Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitisMain Articles Published on 2021-04-302022-10-30 Journal: The Journal of laryngology and otology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 chemokine Ciliated epithelial cells controls coronavirus Coronavirus-2 correlated Eosinophilic eosinophils eotaxin-3 ethmoid sinus examined expression immunoreactivity Infection Inflammation Inflammatory cytokine interleukin-1β Invasion investigated Messenger RNA mucosa objective paranasal sinus Patient patients polymerase chain positive cell positively correlated pro-inflammatory cytokines Quantitative receptor Regulation respiratory epithelium Result reverse transcription SARS-CoV-2 significant decrease sinusitis specimen susceptibility tumor necrosis factor-alpha tumour necrosis factor-α were assessed [DOI] 10.1017/S0022215121001225 PMC 바로가기 [Article Type] Main Articles
Impaired Humoral Response in Renal Transplant Recipients to SARS-CoV-2 Vaccination with BNT162b2 (Pfizer-BioNTech)Communication Published on 2021-04-252022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome anti-SARS-CoV-2 IgG antibody Antibody Response BNT162b2 CLIA Cohort Coronavirus-2 COVID-19 dose evaluated Germany HCW healthcare worker healthy control humoral immune response Impaired individual investigated Messenger RNA mortality rate mRNA-based mRNA-based vaccine Patient Pfizer-BioNTech positive protocol recipient recipients renal Renal transplant recipients Renal transplantation response SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose significantly lower solid organ transplant SOT tested the patient the SARS-CoV-2 Transplant vaccination Vaccination strategy Vaccine vulnerable patients was determined [DOI] 10.3390/v13050756 PMC 바로가기 [Article Type] Communication
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant PersonsOriginal Article Published on 2021-04-212022-11-01 Journal: The New England Journal of Medicine [Category] COVID-19, [키워드] Adverse adverse event age calculated chills comparable conducted coronavirus disease death enrolled Fever finding Follow-up headache Health incidence initial less Messenger RNA mRNA myalgia Neonatal nonpregnant outcome outcomes Pain pandemic participant Person Pregnancy pregnant pregnant women Preterm birth proportion receiving reported Reporting Result Safety spontaneous abortion Surveillance System the United State used data vaccination Vaccine Vaccines women [DOI] 10.1056/NEJMoa2104983 PMC 바로가기 [Article Type] Original Article
Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA VaccinesMolecular Biosciences Published on 2021-04-202022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] activity Affect affected alteration approved authorisation catastrophic China COVID-19 distribution drug Efficacy EMA emergency situation European Medicines Agency expand FDA food functional General population Genetic immune response Impact in vivo Interaction LNP mechanism Messenger RNA modifications mRNA national health authority pandemic respiratory ribosome SARS-CoV-2 stages target cell Topic understanding Vaccine Vaccines variety viral infection WHO World Health Organization Wuhan [DOI] 10.3389/fmolb.2021.654866 PMC 바로가기 [Article Type] Molecular Biosciences
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
Newborn antibodies to SARS-CoV-2 detected in cord blood after maternal vaccination – a case report산모 예방 접종 후 제대혈에서 SARS-CoV-2에 대한 신생아 항체 검출 – 사례 보고Case Reports Published on 2021-03-222022-09-01 Journal: BMC Pediatrics [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Birth Blood Case report Cord blood coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable Diphtheria during pregnancy Efficacy expected female healthy IgG IgG antibodies Infant Influenza Maternal Messenger RNA mother mRNA naïve Newborn pertussis placental Pregnancy Research respiratory responsible SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody severe acute respiratory syndrome Coronavirus single dose Tetanus vaccination Vaccine virus [DOI] 10.1186/s12887-021-02618-y PMC 바로가기 [Article Type] Case Reports
Bioinformatics and system biology approach to identify the influences of COVID-19 on cardiovascular and hypertensive comorbidities심혈관 및 고혈압 동반 질환에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] ACE inhibitor ACE inhibitors ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus Affect aldosterone angiotensin angiotensin converting enzyme angiotensin I Angiotensin II approach bioinformatics blood pressure blood sample Blood samples Cancer cardiovascular cardiovascular comorbidities cardiovascular comorbidity cardiovascular disease cardiovascular diseases caused Cell cell signalling pathway and ontology cell stress cells chemical compound chemokines chronic heart failure Comorbidity condition convert coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines DEGs diabetes differentially expressed differentially expressed gene Differentially expressed genes disease Diseases drug elevated enzyme expressed expression functions gene regulatory network Genetic heart heart failure help human tissues hypertension hypertensive hypertensive diseases identify immune response gene immune response genes infect infected individual infected individuals Infection influence Interaction interactions intestine kidneys Lung injury Lungs mechanism medication medications Messenger RNA Mortality ontologies Ontology pandemic Pathogenesis pathway Pathways Patient Peripheral blood peripheral blood cell peripheral blood cells receptor reduce Renin renin-angiotensin-aldosterone system Research risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested susceptible System biology T cell target Testis Toll-like receptor Treatment type 2 diabete type 2 diabetes [DOI] 10.1093/bib/bbaa426 PMC 바로가기 [Article Type] Article
Target Product Profile Analysis of COVID-19 Vaccines in Phase III Clinical Trials and Beyond: An Early 2021 Perspective3상 임상 시험 및 그 이후의 COVID-19 백신에 대한 대상 제품 프로필 분석: 2021년 초 전망Review Published on 2021-03-052022-09-10 Journal: Viruses [Category] SARS, 임상, [키워드] Analysis antibody candidate vaccine category cause caused clinical clinical trial Comparative analysis coronavirus coronavirus disease Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic COVID-19 vaccines death destabilized effective effort Emergency use authorization generate globe highlight immune response inactivated initiated less mental health Messenger RNA overcome pandemic phase platform product profile public health SARS-CoV-2 SARS-CoV-2 virus target target product profile team the SARS-CoV-2 virus Trial Vaccine Vaccines Viral Viral vector virus Well-being widespread Wuhan Wuhan, China [DOI] 10.3390/v13030418 PMC 바로가기 [Article Type] Review
[In subjects 16 years of age and older, is messenger RNA vaccine BNT162b2 against COVID-19 effective and safe?][16세 이상 대상자에서 코로나19에 대한 메신저 RNA 백신 BNT162b2가 효과적이고 안전한가요?]Article Published on 2021-03-012022-09-11 Journal: La Revue de médecine interne [Category] SARS, 임상, [키워드] age BNT162b2 COVID-19 effective Messenger RNA Older subject Vaccine [DOI] 10.1016/j.revmed.2021.02.001 PMC 바로가기 [Article Type] Article
Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives메신저 RNA 백신의 나노입자 매개 세포질 전달: 과제 및 미래 전망Review Published on 2021-03-012022-08-31 Journal: Pharmaceutical research [Category] 치료제, [키워드] Cell challenge clinician COVID-19 pandemic cytoplasmic delivery endosomal escape faster followed by Future help immune response induce Intracellular intracellular delivery messenger Messenger RNA mRNA mRNA vaccine mRNA vaccines nanomedicines outlined Perspective physicochemical property profiles provide ribosome ribosomes RNA target Vaccine Vaccines [DOI] 10.1007/s11095-021-03015-x PMC 바로가기 [Article Type] Review