Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
Report
[키워드] ACE2
ACE2 variant
acting
acute respiratory syndrome
addition
affinity
angiotensin-converting enzyme 2
bind
binding
binding affinity
catalytically active
comparable
coronavirus
deep mutagenesis
dimeric
Engineering
host cell
host receptor
human ACE2
human cells
identify
in vitro
Infection
Interaction
limit
monoclonal antibodies
motif
mutant
Mutation
neutralization
neutralize
neutralized
neutralizing antibody
Protein
provide
receptor
receptors
SARS Coronavirus
SARS-CoV-1
SARS-CoV-2
Science
similarity
soluble ACE2
specificity
Spike protein
the SARS-CoV-2
the spike protein
therapeutic
variant
viral escape
virus
[DOI] 10.1126/science.abc0870 PMC 바로가기 [Article Type] Report
[DOI] 10.1126/science.abc0870 PMC 바로가기 [Article Type] Report