Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)Article Published on 2020-08-112022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] acute renal failure acute respiratory distress Administered administration Adrecizumab adrenomedullin antibody approach ARDS C-reactive protein calculated capillary leakage case sery coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill died discharged Efficacy eight endothelial function Endothelium expected FIVE Follow-up HAM 8101 High-dose highest humanized ICU Ill inflammatory parameter intensive care interleukin-6 life-threatening low-dose mechanical ventilation median monoclonal Mortality outcome paO2/fiO2 Patient patients procalcitonin ranged renal replacement therapy resource risk Sepsis Seven severity Shock single dose small sample size SOFA SOFA score suffered surviving patient syndrome targeting the disease the patient therapeutic Vascular with COVID-19 [DOI] 10.3390/biom10081171 PMC 바로가기 [Article Type] Article
Mitigation of Aerosols Generated During Rhinologic Surgery: A Pandemic-Era Cadaveric Simulation비뇨기과 수술 중 생성된 에어로졸의 완화: 유행병 시대의 사체 시뮬레이션Sinonasal Disorders Published on 2020-08-112022-08-31 Journal: Otolaryngology--Head and Neck Surgery [Category] MERS, 치료제, [키워드] aerosol aerosol particles aerosol-generating procedure aerosolization Aerosols airborne cadaver characterized Clinical practice Concentration condition COVID-19 COVID-19 pandemic effective electrocautery endonasal drilling endoscopic sinus surgery Health care Health care worker health care workers highest increases in Intervention Laboratory Mitigation objective optical produced quantified reducing Result risk SARS-CoV-2 SARS-CoV-2 transmission setting Significant Simulation sinus surgery skull base surgery smoke statistical significance statistically significant suction surgical Transmission [DOI] 10.1177/0194599820951169 PMC 바로가기 [Article Type] Sinonasal Disorders
Virtual screening, molecular docking studies and DFT calculations of FDA approved compounds similar to the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenzArticle Published on 2020-08-112022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] acute respiratory syndrome approved calculated Compound compounds coronavirus COVID-19 COVID-19 disease COVID-19 infection docking drug-likeness efavirenz FDA FDA approved drug FIVE functional highest HIS163 His41 HIV inhibitor interacting residue Interaction lowest molecular Molecular docking study NNRTI performed pharmaceutical Pharmaceutical chemistry Phe140 podophyllotoxin protease protease inhibitors SARS-CoV-2 selected Theoretical chemistry transcriptase treat Virtual screening virus worldwide pandemic [DOI] 10.1016/j.heliyon.2020.e04642 PMC 바로가기 [Article Type] Article
High seroprevalence of SARS-CoV-2 in elderly care employees in SwedenResearch Article Published on 2020-08-052022-10-29 Journal: Infection Ecology & Epidemiology [Category] COVID-19, [키워드] analyzed antibody Antibody testing asymptomatic infections Care Clinical symptoms correlation COVID-19 COVID-19 pandemic death decrease disease effort elderly care homes Employees Fever highest IgG IgM IgM and IgG immune Infection Logistic Loss of Smell pandemic positive problems quarantine Rapid test SARS-CoV-2 secondary secure seropositive Spread Surveillance Swedish Symptom tested [DOI] 10.1080/20008686.2020.1789036 PMC 바로가기 [Article Type] Research Article
Public perspectives on protective measures during the COVID-19 pandemic in the Netherlands, Germany and Italy: A survey studyResearch Article Published on 2020-08-052022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] applied caused Community Complete Containment measure Containment strategy coronavirus disease coronavirus SARS-CoV-2 country COVID-19 COVID-19 pandemic Critical early stage effective Effectiveness Europe European country FIVE Germany Health highest hygiene identify implementation indicated Infection information Italian Italy less lockdown measure Measures media Netherland Netherlands outbreak pandemic participant Perspective Protective Public reported respondent response responses selective social distancing Social distancing measure Spread stage III submitted Support [DOI] 10.1371/journal.pone.0236917 PMC 바로가기 [Article Type] Research Article
ENDOCRINOLOGY IN THE TIME OF COVID-19: Remodelling diabetes services and emerging innovationClinical Practice Guidance Published on 2020-08-052022-10-31 Journal: European Journal of Endocrinology [Category] COVID-19, MERS, [키워드] accelerated acute COVID-19 Care caused chronic disease communicable complications COVID-19 COVID-19 pandemic death diabete Diabetes Mellitus Follow-up globe Guidance Health highest incidence include International less Local maintain management morbidity and mortality National Non-communicable disease nuances Outpatient pandemic Patient positive presenting Public reduced remote monitoring rising risk Self-management serious complication Support tension while with COVID-19 [DOI] 10.1530/EJE-20-0377 PMC 바로가기 [Article Type] Clinical Practice Guidance
Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial체중이 20kg 이상인 HIV가 있는 소아에 대한 단순 돌루테그라비르 투여: 다기관, 무작위 ODYSSEY 시험의 약동학 및 안전성 하위 연구Article Published on 2020-08-042022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] (coefficient of variation (cryptococcal meningitis Adults adverse event adverse events AIDS approval approved Asymptomatic baseline children coefficient Coefficient of variation Concentration concentration-time curve cryptococcal meningitis dolutegravir dose dosed doses drug enrolled estimate European evaluate evaluated finding follow-up period food foundation funding geometric geometric mean highest HIV less Medical Research Council Meningitis multicentre network neutropenia ODYSSEY once daily Open-label over Patient pharmacokinetic pharmacokinetic data plasma profile randomised reference values regulatory authority reported required Research SRA subject Tablet tablets target the WHO Treatment Trial Uganda Variation was done weighed with HIV Zimbabwe [DOI] 10.1016/S2352-3018(20)30189-2 PMC 바로가기 [Article Type] Article
Predictive Model and Risk Factors for Case Fatality of COVID-19: A Cohort of 21,392 Cases in Hubei, ChinaArticle Published on 2020-08-032022-10-30 Journal: The Innovation [Category] COVID-19, [키워드] 95% CI 95% confidence interval adopted age Analysis body temperature China Clinical symptoms cohort study Combination Comorbidities Comorbidity coronavirus disease COVID-19 COVID-19 case COVID-19 patient COVID-19 patients Cox regression model Critical Critically ill patient death death rate demographic characteristics determinant died elderly Evidence Factor Factors fatality female hazard ratio highest individual Laboratory Lymphocyte count male medical resource Mild Model Older age Patient patients predicted Predictive predictors Probability Public recruited reduce risk factor severity Sex significantly symptom onset the disease White blood cell [DOI] 10.1016/j.xinn.2020.100022 PMC 바로가기 [Article Type] Article
SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers Research Published on 2020-08-022022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] SARS, 진단, [키워드] ACE2 ACE2 expression addition appear Blood cells characteristic chorionic congenital COVID-19 demonstrated Direct endothelial cells Endothelium examined Express expression highest Histopathology immunohistochemistry infect Infection infections many case mother Placenta placental Placental infection placental tissue Pregnancy protein expression required RNA expression SARS-CoV-2 SARS-CoV-2 RNA shown TMPRSS2 TMPRSS2 expression TMPRSS2 protein Transmission viral infection [DOI] 10.1038/s41379-020-0639-4 [Article Type] Research
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies로피나비르에 대한 임신초기 노출(다루나비르 아님)은 탈락막화를 손상시킵니다: HIV 양성 임신에서 출산 결과가 좋지 않을 수 있는 잠재적 기전Article Published on 2020-08-012022-09-11 Journal: Human reproduction (Oxford, England) [Category] Coronavirus, 비임상, [키워드] Activation Administered Affect age alteration Analysis Angiogenesis animal model Antiretroviral therapy approval Biomarker Biomarkers biopsy birth outcomes breath cART cause caution Cell Cell culture cells chance clinical implications clinical trial clinical trials clinically co-culture Combination complement Complement activation conception contributing to correlation COVID-19 COVID-19 pandemic Culture culture system current darunavir decidualization decrease drug candidate Drug safety dysregulation early pregnancies early pregnancy early stage early stages Effects Efficacy ELISA evaluate evaluated event Evidence evidence of Ex vivo experimental models expression Factor Factors female first trimester flow cytometry for inclusion foundation funding gestational age Health care Health care worker health care workers healthy highest highlight HIV HIV infection HIV protease inhibitor HIV protease inhibitors immune cell population immune cell populations immune dysregulation Immunohistochemical analysis immunohistochemistry impair impairment implication in vitro in vivo include Inflammation initiated lack leads Lopinavir Luminex assay Lye matter maturation mechanism media mice Migration modify mouse natural killer Natural killer cells offered once daily outcome outcomes Participation placental placentation potential mechanism pregnancies Pregnancy pregnant women prophylactically protease PROTECT quantified reduced regimen regulate reported reproductive resource Respiratory disease sacrifice Safe selective specific effect specific effects spiral spiral artery spiral artery remodeling STAT3 Stephen Support supported TANK termination of pregnancy therapeutic potential Think tank tissue transcription factor Transgender Treatment Trial trophoblast trophoblasts uterine uterine natural killer cells. Vascular viability was measured was obtained was used water were used with HIV women [DOI] 10.1093/humrep/deaa151 PMC 바로가기 [Article Type] Article