The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signalinglncRNA Snhg1-Vps13D 소포 트래피킹 시스템은 IL-7 신호 전달의 이중 효과 조절을 통해 메모리 CD8 T 세포 확립을 촉진합니다Article Published on 2021-03-242022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] acute viral infection Adaptive immunity Blimp1 CD8 CD8 T cell CD8 T cells Cell Cell Biology conserved convalescent COVID-19 patients differentiation Effect expression expression pattern Human IL-7 IL7R indicated Infection lncRNA mechanism membrane memory memory formation mice Non-coding RNAs pandemic pathogen pathogen-specific PBMC performed persistence promote Protein recent regulated Reinfection RNA Signaling Snhg1 STAT3 subset survival T cell T cells TCF7 transcriptional vaccination Vesicle viral infection Vps13D [DOI] 10.1038/s41392-021-00492-9 PMC 바로가기 [Article Type] Article
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2동반 질환은 SARS-CoV-2에 대한 적응 면역 반응의 변화와 관련이 있습니다.Research Article Published on 2021-03-222022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료법, [키워드] Adaptive immune response Adaptive immunity age Analysis antibody Antibody Response Antibody responses Beta cells breadth CD4 Clinical outcome Cohort Comorbidities convalescent COVID-19 death diabetes envelope protein envelope proteins Ethnicity flow cytometry function functional functions Hospitalization Hospitalized illness illnesses immune system immunology magnitude nucleocapsid obesity reduced risk factor S1 domain SARS-CoV-2 serology severe COVID-19 Sex subject subjects symptom onset T cell T cells These data [DOI] 10.1172/jci.insight.146242 PMC 바로가기 [Article Type] Research Article
Adaptive immunity to human coronaviruses is widespread but low in magnitudeOriginal Article Published on 2021-03-172022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] Adaptive immunity Adults anatomical antibody Antibody Response Antigen Blood Ccr6 CD4 T cell CD4 T cells CD4 T‐cell Cell cellular central memory Chemokine receptor childhood circulating circulation component coronavirus coronavirus immunity correlated Critical cTFH CXCR3 Endemic exhibited expression follicular Frequency HCoV HCoVs HKU1 homeostatic human coronavirus humoral IgG immune response include individuals Lymph node lymph nodes magnitude marker memory memory T cell Mortality objective participant phenotype phenotypic provide quantified response responses Result SARS‐CoV‐2 SARS‐CoV‐2 Seroconversion T cell T‐cell T‐cell response titres widespread [DOI] 10.1002/cti2.1264 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals코로나19 감염자의 B세포 에피토프 분석을 통한 SARS-CoV-2 유도 체액성 면역Article Published on 2021-03-152022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료제, [키워드] adaptive Adaptive immunity Analysis antibody production Antibody titer B cell B cell epitope B cell epitopes city coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infected individual COVID-19 patient COVID-19 patients domain elevated ELISA epitope Epitopes hot spots Humoral immunity IgG IgM Immunity immunology individual Individual differences Infection intensive care intensive care unit linear linear B MOST N-terminal domain Neutralizing activity Neutralizing antibody titer Patient patients predicted pseudotype pseudotype virus RBD Receptor-binding domain S protein SARS-CoV-2 serum spike glycoprotein the S protein the vaccine university Vaccine development virus-neutralizing [DOI] 10.1038/s41598-021-85202-9 PMC 바로가기 [Article Type] Article
