First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in ArgentinaResearch Article Published on 2018-09-242022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] animal Antibiotics Antigen case sery characterized circulating Clinical diagnosis Clinical signs Complete coronavirus criteria detect determine Diagnosis diarrhea distribution Endemic epidemiological etiological evaluated Final gastroenteritis granular histological immunohistochemistry increase in Infection intestine lesion Microscopy monoclonal morbidity Mortality mRNA neonatal diarrhea Neonatal Mortality organization Particle pathogen PEDV Piglets Porcine transmissible gastroenteritis virus Region respond Result Retrospective study serological service Spike protein supplementary material TGEV viral infection virus virus infection was performed watery [DOI] 10.1186/s12917-018-1615-9 PMC 바로가기 [Article Type] Research Article
Oral immunization with a novel attenuated Salmonella Gallinarum encoding infectious bronchitis virus spike protein induces protective immune responses against fowl typhoid and infectious bronchitis in chickens신형 약화된 살모넬라 갈리나룸을 이용한 경구 면역화가 감염성 기관지염 바이러스 스파이크 단백질을 인코딩하여 닭에서 조류 티푸스와 감염성 기관지염에 대한 보호 면역 반응을 유도한다.Research Article Published on 2018-09-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, 살모넬라증, [키워드] Affect Against bronchitis caused Cell-mediated immunity clone cloned control group control groups demonstrated disease elicit elicited exhibited expression vector Fowl group humoral IBV induce Infectious Bronchitis Virus Inflammatory lesion Mortality mutant nucleotide sequence Oral Immunization PBS Plasmid protective immune response protective immunity Protein Salmonella shown significantly Spike protein supplementary material tissue tracheal Vaccine virulent virus wild-type [DOI] 10.1186/s13567-018-0588-9 PMC 바로가기 [Article Type] Research Article
Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalizationResearch Published on 2018-08-302022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 2B11 antibody attachment B cell binding blocked cause Cell conformational defined epidemic diarrhea epitope expression generate host cell receptor identify Infection inhibit inhibited Isolating mAb mechanism monoclonal antibody neutralized neutralizing antibody pathogenic coronavirus PEDV Porcine epidemic diarrhea virus prokaryotic expression system qPCR receptor-binding domains Result S protein secrete specific antibodies suggested supplementary material Surface glycoprotein target protein the receptor-binding domain Vero cells Vero E6 cell viral spike virions virus virus entry virus infection was performed was used were used [DOI] 10.1186/s12985-018-1042-3 PMC 바로가기 [Article Type] Research
Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 20162013년부터 2016년까지 파리 지역에서 중동호흡기증후군 코로나바이러스 감염이 의심되는 환자들의 호흡기 증후군 임상 관리Research Article Published on 2018-07-162022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, 폐렴구균 감염증, [키워드] acute respiratory syndrome Analysis Antibiotics association Bacterial cause Characteristics clinical Confusion died duration of hospitalization effective Hospitalized Infection Infectious disease initiated Isolation Isolation ward Legionella Legionella pneumophila male management median median age MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) neuraminidase inhibitor outcome Paris Patient patients patients hospitalized Pilgrims Plasmodium falciparum malaria respiratory syndrome coronavirus respiratory tract infection Result returned RT-PCR Saudi Arabia Streptococcus pneumoniae supplementary material syndrome time Transmission Treatment Two patient Virological virus X-ray [DOI] 10.1186/s12879-018-3223-5 PMC 바로가기 [Article Type] Research Article
Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cellsResearch Article Published on 2018-07-032022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] absence Betacoronavirus Bovine coronavirus Cell cell line cellular endocytic examined human coronavirus OC43 inhibitor involved marker pathway rectal Respiratory Coronavirus siRNA supplementary material the Coronaviridae tumor cell virus virus entry virus particle [DOI] 10.1186/s13567-018-0551-9 PMC 바로가기 [Article Type] Research Article
