SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infectionSARS-CoV-2 백신 접종은 이전 SARS-CoV-2 감염 환자에서 CD4+ 스파이크 반응성 T 세포 레퍼토리를 다양화합니다.Article Published on 2022-06-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated analyzed B cell response CD4+ CD4+ T cell CD4+ T cells clone common cold coronavirus coronavirus Coronaviruses COVID-19 COVID-19 convalescent patient COVID-19 disease demonstrated elicit expansion foundation healthy donor identify immune response induce Johns Hopkins University Melinda Gate mRNA mRNA vaccination mRNA vaccine naïve natural infection NIH Patient patients Post-vaccine question reactive receptor recipients response SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 vaccination Specific spike glycoprotein stimulated T cell T cell receptor the SARS-CoV-2 the vaccine vaccination Vaccine [DOI] 10.1016/j.ebiom.2022.104048 PMC 바로가기 [Article Type] Article
Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] antigenic approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines validation variant variants was performed [DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article
An insight to the therapeutic potential of algae-derived sulfated polysaccharides and polyunsaturated fatty acids: Focusing on the COVID-19Review article Published on 2022-06-012022-10-05 Journal: International journal of biological macromolecules [Category] 변종, 치료제, [키워드] addition affected Algae candidate Compound coronavirus COVID-19 COVID-19 case Critical Effectiveness fatty Fatty acid Focusing Gut gut microbiome Health immune regulation immune system immunomodulatory activities immunomodulatory property Infection infections intestine Microbiome microbiota modulate modulating modulation Mutation nutritional intervention other organ pandemic Polyunsaturated Polyunsaturated fatty acids Prevent produced Research resources response sulfated polysaccharide sulfated polysaccharides the vaccine therapeutic therapeutic potential these compound Treatment Vaccine viral infections virus virus pathogenesis [DOI] 10.1016/j.ijbiomac.2022.03.063 [Article Type] Review article
The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled TrialRandomized Controlled Trial Published on 2022-05-302022-10-04 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Administered adoption Adults age altruism applied assigned booster Canadian change changes in chi-square test Controlled COVID-19 COVID-19 vaccination COVID-19 vaccine deaths demonstrated Digital health digital intervention Diseases Efficacy Enhancing evaluate Health health information health intervention Health promotion Hospitalization Intention Intervention Measures media Model not significant Older online health pandemic participant Pearson performed postintervention Precaution Process prosocial motives provide public health public health authority Randomized Randomized controlled trial RCT receive receiving recommendation recruited reducing Research Sample the vaccine thought Trial vaccinate vaccinated against COVID-19 vaccination Vaccine Vaccine hesitancy vaccine intention vaccine intentions video intervention virus was performed web survey were assessed younger adults Youth [DOI] 10.2196/37328 PMC 바로가기 [Article Type] Randomized Controlled Trial
Vaccination With Oral Polio Vaccine Reduces COVID-19 Incidence경구용 폴리오 백신 접종이 COVID-19 발생률을 감소시킨다.Randomized Controlled Trial Published on 2022-05-302022-10-05 Journal: Frontiers in Immunology [Category] 임상, 폴리오, [키워드] absence Acute respiratory infection Alter ARI Bacterial pathogens clinical clinically complement conducted Coronavirus vaccines Course COVID-19 COVID-19 cases develop diagnosed Effects emerging diseases Endpoint etiology evaluate the effect groups healthy volunteer heterogeneous Hypothesis immunization immunized in both group incidence incidence of COVID-19 induce infections innate immune responses Innate immunity Laboratory laboratory-confirmed Live attenuated vaccine non-specific non-specific protection observation OPV oral pandemic parallel-group participant pathogen Placebo protective effect Randomized reduced Region Respiratory illness SARS-CoV-2 Seasonal influenza shown significantly significantly lower single dose statistically significant study participant the vaccine threat Trial registration two group university Vaccine vaccine off-target effects. [DOI] 10.3389/fimmu.2022.907341 PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety and Efficacy of Combined Intramuscular/Intranasal RAZI-COV PARS Vaccine Candidate Against SARS-CoV-2: A Preclinical Study in Several Animal ModelsSARS-CoV-2에 대한 결합된 근육내/비강내 RAZI-COV PARS 백신 후보의 안전성 및 효능: 여러 동물 모델에서의 전임상 연구Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence adjuvant administration Against Amino acid animal