The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birdsResearch Article Published on 2015-10-092022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Affect analysed Bacterial infection biological pathway can be used candidate gene cause chicken contagious coronavirus disease Disease resistance Effect evaluated examined expression functional Gene Expression gene expression differences Genetic Genome help Host host response IBV IBV infection identify immune response Infection Infectious Bronchitis Virus innate immune response involved lesion Microarray Mortality occur Post-infection Potential reproductive resistance gene Respiratory disease responsible Result selective subsequent supplementary material susceptible target the disease tissue tracheal vaccination virus were used [DOI] 10.1186/s12917-015-0575-6 PMC 바로가기 [Article Type] Research Article
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant HepatitisResearch Article Published on 2015-09-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type [DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primatesArticle Published on 2015-09-042022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome antigen-specific neutralizing antibody antiviral therapy approved Arabian Peninsula cause caused cellular immunity characteristic Consensus coronavirus deaths disease DNA vaccine Europe exhibited increase in induce Infection lack Lineage macaque macaques MERS MERS coronavirus MERS spike protein MERS-CoV mice Middle East morbidity Mortality nosocomial pathogen Pneumonia Prevent protective immunity protective response Protein Radiographic respiratory syndrome coronavirus rhesus macaque route of infection SARS-CoV seroconverted syndrome The United States Transmission treat Vaccine viral challenge virus-neutralizing [DOI] 10.1126/scitranslmed.aac7462 PMC 바로가기 [Article Type] Article
Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak controlReview Published on 2015-08-282022-10-31 Journal: Experimental & Molecular Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome approved can be used cause clinically Coronavirus infection cough death deaths develop drug target Fatality rate Fever Health highlight hospital Human infected individuals infections MERS-CoV MERS-CoV infection Middle East Multiorgan dysfunction Occurrence outbreak raised reported respiratory syndrome coronavirus respiratory tract infection South Korea spread to syndrome therapeutic targeting thought Transmission transmitted virus [DOI] 10.1038/emm.2015.76 PMC 바로가기 [Article Type] Review
Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27Article Published on 2015-08-182022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis antibody assist binding binding site biochemical carbohydrate cause Critical DPP4 epitope Fab fragment Human Human monoclonal antibody inhibit interact Interaction membrane fusion MERS-CoV MERS-CoV infection MERS-CoV RBD Middle East molecular basis mortality rate neutralization neutralization activity overlap RBD receptor Receptor binding Receptor binding domain reported residue residues respiratory syndrome coronavirus severe respiratory illness spike glycoprotein the RBD viral entry [DOI] 10.1038/srep13133 PMC 바로가기 [Article Type] Article
Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in InfancyNBAS의 이대립유전자 돌연변이는 유아기에 발병하여 재발성 급성 간부전을 유발합니다Report Published on 2015-07-022022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] acute infantile liver failure acute liver failure ALF Analysis biallelic mutation biallelic mutations cause childhood compound heterozygous mutation compound heterozygous mutations condition Endoplasmic reticulum Exome exome sequencing Fever fever-dependent RALF FIVE Golgi Immunoblot analysis individual infancy interaction partner involved life-threatening emergency liver liver failure molecular cause mutant fibroblast mutant fibroblasts NBAS Onset protein level RALF Recurrent reduced retrograde transport Sanger sequencing triggered [DOI] 10.1016/j.ajhg.2015.05.009 PMC 바로가기 [Article Type] Report
Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulenceShort Report Published on 2015-06-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] C-terminus cause characterized China Complete contagious disease epidemic diarrhea finding Genome high mortality rate identification indicated Mild Newborn North America pathogenicity pathology PEDV Phylogenetic tree Porcine epidemic diarrhea virus prevalent reduced Reduced virulence S gene spike gene Spread strain variant Vero Cell virulence virus was used [DOI] 10.1186/s12985-015-0314-4 PMC 바로가기 [Article Type] Short Report
Phylodynamic analysis of avian infectious bronchitis virus in South AmericaShort Communication Published on 2015-06-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] America Analysis Asia bronchitis cause coding region coronavirus full-length Genetic Genotype genotypes IBV Infectious Bronchitis Virus introduced isolate Lineage Massachusett N gene performed sequence South South America strain Strains the vaccine virus [DOI] 10.1099/vir.0.000077 PMC 바로가기 [Article Type] Short Communication
Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)Research Article Published on 2015-04-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] accelerated acute respiratory illness amplicons amplification Amplification assay amplify applied assays asymmetric cause coronavirus cross-react detect detection diagnostics E gene facilitate Frame genomic infected cell culture Infection infections isothermal amplification loci management MERS-CoV Middle East mortality rate ORF1b gene plaque forming unit point-of-care primer probe reported respiratory Respiratory pathogens respiratory syndrome coronavirus resulting reverse transcription RT-LAMP supernatant upstream [DOI] 10.1371/journal.pone.0123126 PMC 바로가기 [Article Type] Research Article
Viral gastroenteritis in children in Colorado 2006–2009Research Article Published on 2015-03-162022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] acute gastroenteritis Adenovirus age cause children circulating coronavirus demonstrated determine Diagnosis Epidemiology Evidence FIVE gastroenteritis Immunocompromised Immunocompromised patient Inc incidence indicated male median Microscopy Multiple multiplex Norovirus outbreak Patient pediatric Periodicals positive positive sample reverse transcription PCR RT‐PCR RT‐PCR shedding Stool Strains submitted Support symptomatic Viral gastroenteritis virus were used [DOI] 10.1002/jmv.24022 PMC 바로가기 [Article Type] Research Article