Clinical studies – Page 25 – Communicable Diseases Research

Randomised phase II study to optimise melphalan, prednisolone, and bortezomib in untreated multiple myeloma (JCOG1105)

Haematological Malignancy ‐ Clinical

Published on 2020-06-242024-09-04
Journal: British Journal of Haematology [Category] 대상포진,

The effects of blood group types on the risk of COVID-19 infection and its clinical outcome

혈액형이 COVID-19 감염 위험과 임상 결과에 미치는 영향

Article

Published on 2020-06-232022-09-10
Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료기술,

[키워드] Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 advanced age analyzed Bank Blood Blood Bank Blood Group Blood groups caused chronic disease Chronic diseases Clinical outcome clinical outcomes Clinical studies clinical study Comorbidities Control control group controls coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 infection COVID-19 patients diagnosis of COVID-19 disease disease outbreak Effect followed by Frequency groups healthy individuals infected with COVID-19 Infection Infectious disease infectious disease outbreak intensive care intensive care unit intubation material mortalities Mortality not affect outcome pandemic Patient PCR Protective respiratory Respiratory failure Result risk risk of COVID-19 risk of infection SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex shown significantly lower significantly more Spread statistically susceptibility the patient the SARS-CoV-2 university
[DOI] 10.3906/sag-2005-395 PMC 바로가기 [Article Type] Article

Virtual drug repurposing study against SARS-CoV-2 TMPRSS2 target

Article

Published on 2020-06-212022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

CORDITE: The Curated CORona Drug InTERactions Database for SARS-CoV-2

Research article

Published on 2020-06-202022-10-05
Journal: iScience [Category] 신약개발,

[키워드] accelerate API approach bioinformatics Biological Database Clinical studies clinically Clinicians de novo domain drug drug design drugs effective effective drug humans knowledge Medicine Meta-analysis outbreak provide Research researcher SARS-CoV-2 Side effects tested the SARS-CoV-2 virus treatment for COVID-19 Virology
[DOI] 10.1016/j.isci.2020.101297 [Article Type] Research article

Clinical characteristics of Coronavirus Disease 2019 patients in Beijing, China

중국 베이징의 코로나 바이러스 질병 2019 환자의 임상 특성

Research Article

Published on 2020-06-172022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] addition affected age albumin anorexia average average age Beijing C-reactive protein Characteristics China clearance rate clinical clinical feature Clinical studies clinical study Confusion coronavirus coronavirus disease country COVID-19 creatinine creatinine clearance expectoration high systolic blood pressure hospital ICU incidence lymphocyte Lymphocytes median Myoglobin neutrophil Neutrophils Older older patient older patients outbreak oxygen oxygen saturation Patient patients patients died patients with COVID-19 Region retrospective cohort study severe severe disease Severe patient severe patients Shortness of breath significantly significantly increased significantly lower Systolic blood pressure the disease the patient troponin I Wuhan
[DOI] 10.1371/journal.pone.0234764 PMC 바로가기 [Article Type] Research Article

A Pharmacovigilance Study of Hydroxychloroquine Cardiac Safety Profile: Potential Implication in COVID-19 Mitigation

Article

Published on 2020-06-152022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] 95% confidence interval adverse event Adverse reaction AEs Analysis analyzed Arrhythmias Atrioventricular block authorization calculate cardiac cardiac dysfunction Cardiomyopathy cardiovascular adverse events clinical benefits Clinical studies clinical study clinical trial Complete coronavirus disease COVID-19 database dataset determine diastolic drug dysfunction Effectiveness Efficacy Ejection fraction Emergency EUA FDA feasible food HCQ High dose higher risk highlight Hospitalized Hydroxychloroquine investigated Mitigation non-randomized Odds ratio outcome Patient patients performed pharmacovigilance pharmacovigilance analysis Potential predict QT prolongation Randomized Reactions receiving reported robust Safety subsequent therapy torsades de pointe torsades de pointes treatment regimen ventricular was used widespread with COVID-19
[DOI] 10.3390/jcm9061867 PMC 바로가기 [Article Type] Article

A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave?

Commentary

Published on 2020-06-112022-10-29
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] Coronavirus, SARS,

The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 24 hours acid Administered Affect analyst Anti-viral anticipated Beijing block block randomization Blood Body Capital cardiovascular system Care center changed Chinese clinical clinical manifestation Clinical outcome Clinical studies clinical trial college Complete condition Consent control group Corona Corona virus cough COVID-19 criteria curative Diagnosis discharge discharged disease Diseases dissemination dose drug Ebola virus element eligibility criteria enrolled expected experimental group Favipiravir female Follow-up form hepatology history hospital include Including Infection Infectious disease Informed inhibit investigators kidney lack lactating women life-threatening liver Loss male Measures mechanism Medicine Mental Disorders Nasopharyngeal swab nasopharyngeal swabs not blinded nucleic acid nucleic acid test number objective open label oral administration outcome outcome assessors Oxygen therapy parallel group participant Participants Patient plan poor compliance positive protocol Public pulmonary randomised randomised controlled trial randomization system Randomized controlled trial Randomly recruited recruitment reduced Regular Reinfection Research researcher respiratory specimen response returned RNA-dependent RNA polymerase routine screening visit second secondary severe adverse events severity severity of symptoms Shenzhen specimens sputum status Study protocol subject Symptom Symptoms System temperature Test tested therapeutic efficacy throat swabs Traditional Treatment treatment for COVID-19 treatment group Trial uncontrolled university variety viral nucleic acid virus Web website Withdrawal Wuhan
[DOI] 10.1186/s13063-020-04430-y PMC 바로가기 [Article Type] Letter

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

코로나19 환자를 위한 지방유래 중간엽줄기세포의 임상적 사용 근거

Review

Published on 2020-05-182022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 비임상,

[키워드] acute respiratory distress acute respiratory distress syndrome administration alveolar fluid clearance animal model animal models antimicrobial ARDS ASC benefit breath capital city Cell China Clinical studies clinical study Clinical use Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 outbreak COVID-19 patient Critical demonstrated distress edema effective Ex vivo Fever global pandemic globe greater Health Organization healthcare high mortality rate hospital resources human clinical trials human lung hypoxia illness immune response immune responses immunomodulatory activities in some in vivo Inflammation inhibit intravenous Intravenous administration intravenous route lead Local lung lung damage Lungs majority Mesenchymal stem cells molecules morbidity morbidity and mortality MSC MSCs multi-organ failure Multiple Novel coronavirus older patients Pain Patient patient mortality per day Pneumonia pulmonary disease Pulmonary edema Pulmonary function rationale reduce reduced respiratory respiratory distress respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection severe disease Severe respiratory distress stem cell stem cells syndrome therapeutic option therapy Travel Treatment treatment of COVID-19 Viral viral outbreak viral respiratory with COVID-19 World Health Organization Wuhan
[DOI] 10.1186/s12967-020-02380-2 PMC 바로가기 [Article Type] Review

A snapshot of the ongoing clinical research on COVID-19

Brief Report

Published on 2020-05-182022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,