approval BALB/c mice blood chemistry candidate candidate vaccine Cellular immune response changes in clearance Combined control group COVID-19 different dose dose Efficacy Efficacy and safety evaluated hamster hamsters heterologous prime-boost High dose humoral IgA antibody immune immune response Immunity induce interval intramuscular intranasal intranasally Iran lung Lung pathology Lungs mice middle Model Modification monomeric mucosal N-terminal domain Neutralizing antibodies New NTD organs parameters Pathological examination pfu Placebo Preclinical Protective RAZI-COV PARS RBD regimens repeated robust Safety SARS-CoV-2 SARS-CoV-2 preclinical study SARS-CoV-2 spike protein significantly specific IgG antibody Spike protein Spread stimulated subunits tested the vaccine trimer vaccination Vaccine vaccine candidate viral infection virus virus load was performed [DOI] 10.3389/fimmu.2022.836745 PMC 바로가기 [Article Type] Article
Theoretically quantifying the direct and indirect benefits of vaccination against SARS-CoV-2 in terms of avoided deaths사망 방지 측면에서 SARS-CoV-2 백신 접종의 직간접적인 이점을 이론적으로 정량화Article Published on 2022-05-252022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] a metric accompanied Affect basic reproduction number benefit changed changes in Community coronavirus disease Coronavirus disease 2019 death deaths Effectiveness example framework Hope hospitalisation in some individual initial metric mortality rate occur offer pandemic parameter Prevalence respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome virus Spike protein susceptible individual Taking text the disease the spike protein the vaccine vaccinated individuals vaccination vaccination rate Vaccine Vaccines variant virus [DOI] 10.1038/s41598-022-12591-w PMC 바로가기 [Article Type] Article
Longitudinal analysis of anti-SARS-CoV-2 S-RBD IgG antibodies before and after the third dose of the BNT162b2 vaccineBNT162b2 백신의 3차 접종 전후에 항-SARS-CoV-2 S-RBD IgG 항체의 종단적 분석Article Published on 2022-05-232022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis anti-SARS-CoV-2 Anti-spike antibody antibody level Antibody Response baseline BNT162b2 vaccine COVID-19 vaccine decrease domain dose doses Efficacy evaluate female healthy individual IgG IgG antibody IgG level Immunity Immunological response immunosurveillance independent indirect chemiluminescence immunoassay individual induce Infection longitudinal males naïve Protein reactivity recipients respiratory response S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 infection Sex SNIBE Steady state Support the vaccine Trigger Vaccine vaccine doses [DOI] 10.1038/s41598-022-12750-z PMC 바로가기 [Article Type] Article
Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemicCOVID-19 대유행 전과 동안, 동반이환 및 예방접종 상태에 따른 개인의 사회적 접촉의 시간 경향Article Published on 2022-05-232022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95%CI analyses Analysis booster dose booster doses Canada Christma Comorbidities Comorbidity Complication conducted Contact COVID-19 COVID-19 complications COVID-19 pandemic COVID-19 vaccination cross-sectional described distance Efficacy explained first dose First wave Generalized linear model greater Immune escape individual Infectious diseases Intervention masking medical condition medication MONITOR outcome pandemic participant performed physical contact Poisson distribution Public public health Quebec, Canada questionnaire random recruited repeated risk of COVID-19 robust second wave significant difference significantly social contact Social contacts the mean the vaccine time used data vaccination Vaccination Status Vaccine vaccine efficacy variant [DOI] 10.1186/s12916-022-02398-x PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific immune responses in boosted vaccine recipients with breakthrough infections during the Omicron variant surge오미크론 변이체 급증 동안 돌발 감염이 있는 부스트 백신 수혜자의 SARS-CoV-2 특이적 면역 반응Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Adaptive immunity allergy analyzed antibody binding booster Breakthrough infection breakthrough infections cellular response Cellular responses COVID-19 ELISpot assay funds healthy Humoral immunity immune response immune responses Infection Infectious disease inhibited Johns Hopkin Johns Hopkins less levels of antibodies levels of antibody median mRNA vaccine National Cancer Institute occur omicron Omicron variant Protein Protein binding receiving recipient recipients robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-specific immune response significantly Spike protein Spike proteins supported T cell T cell response T cells the vaccine vaccinated individual vaccinated individuals Vaccine vaccine strain variant variant spike [DOI] 10.1172/jci.insight.159474 PMC 바로가기 [Article Type] Article