Development of pooled testing system for porcine epidemic diarrhoea using real-time fluorescent reverse-transcription loop-mediated isothermal amplification assayResearch Article Published on 2018-05-292022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Active surveillance analysed approach cause costly develop development Diagnosis diarrhoea effective emerging disease Epidemic epidemiological survey fluorescent Genome high mortality identify implementation information isothermal amplification M gene One-step RT-PCR PEDV Pooled stool samples Result reverse transcription RT-LAMP RtF-RT-LAMP supplementary material Support Surveillance time-consuming virus [DOI] 10.1186/s12917-018-1498-9 PMC 바로가기 [Article Type] Research Article
Molecular characterization of US-like and Asian non-S INDEL strains of porcine epidemic diarrhea virus (PEDV) that circulated in Japan during 2013–2016 and PEDVs collected from recurrent outbreaksResearch Article Published on 2018-03-142022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] affected Analysis analyzed ancestor antigenicity Asian caused changes in Characteristics circulating classical collected comparison develop Efficacy Endemic epidemic diarrhea Epidemics epitope full-length Genetic genetic heterogeneity glycosylation help introduced Japan Japanese Local M gene measure membrane Molecular epidemiology N gene North nucleocapsid outbreak Outbreaks parental PEDV phosphorylation sites Porcine epidemic diarrhea virus Proteins provide Region regions responsible Result resulting S gene sequence sequenced spike gene strain Strains subsequent substitutions suggested supplementary material the disease Vaccine vaccine strain virus [DOI] 10.1186/s12917-018-1409-0 PMC 바로가기 [Article Type] Research Article
Oral recombinant Lactobacillus vaccine targeting the intestinal microfold cells and dendritic cells for delivering the core neutralizing epitope of porcine epidemic diarrhea virusResearch Published on 2018-02-092022-10-29 Journal: Microbial Cell Factories [Category] Coronavirus, MERS, [키워드] Administered administration antibody Antigen caused Cell cells Cellular immune response COE cytokine DCs dendritic dendritic cell dendritic cell-targeting peptide epidemic diarrhea epitope evaluated expressed expressing fused genitalis group humoral IL-4 immunization immunized in vitro induce Infection intestinal lactobacillus Lactobacillus casei Ligand ligands mice Microfold cell-targeting peptide mucosal Neutralizing Neutralizing activity oral Oral Immunization PEDV peptide Porcine epidemic diarrhea virus proliferation Result sera significant difference significantly higher specific IgG antibody Spike protein Stool strain supplementary material tractus Vaccine virus [DOI] 10.1186/s12934-018-0861-7 PMC 바로가기 [Article Type] Research
Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in JapanResearch Published on 2018-02-022022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Administered Antibody titer caused Clinical sign conditions control group diarrhea Efficacy epidemic diarrhea evaluated exhibited immune response Immunity Infectious disease Japan lactogenic Lactogenic immunity mortality rate negative control Newborn PEDV Porcine epidemic diarrhea Porcine epidemic diarrhea virus pregnant prevalent reduced Result serum significantly supplementary material survival rate Symptom the vaccine vaccination Vaccine virus Virus neutralization watery [DOI] 10.1186/s12985-018-0940-8 PMC 바로가기 [Article Type] Research
Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trialStudy Protocol Published on 2018-01-302022-10-29 Journal: Trials [Category] Coronavirus, [키워드] adjust Antiviral center clinical trial Combination components coronavirus Coronavirus infection determine double-blind effective Efficacy enrolled Hospital admission in vitro include Interferon-β1b investigated King laboratory-confirmed Lopinavir-ritonavir Lopinavir/ritonavir MERS MERS-CoV Middle East Mortality multicenter Patient Placebo placebo-controlled Potential treatment Primary outcome protocol provided randomized clinical trials Randomized controlled trial respiratory Result Sample size Saudi Arabia specific treatment Standard standard supportive care Study protocol supplementary material Treatment Trial was recorded [DOI] 10.1186/s13063-017-2427-0 PMC 바로가기 [Article Type] Study Protocol