Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in KoreaArticle Published on 2019-04-052022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Care caused cell-free DNA circulating collected Decreased dialysis Effect extreme genomic Hemodialysis highest Isolation marker MERS MERS-CoV Middle East outbreak Patient patients significantly Stress syndrome Treatment undergo was performed [DOI] 10.1038/s41598-019-41964-x PMC 바로가기 [Article Type] Article
What is mutation? A chapter in the series: How microbes “jeopardize” the modern synthesis돌연변이 란 무엇입니까? 시리즈의 한 장: 미생물이 현대 합성을 "위태롭게"하는 방법Review Published on 2019-04-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated assumed Bacteria cancer development chance change Clusters Evolution function Genes genomes genomic Infectious disease life Local mechanism microbe molecular mechanism molecular mechanisms Mutagenesis Mutation occur Protein regulated response Stress stress responses translated tree tree of life up-regulated [DOI] 10.1371/journal.pgen.1007995 PMC 바로가기 [Article Type] Review
Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans미토콘드리아와 식단 사이의 상호 작용은 Caenorhabditis elegans에서 병원체와 스트레스 저항을 매개합니다Research Article Published on 2019-03-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect alleviation Amino acid amino acid metabolism Anemia arise B12 bacterial pathogen Bacterial pathogenesis Bacterial pathogens biochemical Caenorhabditis canonical clearance cofactor condition Critical Defense deficiency demonstrated diet E . coli elegan elegans excess exhibited exposure to Genetic Health homeostasis Host host defense improvement Improvements Increasing independent independent of Interaction intermediate knockdown Laboratory Loss metabolism methylmalonyl-CoA microbiota mitochondrial mitochondrial dysfunction neurological defects organism overexpression pathogen pathogenic Pathogens Pathways phenotype physiological propionate RNAi-mediated gene sensitivity Stress Support survival susceptibility variety vitamin B12 vitamin B12 deficiency were used worm worms [DOI] 10.1371/journal.pgen.1008011 PMC 바로가기 [Article Type] Research Article
Infant cortisol stress-response is associated with thymic function and vaccine responseArticle Published on 2019-01-312024-09-02 Journal: Stress [Category] 파상풍, [키워드] cortisol Stress T-cell thymus Vaccine vitamin A PMC 바로가기
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article
Longitudinal study of age-specific pattern of coronavirus infection in Lyle’s flying fox ( Pteropus lylei ) in ThailandResearch Published on 2018-02-202022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] alphacoronavirus Analysis average bat bats BCI Betacoronavirus Chiroptera conserved coronavirus Coronavirus infection CoV CoV infection CoVs Gender highly pathogenic Human Infection Juvenile longitudinal study mother novel virus outbreak Phylogenetic analysis positive Prevalence Pteropus RdRP RdRp gene rectal swab reservoir responsible Result RNA-dependent RNA polymerase RT-PCR S1 and S2 Sequencing significantly lower Stress Thailand Transmission uninfected viral reactivation viral shedding was used [DOI] 10.1186/s12985-018-0950-6 PMC 바로가기 [Article Type] Research
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
Structural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanismArticle Published on 2017-09-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] addition Analysis Antiviral binding free energy binding mechanism Contact dsRNA engage exhibit explained highlight host immune system host’s immune system immune evasion investigated Mask mechanism MERS-CoV MERS-CoV protein 4a Middle East molecular Multiple p4a pharmacophore Protein Proteins recognize recognizing residue residues respiratory syndrome coronavirus response stability Stress Structural analysis suggested type 1 interferon variant viral dsRNA α1 helix [DOI] 10.1038/s41598-017-11736-6 PMC 바로가기 [Article Type] Article
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article