cell cycle genes
Cellular immune response
characterized
composed
conserved
creating
crystal structure
experiment
full-length
Host
host cell
host protein
host proteins
IFN
IFN-I
immune
Infectious disease
inhibit
inhibiting
inhibitory effect
interfere
interferon
mammalian cell
mechanism
PEDV
Phosphorylation
proliferation
Protein
regulate
regulated
Regulatory
Renilla luciferase
RNA sequence
RNA sequencing
selected
Seven
significantly
structure-function
structures
subtype
TGEV
treated
Viral virulence
virus
western blotting
β-CoV
β-CoVs
[DOI] 10.3390/v12080812 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/v12080812 PMC 바로가기 [Article Type] Article
Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS
Case Report
[키워드] acute respiratory distress
acute respiratory distress syndrome (ARDS)
Antiviral
approach
ARDS
BMI
C-reactive protein
calibrated
Case report
cells
clinical condition
Coagulation
Combination
Combined
COVID-19
COVID-19 patient
Cytokines
decrease
dropped
Dyspnea
effort
Endothelium
Fever
hypoxia
IL-6
IL-6 receptor
immune-mediated inflammation
Immunotherapy
IMV
Inflammation
Inflammatory
interfere
interleukin-6
Intubated
Invasive mechanical ventilation
Laboratory
limit
male
management
monoclonal antibody
Neutrophil-to-lymphocyte ratio
NIV
NLR
non-invasive ventilation
outcomes
Oxygenation
P/F
P/F ratio
PaO
Pathogenesis
Patient
Pneumonia
prone positioning
Rapid
reducing
reported
response
suggested
syndrome
TCZ
therapy
Tocilizumab
treated
Treatment
ventilatory strategy
with COVID-19
worsening
[DOI] 10.3390/medicina56080377 PMC 바로가기 [Article Type] Case Report
[DOI] 10.3390/medicina56080377 PMC 바로가기 [Article Type] Case Report
Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis
Microbiology
[키워드] 3CLpro
Against
anti-SARS-CoV-2 therapeutics
catalytic dyad
China
complex
coronavirus
COVID-19
disease
docking study
drug
Drug repurposing
functional
in silico
in silico analysis
Infection
interfere
macromolecule
main-protease (3CLpro)
novel coronavirus SARS-CoV-2
NTP
outcome
oxolinic acid
polymerase
positive
predicted
quinoline based-drugs
RdRP
RNA-dependent RNA-polymerase
SARS-CoV-2
SARS-CoV-2 RdRp
seeking
specific treatment
spike-ACE2 complex
Spread
spread to
suggested
the WHO
treat
Treatment
viral entry
[DOI] 10.3389/fmicb.2020.01796 PMC 바로가기 [Article Type] Microbiology
[DOI] 10.3389/fmicb.2020.01796 PMC 바로가기 [Article Type] Microbiology