Risk factors for severe disease in patients admitted with COVID-19 to a hospital in London, England: a retrospective cohort studyOriginal Paper Published on 2020-10-132022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] adjusted hazard ratio alkaline phosphatase association blood test C-reactive protein caused Chest Clinical outcome clinical risk Comorbidities country COVID-19 Cox proportional hazard Critical death demographics Factor global pandemic hospital hospitalisation hospitalised patient hypoxia Immunosuppression independent Lactate London Mortality mortality rate Observational cohort study pandemic progresses park Patient patients Platelet Primary outcome public health Research Respiratory disease respiratory rate retrospective cohort study risk factor scale severe disease Stratification understanding urea with COVID-19 [DOI] 10.1017/S0950268820002472 PMC 바로가기 [Article Type] Original Paper
A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-10-062022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 active cancer addition administration age ambient analysed anti-SARS-CoV-2 Antibody titer antibody titres anticipated ARMS assessment baseline Blinding Block randomisation breathing ambient air case report form changes in Chemotherapy clearance clinical clinical condition Clinical outcome collected Confirmed Contact convalescence convalescent plasma COVID-19 criteria cross cytokine profile D-dimer death defined described diagnostic discharge discharged patient dissemination Donor Duration early application eCRF Effect element eligibility eligible eligible patient Enrollment EudraCT exclusion criteria expected experimental arm exploratory feature Follow-up follow-up period group Hematological malignancy high risk high-risk patient high-risk patients with severe disease hospital Hospital admission Hospital stay Hospitalized Immunosuppression inclusion criteria Infection infusion investigator laboratory data Last less mechanical ventilation multicenter non-parametric test number objective Open-label outcome overall survival participant Patient performed plasma positive protocol quarter Radiotherapy randomisation randomised randomised controlled trial randomization system Randomized receive recruitment Registered report reported required Requirement risk routine care Sample size SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 viral schedule secondary Secondary objective Seven seven-point ordinal scale Standard Standard of care status Stratification Study protocol subject survival survival rate survival rates Swab table the patient therapy time Total treated Treatment Trial underlying disease Viral load website worsening [DOI] 10.1186/s13063-020-04735-y PMC 바로가기 [Article Type] Letter
Machine learning based early warning system enables accurate mortality risk prediction for COVID-19Article Published on 2020-10-062022-10-04 Journal: Nature Communications [Category] MERS, SARS, 임상, 치료법, [키워드] Admission AUC Clinical data cohorts coronavirus disease COVID-19 COVID-19 crisis COVID-19 patients death decision Deterioration external validation facilitate Gradient Health health system high risk machine machine learning mitigate Mortality mortality risk network Neural pandemic Patient patients with COVID-19 physiological Prognostic markers Regression resource Risk factors Stratification support vector machine tree validation cohort viral infection [DOI] 10.1038/s41467-020-18684-2 PMC 바로가기 [Article Type] Article
A Pattern Categorization of CT Findings to Predict Outcome of COVID-19 PneumoniaPublic Health Published on 2020-09-182022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Admission admitted to ICU adverse outcome age analyzed bronchopneumonia C-reactive protein categories categorization Chest CT Clinical characteristics Clinical finding Clinical outcome clinical outcomes Comorbidity Complete Computed tomography correlated correlation COVID-19 CT finding CT pattern death died Diffuse alveolar damage discharge discharged disease severity enrolled Evolution facilitate finding global healthcare hazard-ratio ICU IMPROVE laboratory result management mechanical ventilation median men novel coronavirus disease Organizing pneumonia outcome Patient patients with COVID-19 pattern Pneumonia predict prognostic progression pulmonary sequelae remained required risk risk factor Significant significantly Stratification survival symptom onset [DOI] 10.3389/fpubh.2020.567672 PMC 바로가기 [Article Type] Public Health
Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in DenmarkLetter Published on 2020-09-172022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 24 hour Administered administration age All participant allergy anti-cytokine therapy approved asked Bacterial infection BCG BCG vaccination blinded to treatment block Bone marrow Chemotherapy component Controlled trial COVID-19 COVID-19 pandemic criteria cumulative current daily dose Day defined Denmark Direct dissemination dose Effect element eligible ENhance EudraCT excluded exclusion group HCW Health care Health care worker HIV-1 hospital Hospital admission hospitals Human immunodeficiency virus Immunocompromised immunodeficiency incidence Inclusion infected with SARS-CoV-2 Infection infections Infectious disease injection Intervention intravenous lymphoma malignancy Medicine meet morbidity and mortality mycobacterial Mycobacterium tuberculosis NaCl solution non-specific not blinded number participant physician Placebo Prednisone Prevent protective effect protocol random randomisation randomised randomised controlled trial receive recruit reduce reductions in Registered reported resuspended Sample secondary Serious Adverse Event severity of COVID-19 Sex solid organ transplantation steroid Stratification study participant Study protocol subject subjects susceptibility suspicion Treatment Trial Tuberculosis Vaccine Vaccines website [DOI] 10.1186/s13063-020-04714-3 PMC 바로가기 [Article Type] Letter
Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality ScoreResearch Published on 2020-09-092022-10-28 Journal: The BMJ [Category] COVID-19, Fulltext, SARS, [키워드] 4C mortality score 95% confidence interval age applicability C reactive protein can be used CCP-UK characteristic clinical clinical decision Cohort cohort of patient conducted coronavirus disease data extraction dataset determine develop eight England Final groups hospital initial ISARIC less management Model Mortality mortality rate Negative predictive value number of comorbidities objective Observational cohort study outcome measure parameter participant Patient performed peripheral oxygen saturation populations Positive predictive value Pragmatic predict Prospective recruited respiratory respiratory rate Result risk risk stratification score setting Sex Stratification urea utility variable was performed WHO World Health Organization [DOI] 10.1136/bmj.m3339 PMC 바로가기 [Article Type] Research
A cross-sectional study of psychological wellbeing of Indian adults during the Covid-19 lockdown: Different strokes for different folksResearch Article Published on 2020-09-032022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] adjusted Adults Analysis Comorbidities Comorbidity Complication covariates cross-sectional extreme Frequency greater group groups higher risk identify India LGBT linear lockdown logistic regression model mental illness pandemic Person physical Psychological psychological Impact Qualitative Quantitative reported Sociodemographic Stratification stroke suggested [DOI] 10.1371/journal.pone.0238761 PMC 바로가기 [Article Type] Research Article
COVID-19 pandemics modeling with modified determinist SEIR, social distancing, and age stratification. The effect of vertical confinement and release in BrazilResearch Article Published on 2020-09-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval age Algorithm Analysis Asymptomatic Brazil Care Contact Contamination country COVID-19 death Epidemics example fatality feasibility group groups Health Hospitalization hospitalizations ICU increased risk individual lockdown magnitude Markov chain Older Pandemics parameter quarantine reduced resulting SARS-COV-2 infection SEIR severe disease social distancing Stratification Transmission [DOI] 10.1371/journal.pone.0237627 PMC 바로가기 [Article Type] Research Article
Identification of risk factors for mortality associated with COVID-19Epidemiology Published on 2020-09-012022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 1.26 95% CI Accuracy Algorithm Analysis Cohort collected conducted COVID-19 COVID-19 patients develop Final Genetic Genetic algorithms Hospital admission hospital discharge identification linear models Linear regression logistic regression models Lymphocyte count median Mortality mortality rate objective Older outbreak pandemic patients with COVID-19 predictor Primary outcome Protein resource Result risk factor selected significantly statistical significance Stratification Survivors troponin I variable vital status with COVID-19 Wuhan α-Hydroxybutyrate dehydrogenase [DOI] 10.7717/peerj.9885 PMC 바로가기 [Article Type] Epidemiology
Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patientsResearch Article Published on 2020-08-312022-10-28 Journal: BMC Medical Research Methodology [Category] COVID-19, Fulltext, MERS, [키워드] addition binary variable calculated clinical trial Clinical trial design composite endpoint Composite outcomes COVID-19 COVID-19 patient detect discharged effect size Efficacy Factor feature greater groups hospital Hospitalization independent Interim analyses interim analysis Intervention intubation Mortality mortality rate outcome outcome measures Patient patients phase power proportion reduction in mortality required response variable Result risk Sample Sample size Stage Stratification therapeutic intervention Toxicity Toxicity monitoring treatable Treatment vulnerable patients World Health Organization [DOI] 10.1186/s12874-020-01101-z PMC 바로가기 [Article Type] Research Article