ECMO 11-day-offline treatment of COVID-19-induced acute respiratory distress syndrome: A case report and a single-center experienceCorrespondence Published on 2022-03-012022-10-05 Journal: Asian journal of surgery [Category] SARS, 치료법, [키워드] acute respiratory distress ARDS Case report COVID-19 CT ECMO single-center Treatment [DOI] 10.1016/j.asjsur.2021.12.063 [Article Type] Correspondence
Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled TrialClinical Trial Published on 2022-03-012022-10-05 Journal: Chest [Category] SARS, 임상, [키워드] activated alteplase ARDS baseline benefit bleeding event Brain Combination control group Controlled COVID-19 cross-sectional early administration eight Enrollment failure fibrinolysis Hemorrhagic IMPROVE Improvements improvements in oxygenation in-hospital mortality IQR maintain mechanism microthrombi Mortality neurologic observation occurred outcome Participants Patient patients Phase 1 Phase 2 phase 3 study Primary outcome pulmonary pulmonary failure Pulmonary function randomization Randomized receiving respiratory Respiratory failure Safe SARS-CoV-2 secondary severe COVID-19 significantly Standard-of-care statistically significant difference stroke therapeutic tissue plasminogen activator Tissue plasminogen activator (tPA) Treatment Vascular ventilator-free day VFD were excluded [DOI] 10.1016/j.chest.2021.09.024 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 Cardiovascular Connection: A Review of Cardiac Manifestations in COVID-19 Infection and Treatment ModalitiesReview article Published on 2022-03-012022-10-05 Journal: Current problems in cardiology [Category] 치료법, [키워드] acute respiratory distress addition affected ARDS Asymptomatic cardiac cardiac complication Cardiac complications Cardiomyopathy cardiovascular clinical manifestation component condition coronavirus COVID-19 COVID-19 infection death effort fibrosis Healthcare system Inflammatory response Injury life-threatening manifestation modality morbidity and mortality Myocardial myocardial injury myocarditis outbreak pandemic Patient positive presenting Prevent preventative measure review robust severe pneumonia shown Symptom syndrome thrombosis Treatment vaccination virus with COVID-19 [DOI] 10.1016/j.cpcardiol.2022.101186 [Article Type] Review article
COVID-19 acute respiratory distress syndrome: A simulation study of the effects of combination therapy with tocilizumab and siltuximabCOVID-19 급성 호흡곤란 증후군: 토실리주맙과 실툭시맙 병용 요법의 효과에 대한 시뮬레이션 연구Article Published on 2022-03-012022-09-12 Journal: British Journal of Clinical Pharmacology [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS binding binding constant blockade Bronchoalveolar lavage fluid combination therapy complex component Concentration COVID-19 COVID-19 patient develop Effect generate greater IL-6 IL-6 antagonist IL-6 level IL-6 receptor IL-6R interleukin-6 Intervention literature lung Model modelling monotherapy normal predict predicted reduced reduction reflect risk SARS-COV-2 infection sequestering sIL-6R siltuximab Simulation subject subjects syndrome targets TCZ Tocilizumab treat Treatment were used [DOI] 10.1111/bcp.15009 PMC 바로가기 [Article Type] Article
A computational and bioinformatic analysis of ACE2: an elucidation of its dual role in COVID-19 pathology and finding its associated partners as potential therapeutic targetsACE2의 컴퓨터 및 생물정보학 분석: COVID-19 병리학에서 ACE2의 이중 역할에 대한 설명 및 잠재적인 치료 표적으로서 관련 파트너 찾기Article Published on 2022-03-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting acute respiratory distress acute respiratory distress syndrome Acute respiratory distress syndrome Predicted ACE2 structure Analysis analyzed angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme -2 angiotensin-converting enzyme 2 ARDS bioinformatic analysis CDS Cell coding COVID-19 pandemic COVID-19 pathology determine Differentially expressed genes disease distress DNA sequence downregulation effort enzyme FOS FOXO4 FOXP2 healthy human lung tissue involved list low expression mechanism MiR-212-5p miRNA miRNA target miRNA targets miRNA-1246. pandemic pathological changes potential therapeutic target provide receptor respiratory distress Respiratory distress syndrome Spike protein Spread