The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity질병 중증도가 다른 COVID-19 환자의 이분성 및 불완전 적응 면역Clinical Trial Published on 2021-03-082022-08-13 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 비임상, 임상, [키워드] 10 asymptomatic patient 10 asymptomatic patients acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Asymptomatic asymptomatic or mild symptomatic patients asymptomatic patient asymptomatic patients B cell response B cell responses breath caused CD8 Cell Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccines CXCL13 disease severity effective follicular GC response indicator GC response indicators Germinal center humoral Humoral immunity immune responses Immunity induce mechanism memory B memory B cell Mild moderate moderate or severe disease mounted Patient patients PROTECT protective immunity respiratory response robust SARS-CoV-2 SARS-CoV-2 antibody responses SARS-CoV-2-specific B-cell serum CXCL13 severe acute respiratory syndrome Coronavirus severe disease symptomatic patient T cell T cell responses T cells T-cell Response T-cell responses [DOI] 10.1038/s41392-021-00525-3 PMC 바로가기 [Article Type] Clinical Trial
Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitroLetter Published on 2021-03-022022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] Coronavirus, Fulltext, SARS, [키워드] Adaptive immunity Chemokine receptor Immunological disorders in vitro inhibitor lymphocyte patients with COVID-19 Transmission [DOI] 10.1038/s41392-021-00516-4 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiencyX-연관 중증 복합 면역결핍증이 있는 유아의 간염과 관련된 SARS-CoV-2 감염Case Reports Published on 2021-03-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 치료기술, [키워드] adaptive Adaptive immunity Allogeneic Antigen B cells caused CD34 Cell clinically combined immunodeficiency Conditioning convalescent plasma COVID-19 deficiencies deficiency disorder Donor dysfunction Gene therapy Hepatitis IL-2 receptor Immunity immunodeficiency Inborn error inborn errors of immunity Infant infected with SARS-CoV-2 Mutation Nasopharyngeal swab nasopharyngeal swabs Natural killer cells NK cells opportunistic Infections Patient respiratory respiratory symptom respiratory symptoms resulting RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 specific antibodies SCID selected severe combined immunodeficiency specific antibodies stem cell Transplant transplantation treated X-linked [DOI] 10.1016/j.clim.2020.108662 PMC 바로가기 [Article Type] Case Reports
Interrogation of the cellular immunome of cancer patients with regard to the COVID-19 pandemic코로나19 팬데믹에 대한 암 환자의 세포 면역 체계 조사Review Published on 2021-03-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] SARS, 바이오마커, [키워드] adaptive Adaptive immunity addition adverse event age Antiviral agents Autoimmune cancer patient Cancer patients Cell cellular complexity COVID-19 COVID-19 pandemic Cytokines detect determined by Effectiveness Factor Factors healthy donor healthy donors help Host Immune cell immune cells Immunity Immunotherapy infected cells Infection Lymphocytes management Pathogenesis pathogenesis of SARS-CoV-2 periphery receiving SARS-CoV-2 infections SARS-CoV-2 spike protein Severity of infection Spike protein steroid Steroids subset T-lymphocytes the SARS-CoV-2 Vaccine virus-infected cells while [DOI] 10.1136/jitc-2020-002087 PMC 바로가기 [Article Type] Review
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunityarticle Published on 2021-03-012024-09-02 Journal: The Journal of Clinical Investigation [Category] 대상포진, [키워드] Adaptive immunity Beta cells immunology Influenza Vaccines [DOI] 10.1172/JCI140794 PMC 바로가기 [Article Type] article
Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19심각한 COVID-19 생존자의 첫 번째 물결에서 항혈청의 효과적인 바이러스 중화 활동Research Article Published on 2021-02-222022-09-10 Journal: JCI Insight [Category] MERS, 진단, 치료법, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Antibody Response Antibody responses Antisera caused collected convalescent phase coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 cases declined First wave Health crisis humoral immune response identify IgG IgG level IgG levels immunoglobulins knowledge Longevity magnitude Neutralizing antibodies neutralizing antibody nucleocapsid protein pandemic Patient patients with COVID-19 performed public health crisis RBD Receptor binding domain respiratory SARS-CoV-2 serological serum severe acute respiratory syndrome Coronavirus severe COVID-19 specimen survivor Vaccines virus-neutralizing Wuhan Wuhan, China [DOI] 10.1172/jci.insight.146267 PMC 바로가기 [Article Type] Research Article