Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumoniaArticle Published on 2021-03-042022-10-04 Journal: Science Immunology [Category] Fulltext, SARS, 진단, [키워드] acute respiratory syndrome CD8 Cell characterized coronavirus dampen elevated exacerbated expression fibrosis Heterologous hosts individuals infections Inflammatory influenza viral Influenza virus involved lack Lower lung Lung inflammation Lung pathology memory T cell Pneumonia protective immunity respiratory tract respiratory viral infections severe viral pneumonia Signaling subpopulation Support T cell TCR TGF-β tissue tissues Viral pneumonia [DOI] 10.1126/sciimmunol.abc4557 PMC 바로가기 [Article Type] Article
Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in FerretsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Antigen Body weight loss candidate clearance Clinical symptoms coronavirus CoV COVID-19 demonstrated development disease domain effective ferret ferritin Fever Helicobacter pylori Host host cell immunization induce Infectious virus Interaction intramuscular intranasal lung mammalian cell nanoparticle nasal washe neutralizing antibody organs pandemic produced protective immunity Protein purified RBD RBD-nanoparticle Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection spike the RBD the spike protein Vaccine vaccine candidate Vaccines Viral RNA [DOI] 10.1128/mBio.00230-21 PMC 바로가기 [Article Type] Research Article
Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse ModelResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adenovirus Antigen attribute binding cleavage site Combination coronavirus COVID-19 deleted exchange expresse host cell human Angiotensin-converting enzyme include induce membrane fusion Middle East Model mouse Mutation Neutralizing antibodies polybasic proline proline mutations protective effect protective immunity Protein recombinant removal respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike shown Site spike Spike protein Spike proteins tested trimer Vaccine vaccine candidate Vaccine development while wild-type [DOI] 10.1128/mBio.02648-20 PMC 바로가기 [Article Type] Research Article
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
Recurrent COVID-19 including evidence of reinfection and enhanced severity in thirty Brazilian healthcare workers30명의 브라질 의료 종사자에서 재감염 및 중증도 증가의 증거를 포함한 재발성 COVID-19Observational Study Published on 2021-03-012022-09-11 Journal: The Journal of Infection [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] antibodies assumption Blood blood type case control study case sery case-control studies case-control study chronic infection clinical recovery control group COVID-19 COVID-19 disease COVID-19 patients database de novo defined disease Evidence female first episode Genome sequencing genomic sequence HCW healthcare worker individual Infection initial Isolation one individual one patient Patient phylogenetically positive COVID-19 protective immunity qRT-PCR Randomly recurrence Recurrent reduced Reinfection reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody selected severity short term significantly Symptom symptomatic virus genome [DOI] 10.1016/j.jinf.2021.01.020 PMC 바로가기 [Article Type] Observational Study
COVID-19 vaccines for patients with cancer: benefits likely outweigh risksReview Published on 2021-02-272022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, Fulltext, MERS, [키워드] alteration approved benefit Cancer Cancer therapies candidate clinical trials COVID COVID-19 COVID-19 and cancer COVID-19 case COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Efficacy excitement immune immunomodulatory majority malignancy MOST mRNA Patient Patients with cancer Patients with cancer and COVID-19 Prevent protective immunity question receive Research risk SARS-CoV-2 SARS-CoV-2 virus vaccines Therapies vaccination Vaccine [DOI] 10.1186/s13045-021-01046-w PMC 바로가기 [Article Type] Review
The challenge of avidity determination in SARS‐CoV‐2 serologySARS-CoV-2 혈청학에서 결합력 측정의 도전Research Article Published on 2021-02-192022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Antigen antigens approach avidity characterized Combination complexity Concentration coronavirus described determine differentiation domain IgG IgG response IgG responses immune response Immunoglobulin Immunoglobulin G immunoglobulin M indicate Infection kinetic late stage maturation Neutralizing antibodies nucleoprotein occur optimization positive Probability protective effect protective immunity RBD receptor‐binding domain receptor‐binding domain required respiratory SARS‐CoV‐2 SARS‐CoV‐2 seasonal coronavirus seasonal coronaviruses serological response serology severe acute respiratory syndrome Coronavirus shown Spike protein spike protein S1 suggested to define Treatment urea vaccination virus [DOI] 10.1002/jmv.26863 PMC 바로가기 [Article Type] Research Article
Use of machine learning to identify a T cell response to SARS-CoV-2기계 학습을 사용하여 SARS-CoV-2에 대한 T 세포 반응 식별Article Published on 2021-02-162022-09-11 Journal: Cell Reports Medicine [Category] 치료기술, [키워드] Accuracy adaptive Adaptive immunity antibody Applying approach available data B cell B cell receptor repertoire Beta can not cohorts coronavirus Critical disease heavy chain Hierarchical hierarchical clustering identify IGH Immunoglobulin individual Infection Longevity machine learning natural infection Patient protective immunity receptor repertoire SARS-CoV-2 SARS-COV-2 infection sensitivity sequence sequences specificity T cell T cell receptor T cell receptor repertoire T cell response T cell responses TCR TRB Vaccine-induced immunity [DOI] 10.1016/j.xcrm.2021.100192 PMC 바로가기 [Article Type] Article
Early detection of neutralizing antibodies against SARS-CoV-2 in COVID-19 patients in Thailand태국 코로나19 환자에서 SARS-CoV-2에 대한 중화항체 조기 발견Research Article Published on 2021-02-122022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval biosafety can be used clinically collected COVID-19 patient COVID-19 symptoms detect determine Diagnosis diagnosis of SARS-CoV-2 Early detection IgG antibody IgM/ IgG antibody Indicator Infection interquartile range IQR isotype median Mild mild symptoms moderate NAb NAbs Negative predictive value neutralization activity Neutralizing antibodies neutralizing antibody offer Patient patients PCR-confirmed PCR-confirmed COVID-19 patients positive Predictive value protective immune response protective immunity real-time RT-PCR Receptor binding Receptor binding domain Result robust SARS-CoV-2 SARS-COV-2 infection sensitivity serological test severity of COVID-19 significantly higher specificity specimen surrogate viral neutralization assay sVNT Symptom symptom onset the patient Viral viral infections viral neutralization weakly positive [DOI] 10.1371/journal.pone.0246864 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamstersSARS-CoV-2 감염은 보호 면역을 유도하고 시리아 햄스터의 전파를 제한합니다Research Article Published on 2021-02-112022-09-12 Journal: Life Science Alliance [Category] MERS, SARS, 진단, [키워드] accompanied caused close contact Critical death demonstrated develop effective vaccine Effective vaccines hamster hamsters help Immunity induce infections initial intranasal Laboratory limit Log reduction lung Lungs Median viral load morbidity MOST naïve nasal washe natural infection Neutralizing antibodies Prevent PROTECT protective immunity public health question recovered patient recovered patients Reinfection representing SARS-CoV-2 SARS-COV-2 infection severe disease significantly TCID Transmission Vaccine development viral clearance Viral pneumonia virus [DOI] 10.26508/lsa.202000886 PMC 바로가기 [Article Type] Research Article