Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physiciansResearch Article Published on 2016-07-122022-10-28 Journal: BMC Anesthesiology [Category] Coronavirus, MERS, [키워드] Blood Care clinical trial convalescent convalescent plasma Convalescent plasma therapy coronavirus Critical care Critically ill determine diagnose domain feasibility high mortality rate ICU ICUs include indicated Infection involved ISARIC Kingdom Laboratory majority MERS-CoV MERS-CoV-infected patient Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) MOST participated patients physician Physicians Placebo questionnaire Randomized controlled trial Randomized controlled trials RCT RCTs recovered patients reported Research respiratory respiratory pathogen responsible Result Saudi Arabia specific treatment supplementary material Treatment while [DOI] 10.1186/s12871-016-0198-x PMC 바로가기 [Article Type] Research Article
Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmissionResearch Published on 2016-06-132022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] analyzed antibodies BCoV BCV biosecurity Blood Clinical signs concerning conducted Contact coronavirus correlated cough Depression detectable disease euthanized experiment Experimental infection fecal group Hypothesis Infection information investigated knowledge lack lymphatic tissue Mild naïve nasal nasal swabs occur pathogen potential for transmission prevention producing Prolonged provide rectal respiratory rate Respiratory system Result RNA RT-qPCR secretion seropositive supplementary material swabs temperature tissue tissue sample transmission potential Viral RNA viral shedding Viremia virus virus isolation Virus quantification Virus shedding virus spread was performed [DOI] 10.1186/s12985-016-0555-x PMC 바로가기 [Article Type] Research
Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patientsResearch Published on 2016-05-072022-11-01 Journal: Critical Care [Category] Coronavirus, MERS, [키워드] Admission age Analysis APACHE II applied bilateral pulmonary infiltrates Clinical data clinical feature coronavirus death Epidemic greater high mortality rate ICU independent risk factor Infection intensive care Invasive mechanical ventilation males mechanical ventilation MERS-CoV MERS-CoV infection Middle East morbidity and mortality observation period Older organ dysfunction outcome Patient patients patients died polymerase chain presentation reported Respiratory failure Respiratory samples respiratory syndrome coronavirus Result reverse transcription risk factor Saudi Arabia severity SOFA score supplementary material syndrome tachypnea therapy Vasopressor [DOI] 10.1186/s13054-016-1303-8 PMC 바로가기 [Article Type] Research
Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in Escherichia coliResearch Article Published on 2016-05-042022-10-27 Journal: BMC Biotechnology [Category] Coronavirus, [키워드] antigens chaperone Chaperone co-expression system cloned co-expression condition contagious develop elicited ELISA epidemic diarrhea Escherichia coli expressed expression expression vectors immune immunization immunogenic Inclusion inclusion bodies mAb mice neutralizing antibody pathogen PEDV produced Protein protein antigen Proteins purified reactivity Recombinant protein recombinant proteins Recombinant spike protein Result S protein sera serum IgG Serum neutralizing antibody spike glycoprotein Strains subunit Subunit vaccine supplementary material tested Trigger Trigger factor Vaccine variety virus western blot [DOI] 10.1186/s12896-016-0268-7 PMC 바로가기 [Article Type] Research Article
Molecular epidemiology and evolutionary histories of human coronavirus OC43 and HKU1 among patients with upper respiratory tract infections in Kuala Lumpur, MalaysiaResearch Published on 2016-02-252022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute respiratory symptom Analysis Asia assigned Bayesian Betacoronavirus Characteristics China circulating circulation clinical symptom Coronaviruses country detection rate distribution Epidemiology evolutionary dynamics Genetic genetic diversity Genotype genotypes genotypic HCoV-HKU1 HCoV-OC43 HKU1 human coronavirus OC43 Infection isolate Japan Lineage lineages location lowest majority Malaysia molecular Molecular epidemiology Multiplex PCR novel lineage nucleocapsid Patient phenotypic Phylogenetic phylogenetics positive Recombination reported respiratory symptom Result screened sequenced severity SIGN specimen spike gene spike glycoprotein strain supplementary material tested TMRCA tropical upper respiratory infection upper respiratory tract Virus evolution [DOI] 10.1186/s12985-016-0488-4 PMC 바로가기 [Article Type] Research
RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrationsResearch Article Published on 2016-01-272022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Activation adaptive Adaptive immune response Analysis bronchitis caused chicken Concentration contagious coronavirus DE gene Differential gene expression differentially expressed disease euthanized expression expression profile Gene ontology Genes GO term IBV IBV infection immune immune response Immunity Immunoglobulin improvement Infection Infectious bronchitis Infectious Bronchitis Virus Interaction involved leukocyte mannose-binding lectin molecular mechanism post infection Process proliferation Recombination Regulation Result RNA RNA sequencing selected serum significant difference spleen subset supplementary material System T cell T cell activation Transcriptome understanding uninfected was performed were infected were used [DOI] 10.1186/s12864-016-2403-1 PMC 바로가기 [Article Type] Research Article
First detection, clinical presentation and phylogenetic characterization of Porcine epidemic diarrhea virus in AustriaCase Report Published on 2015-12-302022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] affecting alphacoronavirus Analysis antibody Asian Austria Case report characterized Complete contagious diseases death described detectable diarrhea disease distribution Effect epidemic diarrhea Europe First case Gastrointestinal generally mild Germany Health in both group introduced involved outbreak pathogenic PEDV Phylogenetic Porcine epidemic diarrhea virus reported RNA RT-qPCR serology serum spike gene Spread strain supplementary material Symptom syndrome the disease USA variant virus watery while [DOI] 10.1186/s12917-015-0624-1 PMC 바로가기 [Article Type] Case Report
Pathosphere.org: pathogen detection and characterization through a web-based, open source informatics platformSoftware Published on 2015-12-292022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, [키워드] addition Analysis analyzed annotation bioinformatics Biological center Chemical Community complex coronavirus creating detect Government homology Host identify Illumina Infectious disease Ion iterative NCBI Next-generation sequencing NGS pathogen pathogen detection platform provide Result sequence sequenced Sequencing supplementary material Support tested the United State utility variety zoonotic [DOI] 10.1186/s12859-015-0840-5 PMC 바로가기 [Article Type] Software
MERS coronavirus: diagnostics, epidemiology and transmissionReview Published on 2015-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, 핵심논문, [키워드] Acute kidney injury acute respiratory distress acute respiratory syndrome appear Arabian Peninsula Cell close contact Comorbidities conditions coronavirus cough CoV death diagnostics disease Epidemiology Evidence Fever growth HCWs healthcare healthcare worker Human human infections humans Infection Infection prevention influenza-like illness Jeddah Jordan kidney Kingdom Laboratory Lower respiratory tract LRT majority male MERS MERS patient MERS-CoV Middle East Middle East respiratory syndrome Mild MOST multiorgan failure Novel coronavirus occurred Patient Pneumonia polymerase chain reported Respiratory failure Saudi Arabia sensitive sequence severe disease supplementary material Symptoms syndrome transcriptase Transmission underlying disease upper respiratory tract virus virus detection while widespread Zoonotic coronavirus [DOI] 10.1186/s12985-015-0439-5 PMC 바로가기 [Article Type] Review
The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birdsResearch Article Published on 2015-10-092022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Affect analysed Bacterial infection biological pathway can be used candidate gene cause chicken contagious coronavirus disease Disease resistance Effect evaluated examined expression functional Gene Expression gene expression differences Genetic Genome help Host host response IBV IBV infection identify immune response Infection Infectious Bronchitis Virus innate immune response involved lesion Microarray Mortality occur Post-infection Potential reproductive resistance gene Respiratory disease responsible Result selective subsequent supplementary material susceptible target the disease tissue tracheal vaccination virus were used [DOI] 10.1186/s12917-015-0575-6 PMC 바로가기 [Article Type] Research Article