Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV)Research Article Published on 2016-06-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] acid Additive cause Cell Concentration Contaminated control sample decrease diarrhea dose effective epidemic diarrhea feed additive high mortality inactivation Inclusion incubated kinetic log parameter PEDV processing produced ranged reduce reduced reducing required selected sugar suggested Survivability survival temperature tested thermal vehicle of transmission virus virus inactivation virus titer vomiting Weibull distribution [DOI] 10.1371/journal.pone.0158128 PMC 바로가기 [Article Type] Research Article
Global research trends of Middle East respiratory syndrome coronavirus: a bibliometric analysisResearch Article Published on 2016-06-072022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] activity acute respiratory syndrome Analysis article articles average Bibliometric cause Characteristics clinical symptom coronavirus country database exhibited Germany high mortality rate highest humans include International Kingdom MERS-CoV Metrics Middle East Middle East respiratory syndrome Coronavirus outbreak parameter produced proportion rapid increase Region Research respiratory syndrome coronavirus Result Saudi Arabia Scopus searched severe viral pneumonia similarity Spread syndrome USA virus was performed were excluded [DOI] 10.1186/s12879-016-1600-5 PMC 바로가기 [Article Type] Research Article
Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?Research Article Published on 2016-05-032022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, [키워드] addition asymptomatic infections candidate cause clone coronavirus demonstrated fatal disease Feline infectious peritonitis genetic diversity genetic marker M gene marker mutant spectrum producing Protein responsible sequenced strain suggested unique virulent virus widespread [DOI] 10.1155/2016/8560691 PMC 바로가기 [Article Type] Research Article
Reverse Transcription Cross-Priming Amplification–Nucleic Acid Test Strip for Rapid Detection of Porcine Epidemic Diarrhea VirusArticle Published on 2016-04-192022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acid amplification amplification product applied binding antibody cause conducted contribute coronavirus detection Detection limit detection system disease effective epidemic diarrhea evaluated N gene Neonatal nucleic acid test offer PCR PCR method PEDV Plasmid primer probe Rapid Result reverse transcription RNA sensitivity sequence specimens strip target gene Test virus were used [DOI] 10.1038/srep24702 PMC 바로가기 [Article Type] Article
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease InhibitorResearch Article Published on 2016-03-302022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 3CLpro Animal coronaviruses Antiviral compound antiviral drug antiviral drugs Antiviral treatment cause caused cell tropism contributed coronavirus Coronavirus infection Coronavirus infections Cross-species transmission death disease Diseases effective Efficacy and safety evaluated experimental evidence facilitate fatal disease fatality feature Feline infectious peritonitis Fever full recovery Health Host Human humans immune response Immune-mediated infect inflammatory disease inhibitor Laboratory less lymphopenia mammalian measure Mild Mutation other coronavirus pathogen Pathogenesis progression protease Protease inhibitor recombination rate reduction in Replication reported required respiratory resulting returned reversal risk Significant T cells therapeutic therapeutic efficacy therapeutic strategy tissue Treatment viable treatment viral titer virulence virulent virus virus replication [DOI] 10.1371/journal.ppat.1005531 PMC 바로가기 [Article Type] Research Article
The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cellsResearch Paper: Immunology Published on 2016-03-152022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] Actin activating binding cascade cause cell membrane cofilin coronavirus decrease diarrhea disrupt downstream EGFR epidermal F-actin gastroenteritis growth factor GTPases high mortality Host immune response Immunity Immunology and Microbiology Section Infection inhibit inhibition intestinal epithelial cell intestinal epithelium involved MAPK mechanism Newborn Pathogenesis Phosphorylation PI3K platform promote Protein receptor regulate responsible Signaling signaling pathway Spike protein stimulate TGEV transmissible gastroenteritis virus upstream virus entry [DOI] 10.18632/oncotarget.7723 PMC 바로가기 [Article Type] Research Paper: Immunology
Genomic Motifs as a Novel Indicator of the Relationship between Strains Isolated from the Epidemic of Porcine Epidemic Diarrhea in 2013-2014Research Article Published on 2016-01-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Analysis application applied approach Canada cause China Chinese connection country epidemic diarrhea epidemiological explicit gastroenteritis Genome genome sequence Germany identify Inconclusive increasingly Indicator Interpretation Isolated isolates Japan motif novel occurred outbreak PEDV Phylogenetic tree positive-sense RNA virus relationship reported selected strain Strains the disease the United State Transmission USA virus whole genome sequence [DOI] 10.1371/journal.pone.0147994 PMC 바로가기 [Article Type] Research Article
The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombinationArticle Published on 2016-01-062022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] cause caused characterized Chinese clade coding regions Complete country Genome genome sequence geographical region isolates Korean less MERS-CoV Middle East outbreak Phylogenetic relationship Protein recombinants Recombination reconstructed remained reported Respiratory disease respiratory syndrome coronavirus sequence Severe case strain Strains unique [DOI] 10.1038/srep18825 PMC 바로가기 [Article Type] Article
Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-CoronavirusResearch Article Published on 2015-12-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accompanied addition animal model antiviral agent Autopsy Brain cause damage Dipeptidyl peptidase 4 Efficacy evaluate exhibited expressing hDPP4 high mortality Human Infection Injury intranasal kidney liver lung Lungs Macrophage infiltration mechanism MERS-CoV MERS-CoV infection mice Middle East Mild Multi-organ damage Neuron neutrophil organ paralysis Pathogenesis peptidase positive Post-infection receptor respiratory Respiratory failure severe pneumonia spleen Symptom systemic inflammation the disease Transgenic mouse Vaccine viral burden viral replication [DOI] 10.1371/journal.pone.0145561 PMC 바로가기 [Article Type] Research Article
Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014Expedited Published on 2015-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Admission Affect age cause clinical outcomes Clinical severity cycle threshold death decrease determine died E gene evaluated intensive care load median MERS-CoV Middle East Middle East respiratory syndrome Coronavirus modulation multivariable nasopharyngeal specimen outcome Patient patients positive Regression analyses respiratory syndrome coronavirus Result reverse transcription PCR risk factor Saudi Arabia significantly lower survivor tested the median therapeutic agent upstream virus virus load viruses zoonoses [DOI] 10.3201/eid2111.150764 PMC 바로가기 [Article Type] Expedited