Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy프로테아제 억제제 단독 요법의 PIVOT 시험에서 HIV-1 프로테아제의 차세대 시퀀싱Article Published on 2018-04-012022-09-06 Journal: Journal of Clinical Virology [Category] Communicable Disease, [키워드] Algorithm Antiretroviral therapy clinically Combination combination therapy Coverage described drug drug susceptibility Evidence examined frequencies Frequency frozen plasma Highlights HIV HIV-1 Laboratory leads Local low frequency median time Median viral load methodology monotherapy Mutation mutations next generation sequencing NGS objective Patient patients performed phenotypic plasma sample predict predicted Primary outcome protease Protease inhibitor Public Health England randomisation randomised reported resistance Result Ritonavir Sanger sequencing selected Sequencing Stanford Study design study drug suppressed susceptibility tested the median threshold Trial variant Viral Viral load was performed [DOI] 10.1016/j.jcv.2018.02.003 PMC 바로가기 [Article Type] Article
Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation살모넬라가 P-글리코프로테인 하향 조절을 통해 종양에서 약물 저항성을 극복하다Article Published on 2018-03-092024-08-22 Journal: International Journal of Medical Sciences [Category] 살모넬라증, [키워드] 5-Fluorouracil combination therapy P-glycoprotein Salmonella Tumor
Nicotine Augments the Beneficial Effects of Mesenchymal Stem Cell-based Therapy in Rat Model of Multiple Sclerosisarticle Published on 2018-02-282024-09-01 Journal: Immunological Investigations [Category] 백일해, [키워드] combination therapy experimental autoimmune encephalomyelitis Mesenchymal stem cells multiple sclerosis Nicotine [Article Type] article
Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trialHIV의 2차 치료를 위한 로피나비르 + 뉴클레오시드 역전사효소 억제제, 로피나비르 + 랄테그라비르 또는 로피나비르 단독요법(EARNEST): 무작위 대조 시험의 144주 추적 결과Article Published on 2018-01-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] adverse event African AID analysed Analysis Antiretroviral therapy ART assigned best clinical Combination combination therapy completion computer-generated cooperation country criteria Developing development Efficacy eligibility European event finding FIVE Follow-up funding GRADE grade 3 group HIV-infected people inferiority inhibitor inhibitors intervention group ISRCTN Kenya less limit Lopinavir Medical Research Council Modification monotherapy no difference non-inferiority non-inferiority margin nucleoside offer offered outcome participant partnership Patient per day primary analysis Primary outcome protease Protease inhibitor raltegravir randomisation randomised controlled trial Randomly receive recent regimen regimens Registered Ritonavir screened sequence Serious Adverse Events Swedish Treatment treatment of HIV Trial two-sided α Uganda Viral Viral load viral loads Virological WHO WHO criteria WHO guideline Zimbabwe [DOI] 10.1016/S1473-3099(17)30630-8 PMC 바로가기 [Article Type] Article
Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) systemArticle Published on 2018-01-012023-06-23 Journal: European journal of pharmaceutical sciences : offi [Category] 신종인플루엔자, [키워드] combination therapy Hollow fiber infection model system Pharmacodynamics pharmacokinetics [DOI] 10.1016/j.ejps.2017.10.027 PMC 바로가기
Resource limitation prevents the emergence of drug resistance by intensifying within-host competitionArticle Published on 2017-12-262024-08-27 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] combination therapy competition drug resistance evolutionary management. Plasmodium chabaudi
Toward a Cure for Hepatitis B Virus Infection: Combination Therapy Involving Viral Suppression and Immune Modulation and Long-term OutcomeArticle Published on 2017-11-162023-06-18 Journal: The Journal of Infectious Diseases [Category] B형 간염, [키워드] CHB combination therapy functional cure HBV NA Pegylated interferon [DOI] 10.1093/infdis/jix355
Efficacy and safety of three adefovir-based combination therapies in HBeAg-positive chronic hepatitis B patients with suboptimal response to adefovir monotherapyArticle Published on 2017-11-012023-06-18 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Adefovir combination therapy entecavir lamivudine Suboptimal response telbivudine [DOI] 10.1111/jvh.12792
Addition of nucleoside analogues to peg-IFNα-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNα-2a: a randomized controlled trialResearch Article Published on 2017-08-302023-05-23 Journal: BMC Gastroenterology [Category] B형 간염, Fulltext, [키워드] Chronic Hepatitis B combination therapy interferon nucleoside analog virological response [DOI] 10.1186/s12876-017-0657-y PMC 바로가기 [Article Type] Research Article
Assessment of Clinical Pharmacokinetic Drug-Drug Interaction of Antimalarial Drugs α/β-Arteether and Sulfadoxine-PyrimethamineArticle Published on 2017-08-242024-08-27 Journal: Med Instrum [Category] 말라리아, [키워드] combination therapy malaria pharmacokinetics pyrimethamine sulfadoxine α/β-arteether.