intervention group – Page 24 – Communicable Diseases Research

Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial

당뇨병과 같은 동반 질환이 없는 새로 진단된 COVID-19 감염 환자를 치료하기 위한 Hydroxychloroquine, Oseltamivir 및 Azithromycin의 코로나바이러스 치료(PROTECT) 평가를 위한 파키스탄 무작위 및 관찰 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-08-082022-08-13
Journal: Trials [Category] MERS, 임상,

Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trial

Letter

Published on 2020-07-292022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] 1:1 acute respiratory syndrome Adults adverse event antiretroviral Antiviral Arm Barcelona blinded Blood Breastfeeding Chloroquine condition confirmed case confirmed COVID-19 case Contact Control control group Controlled clinical trial coronavirus coronavirus disease Corticosteroid COVID-19 declining defined develop disease dissemination double-blind double-blinded Efficacy element eligibility Epidemic equipment evaluate Follow-up group healthcare worker Healthcare workers high risk hospital Hydroxychloroquine hydroxychloroquine treatment identify incidence Infection Intervention intervention group investigator marker multicentre National number Nurse objective Occurrence Older outcome participant Participants PCR physical Placebo placebo tablet polymerase chain positive PCR PPE pre-exposure predict predictor Pregnancy primary endpoint Prophylaxis protocol random randomisation randomised randomised controlled trial Randomized Randomized controlled trial Rapid diagnostic test RDT reached receive recruited reducing Registered Repository Research risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Secondary endpoints Seroconversion serological serology serum sample Spain Spanish Standard of care status Study protocol Symptom Tablet the placebo group the SARS-CoV-2 Treatment Trial website with COVID-19
[DOI] 10.1186/s13063-020-04621-7 PMC 바로가기 [Article Type] Letter

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol

Letter

Published on 2020-06-262022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 24 hour Administered airway allocation concealment Alpha ambient analysed aneurysms Anticoagulant treatment anticoagulation antiplatelet Arm arterial assigned Atrial fibrillation bleeding bleeding event block size Blood BMI Body Breastfeeding breath calculated Cancer clinical clinically Coagulopathy Concomitant conjunctival Continuous contributed Control control group Controlled trial corpus COVID-19 COVID19 criteria Critical D-dimer D-dimer level Day death defined detect diagnostic discharged disease severity dissemination dosage dose effective Efficacy and safety element enoxaparin Epistaxis EudraCT event events expected fibrinogen level gingival bleeding group Haemoglobin haemoptysis health-care hematemesis hematoma hemodynamic heparin High dose high risk history hospital discharge Hospital stay hospitalized patient hypersensitivity Hypothesis IL-6 Impaired impairing improvement IMV In-hospital indication initiated Inpatient INR internal Intervention intervention group Intra-articular intramuscular invasive Invasive mechanical ventilation involved Italian Italy laboratory parameter LMWH low dose low-molecular weight heparin macroscopic Major major bleeding management Mechanical mechanical ventilation medical intervention Medicine Modena NIV Non-invasive number objective occur Occurrence open label ophthalmic oral anticoagulant outcome oxygen paO2/fiO2 parallel group participant pathology Patient performed Pharyngeal swab plasma Platelet Pneumonia positive pregnancy test Presence pressure Primary outcome prophylactic dose prosthetic protocol random randomisation randomised randomised controlled randomised controlled trial randomization Rate receiving recorded recruited Rectal Bleeding reduce reduction in Registered renal function reported required respiratory risk risk of death Sample size SARS-CoV-2 secondary secure Severe COVID-19 pneumonia severe disease significantly Spontaneous standard oxygen therapy Stata status stratified stroke study drug Study protocol subcutaneously surgical susceptible symptomatic syndrome therapeutic dose therapy thrombocytopenia time transfusion Treatment unfractionated heparin unit Vascular venipuncture Venous Thromboembolism web-based system website weight Withdrawal worsening
[DOI] 10.1186/s13063-020-04475-z PMC 바로가기 [Article Type] Letter

Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-06-192022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 24 hours acute respiratory distress administration Admission age age and sex allergy ARDS Arm blinded Blood oxygen saturation can be used checked clinical coded Combination combination regimen Computed tomography conducted Contact Control control arm Corticosteroid Corticosteroids COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokine storm develop Dexamethasone dissemination dosage dose drug early administration education Efficacy element eligible excessive inflammatory response experimental group Frequency generate group help hepatitis B HIV positive hospital Hospitalization hospitalized patient Hypothesis Immunoglobulin IMPROVE increase in Inflammation information Interferon-beta Intervention intervention group Intravenous immunoglobulin intubation investigator Iran laboratory technician less lung lung damage management mortality rate MOST number Nurses objective outcome Parallel Arm participant Patient patients Patients management percentage positive RT-PCR Pregnancy protocol random random number generator randomised randomised controlled trial randomization Randomized controlled trial Randomly RCT receive reduce Registration reported researcher respiratory rate Sample size severe COVID-19 Side effects Standard standard treatment statistical statistician study drug study group Study protocol subject supportive care syndrome the cytokine storm the WHO treat Treatment Trial website WHO guideline
[DOI] 10.1186/s13063-020-04499-5 PMC 바로가기 [Article Type] Letter

Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-102022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 Administered age antibiotic antiviral efficacy Asthma Azithromycin Beta blocker blinded block calcium cardiovascular change changed chronic clinical combination therapy Control control group coordinator COPD COVID-19 COVID-19 test Day days alive death derivative Diagnosis Direct Current discharged disorder dissemination double-blind study ECG element ergot alkaloid expected Final FiO2 generate Glucose glucose-6-phosphate dehydrogenase deficiency guide hearing loss hematological hospital hospitalisation Hospitalization hospitals Hydroxychloroquine hypersensitivity impede Inclusion Informed consent intensive care Interstitial lung disease Intervention intervention group invasive ventilation investigated investigator Liver disease lung maculopathy medication mental illness modulation myasthenia gravis negative pregnancy test network Neurogenic neurological number objective offered outcome parallel group participant Patient patients with COVID-19 Placebo pregnant Primary outcome problem protocol psoriasis pulmonary QTc QTc interval randomisation randomised randomised controlled trial receive recruited recruitment reduce Registered reported respiratory infections retinopathy risk Sample size sequence significantly Sponsor Standard standard care standard treatment status Stratification Study protocol the patient therapy treated Treatment Trial Visual field website women
[DOI] 10.1186/s13063-020-04409-9 PMC 바로가기 [Article Type] Letter

A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): A structured summary of a randomized controlled trial study protocol

Letter

Published on 2020-06-082022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] 1:1 24 hour 28-day mortality activated acute respiratory distress syndrome Administered Admission adverse effect age albumin allergic allocation concealment Anticoagulant apheresis approval approved assessment Basel block size C-reactive protein category changes in city Coagulopathy Control COVID-19 COVID-19 disease criteria Cytokine release syndrome D-dimer defined disease dissemination drug eight element Enrollment evaluate evaluated ferritin fibrinogen first dose FIVE food function group ICU ICU admission ill patient Improving Inc. Inflammatory ingredient intensive care intensive care unit International Intervention intervention group intubation IRB ISRCTN KDIGO King Kingdom Laboratory lack lactate dehydrogenase life threatening life-threatening Life-threatening COVID-19 marker measure Mild Ministry of Health Multicenter trial Multisystem organ failure National negative RT-PCR normalized number objective occur on mechanical ventilation Open-label outcome Palliative care participant Participants Patient patients performed pilot study plasma primary site Prothrombin time protocol Qiagen randomization randomize Randomized Randomized controlled trial randomized trial Real-time PCR receive receiving recommendations recruit reduce replaced Roche RT-PCR RT-PCR kit Safety Sample size SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Saudi Arabia secondary serum Seven sodium SOFA status Stratification Study protocol supportive care Switzerland System Therapeutic plasma exchange therapy TPE treatment for COVID-19 tumor necrosis factor-alpha USA Volume website
[DOI] 10.1186/s13063-020-04454-4 PMC 바로가기 [Article Type] Letter

Two Randomized Controlled Trials of Bacillus Calmette-Guérin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trials

