Immune activation and induction of memory: lessons learned from controlled human malaria infection with Plasmodium falciparumarticle Published on 2016-02-282024-09-01 Journal: Parasitology [Category] 말라리아, [키워드] Activation Adaptive immune response blood stage controlled human infection immune memory Innate immunity malaria Plasmodium falciparum Regulation sporozoite [Article Type] article
RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrationsResearch Article Published on 2016-01-272022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Activation adaptive Adaptive immune response Analysis bronchitis caused chicken Concentration contagious coronavirus DE gene Differential gene expression differentially expressed disease euthanized expression expression profile Gene ontology Genes GO term IBV IBV infection immune immune response Immunity Immunoglobulin improvement Infection Infectious bronchitis Infectious Bronchitis Virus Interaction involved leukocyte mannose-binding lectin molecular mechanism post infection Process proliferation Recombination Regulation Result RNA RNA sequencing selected serum significant difference spleen subset supplementary material System T cell T cell activation Transcriptome understanding uninfected was performed were infected were used [DOI] 10.1186/s12864-016-2403-1 PMC 바로가기 [Article Type] Research Article
Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patientsResearch Article Published on 2015-03-062023-08-29 Journal: BMC Cancer [Category] E형 간염, [키워드] Adaptive immune response Breast cancer Immune cell infiltration Tertiary lymphoid structures Tumor [DOI] 10.1186/s12885-015-1116-1 PMC 바로가기 [Article Type] Research Article
Cytokine and chemokine profile of the innate and adaptive immune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon가봉 람바레네의 풍토병 지역에서 단일 및 공동 감염된 학령기 아동의 Schistosoma haematobium 및 Plasmodium falciparum의 선천적 및 적응 면역 반응의 사이토카인 및 케모카인 프로필Research Published on 2015-02-252024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Adaptive immune response Co-infection Epidemiology innate immune response Lambaréné malaria principal component analysis Schistosomiasis School-aged children [DOI] 10.1186/s12936-015-0608-4 PMC 바로가기 [Article Type] Research
Coronavirus virulence genes with main focus on SARS-CoV envelope geneArticle Published on 2014-08-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection [DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article
Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus InfectionResearch Article Published on 2014-03-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Adaptive immune response addition Administered airway airways alveolar macrophage CD4 CD4 T cell CD8 T cell coronavirus Coronavirus infection Critical Depletion disease evaluated Frequency Hepatitis Human Infection Liposome lung lung tissue mice Mild modulating morbidity and mortality mouse Pathogenesis pulmonary Respiratory disease shown significant increase subsequent susceptible Treg virus [DOI] 10.1371/journal.pone.0090720 PMC 바로가기 [Article Type] Research Article
Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?Research Article Published on 2014-02-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence adaptive Adaptive immune response Antigen presentation Antiviral approach BAL Bench Can Cell chemokine compared Consensus control patients coronavirus Critical cytokine decrease determine died different dsRNA early stage enzyme-linked immunosorbent highlight humans IFN IFNα IFNγ IL-12 IL-17 immune response impair in vitro Infected infected patient Infection initial intensive care involved mechanism MERS-CoV MERS-CoV infection Middle East National Occurrence outcome Patient polymerase chain promote respiratory response RNA robust secretion sera supernatant therapeutic approaches Treatment viral dsRNA viruses was performed were used World Health Organization [DOI] 10.1371/journal.pone.0088716 PMC 바로가기 [Article Type] Research Article
Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rashArticle Published on 2012-03-082023-05-31 Journal: Journal of Neurovirology [Category] Fulltext, 두창, 수두, 홍역, [키워드] Adaptive immune response ganglia latency rhesus macaques Simian varicella virus Viremia [DOI] 10.1007/s13365-012-0083-4 PMC 바로가기 [Article Type] Article
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
Human immunopathogenesis of severe acute respiratory syndrome (SARS)Article Published on 2007-03-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Adaptive immune response cellular chemokine Clinical course Complete complex cytokine dysregulated hallmark Host host immune system host immunity host response Human human host hypercytokinemia IFN Immunity immunological Immunopathogenesis immunopathology Impact imperative Infected infectious Inflammatory response Injury Innate immunity interferon mechanism Microarray molecular morbidity Progressive Protective Research response resulting SARS SARS Coronavirus SARS CoV SARS patients severe pathology severe SARS suggested systematic analysis type I [DOI] 10.1016/j.virusres.2007.02.014 PMC 바로가기 [Article Type] Article