Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
Research Article
[키워드] absence
antibodies
Betacoronavirus
caused
cellular
coronavirus
CoV
CoVs
cultured cells
Effect
genomic
genomic RNA
gRNA
IFN
IFNAR
in viral
in vitro
in vivo
increases in
Infection
innate immune
innate immune response
innate immune system
interferon
interferon response
interferon signaling
locus
marrow-derived macrophage
MAVS
mechanism
MHV
mice
murine hepatitis virus
mutant
mutant virus
Mutation
not affect
Nsp15
ORF1b
packaged
packaging signal
Pathogenesis
pathogenicity
positive
positive-sense
promote
receptor
reduced
remained
replicated
Replication
required
response
restored
RNA
RNA molecule
RNA packaging
RNAs
selective
selective packaging
significantly
strain
subgenomic RNAs
These data
TLR7
treated
Type
virion
virions
virulence
virus
virus replication
viruses
weight loss
[DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article