Letter

Published on 2020-06-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 ambulance service assistant Bacillus BCG BCG vaccination BCG-vaccine blinded Care Community Controlled COVID-19 COVID-19 infection COVID-19 pandemic cumulative Denmark dissemination elderly element facilitate HCW HCWs Health care Health care worker Health-care workers hospital Hospital admission hospitals incidence Intervention intervention group investigators Medicine NaCl Netherlands number objective outcome outcome assessor parallel group participant Patient physician Placebo placebo group placebo-controlled protocol randomised randomised controlled trial Randomized randomized trial recruitment reduce Registered registry Research Sample size status stratified Study protocol the placebo group Trial vaccination Vaccine website
[DOI] 10.1186/s13063-020-04389-w PMC 바로가기 [Article Type] Letter

Effect of hydroxychloroquine on prevention of COVID-19 virus infection among healthcare professionals: a structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 allocation analyzed anticipated approval blinded clinical symptom clinical trial Complete conducted Confirmed Contact Control control group COVID COVID-19 COVID-19 virus criteria dissemination dosage dose double-blind drug Dyspnea Effect element enzyme deficiency Epidemic Fever G6PD healthcare Healthcare professional healthcare professionals history hospital Hydroxychloroquine hypersensitivity independent Infection intervention group Iran Medical Sciences myalgia nausea number objective outcome participant Patient PCR pharmaceutical Pharmacy Placebo placebo-controlled trial polymerase chain reaction Prevent prevention prevention of COVID-19 Primary outcome protocol random randomised randomised controlled trial randomization randomization list Randomized recruitment researcher Sample size statistical status Study protocol Tablet Tehran treatment allocation treatment group Trial Trial registration underlying disease university virus virus infection website
[DOI] 10.1186/s13063-020-04439-3 PMC 바로가기 [Article Type] Letter

Effectiveness of Interferon Beta 1a, compared to Interferon Beta 1b and the usual therapeutic regimen to treat adults with moderate to severe COVID-19: structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 95% confidence interval Adjusted analysis Administered Admission age alcohol allocation concealment ALT/AST Analysis Arm arrhythmia assigned Beta block-randomization Blood calculated Care center clinical Clinical improvement clinical trial conducted confirmed case control group cough COVID-19 COVID-19 confirmed patient COVID-19 in patient COVID-2019 Cox proportional-hazards model death discharge disease dissemination drug Duration education Effectiveness element eligibility enrolled excluded exclusion criteria fatigue follow-up time hazard headache Health hospital hospital discharge Hospitalization Hydroxychloroquine + Lopinavir/Ritonavir improvement include Interaction Interferon beta-1a Interferon-β 1a Interferon-β 1b intervals intervention group investigator Kaletra Kaplan–Meier laboratory result lactating women Last limit log-rank test Loghman Hakim Hospital Lopinavir Lopinavir/ritonavir masking mechanical ventilation Medical Science Medical Sciences moderate Mortality myalgia nasal NCT04343768 number objective open label Open-label Other outcome oxygen saturation package parallel group participant Patient performed positive pregnant Primary outcome primary outcome measure problem professional protocol pulse-oximetry R software R version 3.6.1 randomization randomization sequence Randomized Randomized controlled trial Randomly reached receive Recigen recruitment refusal regimen Registered Research respiratory rate RT-PCR test Sample SARS-CoV-2 sealed secondary secondary outcome seven-category ordinal scale single center single dose SpO2 sputum production standard care status Study protocol Symptom temperature tested the patient therapeutic three groups time treat treated treatment groups Trial university version 3.6.1 website World Health Organization Ziferon
[DOI] 10.1186/s13063-020-04382-3 PMC 바로가기 [Article Type] Letter

An online solution focused brief therapy for adolescent anxiety during the novel coronavirus disease (COVID-19) pandemic: a structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-05-132022-10-29
Journal: Trials [Category] Coronavirus, MERS, SARS,

[키워드] Adolescent adolescents Anxiety anxiety symptom assigned Beijing Chinese Clinical outcome collected Controlled trial Coping strategy counseling COVID-19 COVID-19 outbreak COVID-19 pandemic criteria Depression Diagnosis disorder distress Effectiveness Enrollment exclusion criteria faculty GAD Generalized ideation inclusion criteria intervention group Juan medication mental health normal novel coronavirus disease objective open label participant presenting protocol Psychiatric Psychology randomised controlled trial Randomized Randomized controlled trial Randomly receive receiving Reporting solution Solution focused brief therapy Study protocol Taking therapy university Unwilling
[DOI] 10.1186/s13063-020-04355-6 PMC 바로가기 [Article Type] Letter