syndrome transcription factor transcription factors upregulation Vaccine viral entry viral spike protein [DOI] 10.1080/07391102.2020.1833760 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology featuresCOVID-19 치료용 면역조절제: 가능한 작용 기전 및 면역병리학적 특징Review Published on 2022-03-012022-09-11 Journal: Molecular and cellular biochemistry [Category] MERS, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme Anosmia antagonists applied ARDS blood vessel body aches cause clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 case COVID-19 patient COVID-19 patients COVID-19 treatment Critical critical patients cytokine Cytokine storm Cytokines demonstrated described drug drugs dry cough Endothelial cell endothelial cells excessive secretion feature Fever Health Organization immune system immunomodulatory immunopathology immunosuppressive agent Immunosuppressive agents incidence include Infection Inflammatory responses interleukin investigated lead Lungs mAbs mechanical ventilator mechanism mechanism of action medication membrane mitigate modulating monoclonal antibodies monoclonal antibody mortality rates new virus Novel coronavirus overproduction oxygen Oxygen therapy pandemic pathophysiology Patient patients penetrate Physicians pro-inflammatory factors receptor reduce mortality researchers respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway signaling pathways stimulate Support Symptom syndrome the disease therapeutic compound treat triggering virus World Health Organization Wuhan Wuhan, China [DOI] 10.1007/s11010-021-04325-9 PMC 바로가기 [Article Type] Review
Tocilizumab treatment in severe COVID-19: a multicenter retrospective study with matched controls중증 COVID-19에서의 토실리주맙 치료: 대조 대조군을 사용한 다기관 후향적 연구Multicenter Study Published on 2022-03-012022-09-11 Journal: Rheumatology International [Category] 진단, 치료제, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Analysis anti-IL-6R approach ARDS Arm ARMS carried case-control study collected Control coronavirus coronavirus disease COVID-19 criteria Critical cytokine Cytokine storm death develop distress effective Efficacy evaluate feature ferritin Gender hospitalized COVID-19 patients IL-6 in some interleukin interleukin-6 Interleukin-6 (IL-6) intubation logistic regression models Macrophage macrophage activation syndrome multicenter Multiple no significant difference outcome parameters Patient patients Pneumonia Primary outcome procalcitonin progression provided reduced reduction in Regression model reported respiratory distress Respiratory distress syndrome retrospective retrospective cohort Retrospective study SAS severe disease shown significantly Standard of care study population subset syndrome Tocilizumab Treatment was reduced was used [DOI] 10.1007/s00296-021-04965-6 PMC 바로가기 [Article Type] Multicenter Study
Mesenchymal stem cells and their derived exosomes to combat Covid-19Review Published on 2022-03-012022-10-06 Journal: Reviews in Medical Virology [Category] SARS, 진단, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome ALI Antiviral ARDS carcinogenic Cell clinical trials Complication coronavirus coronavirus disease COVID-19 Cytokine storm evaluated Exosome Exosomes IMPROVE investigated majority mechanism of action mesenchymal stem cell MSC MSCs pandemic paracrine Patient required risk SARS-CoV-2 Stage storage conditions syndrome the disease therapeutic agents therapy Treatment unique [DOI] 10.1002/rmv.2281 PMC 바로가기 [Article Type] Review
A Successful Outcome of Veno-Venous Extracorporeal Membrane Oxygenation in Obese Patients with Respiratory Failure in the Course of COVID-19: A Report of Two CasesCase Report Published on 2022-02-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] acute respiratory distress ARDS BMI condition Course COVID-19 discharged ECMO ECMO therapy Efficacy Extracorporeal extracorporeal membrane oxygenation failure high mortality implementation indicate intensive care life obese patient obese patients organization outcome PaO Patient patients persistence Pneumonia positive Rapid report respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe respiratory failure syndrome use of ECMO were used with COVID-19 [DOI] 10.3390/ijerph19052761 PMC 바로가기 [Article Type] Case Report