Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21Randomized Controlled Trial Published on 2022-08-152022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] Admission breathlessness cause chest pain Contact Controlled clinical trial COVID COVID-19 COVID-19 infection diagnosis of COVID-19 discharged Dyspnoea early treatment Effect Ethical approval ethics committee Exercise capacity fatigue frailty group Health Health status healthcare professionals hospital hospitalisation hospitalised Infection Intervention Long Long COVID National Health Service NHS participant Patient personalised physical physical activity Pragmatic prevention Primary outcome problem Quality of life questionnaire randomisation randomised randomised controlled trial REC recruitment Registered rehabilitation resistance resistance exercise SARS-CoV-2 secondary outcome spirometry Symptom syndrome therapy Two-arm usual care West [DOI] 10.1186/s13063-022-06632-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Competing Responses to Global Inequalities in Access to COVID Vaccines: Vaccine Diplomacy and Vaccine Charity Versus Vaccine LibertyCOVID 백신에 대한 접근의 글로벌 불평등에 대한 경쟁적인 대응: 백신 외교 및 백신 자선 단체 대 백신 자유Review Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 변종, [키워드] access agency alternatives Antidote coronavirus vaccine Coronavirus vaccines country COVAX COVID Critical Donor dose doses Effectiveness Evolution Government Health immunize include inequality intellectual property International liberty organized overcome promise provide response seeking Social Justice structural violence Structure the vaccine transfer vaccination Vaccine vaccine apartheid vaccine charity vaccine diplomacy vaccine liberty. viral variant Viral variants [DOI] 10.1093/cid/ciac361 PMC 바로가기 [Article Type] Review
To manage long COVID by selective SARS-CoV-2 infection biosensingEditorial Published on 2022-08-112022-10-05 Journal: The Innovation [Category] 변종, [키워드] biosensor COVID Long COVID personalized COVID-19 management point-of-care systems SARS-COV-2 infection selective [DOI] 10.1016/j.xinn.2022.100303 [Article Type] Editorial
Developing a Long COVID Phenotype for Postacute COVID-19 in a National Primary Care Sentinel Cohort: Observational Retrospective Database AnalysisObservational Study Published on 2022-08-112022-10-04 Journal: JMIR Public Health and Surveillance [Category] 임상, [키워드] 95% CI acute COVID-19 acute infection addition biomedical ontologies BioPortal Clinical characteristics clinical symptom clinically coded coding college Comorbidities complex computerized contribute COVID COVID-19 data accuracy data extracts data sets database develop Developing diagnosed Diagnosis Digital tool disease disease management Electronic health record English Epidemiology Ethnicity general practitioner General practitioners groups had no Health Hospital admission Hospitalization Hospitalized include individual Infection Laboratory Logistic regression Long Long COVID long-COVID management medical record systems nomenclature office ontological Ontology Oxford Patient phenotype postacute COVID-19 syndrome primary care problems public health RCGP recorded recruited Research retrospective RSC SARS-CoV-2 sentinel social class Sociodemographic Study protocol Surveillance Symptom Systematized Nomenclature of Medicine used data Validity [DOI] 10.2196/36989 PMC 바로가기 [Article Type] Observational Study
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Case report: SARS-CoV-2 infection as a trigger for diabetic ketoacidosis and newly detected pancreatic autoantibodiesArticle Published on 2022-08-102022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Altered mental status antibody autoantibodies autoantibody autoimminity beta-hydroxybutyrate blood glucose collected coronavirus CoV COVID COVID – 19 diabete Diabetes Mellitus Diabetic diagnosed Diagnosis discharged home Follow-up increased risk Infection infection with SARS-CoV-2 insulin nausea pancreatic past medical history positive regimen SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection Shortness of breath T1D type 1 diabetes (T1D). type 2 diabete vomiting [DOI] 10.3389/fendo.2022.983206 PMC 바로가기
The effect of needle length and skin to deltoid muscle distance in adults receiving an mRNA COVID-19 vaccinemRNA COVID-19 백신을 접종받는 성인에서 바늘 길이와 피부에서 삼각근까지의 거리가 미치는 영향Observational Study Published on 2022-08-052022-09-12 Journal: Vaccine [Category] MERS, 임상, 진단, [키워드] administration Adults age antibody Antibody Response Antibody titre Blood blood sample BMI body mass index collected comparable COVID COVID-19 COVID-19 vaccine Deltoid muscle dose eligible adult Finger prick Follow-up group groups identify immunisation injection intramuscular Intramuscular injection mRNA mRNA vaccines needle Needle length no significant difference participant Participants Primary outcome proportion receiving required sensitivity specificity vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.06.070 PMC 바로가기 [Article Type] Observational Study
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19Research article Published on 2022-08-052022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 BAL BAL fluid bind Biomarker Bronchoalveolar lavage Bronchoalveolar lavage fluid Coagulation system complexes contribute coronavirus COVID COVID-19 Critical dysregulation explain extracellular traps finding funding help hydrolytic activity Hypothesis increased vascular permeability inflammatory chemokines kallikrein-kinin Kallikrein-kinin system Kallikreins Kinins Leuven mechanically ventilated mechanically ventilated patient median myeloperoxidase NETs Neutrophil extracellular trap observation occur oedema Patient patients without COVID-19 peptide peptides plasma potential treatment option receptor Research SARS-CoV-2 severe COVID-19 severe pulmonary disease Support thromboembolic complication thromboembolic complications Thromboinflammation tissue [DOI] 10.1016/j.ebiom.2022.104195 [Article Type] Research article
COVID monoclonal antibody therapy detected by serum immunofixation electrophoresis혈청 면역고정 전기영동으로 검출한 코로나19 단일클론항체 치료Article Published on 2022-08-042022-09-12 Journal: Blood [Category] 진단, [키워드] COVID monoclonal antibody serum therapy [DOI] 10.1182/blood.2022016877 PMC 바로가기 [Article Type] Article
Factors that predict severity of infection and seroconversion in immunocompromised children and adolescents with COVID-19 infectionCOVID-19 감염으로 면역저하된 소아 및 청소년에서 감염 및 혈청전환의 중증도를 예측하는 요인Observational Study Published on 2022-08-032022-09-12 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, [키워드] Absolute lymphocyte count absolute neutrophil count Analysis ANC anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Antibody Response blood sample body mass index Cancer Cell Chemotherapy children Clinical severity comorbid condition COVID COVID 19 COVID-19 infection Critical Cutoff defined determine died Factor FIVE Hematologic malignancy Hematological malignancy high-risk population Hospitalized ICU Immunocompromised Immunocompromised patient immunosuppressive Infection Laboratory less Level lowest median moderate multivariable model observation outcome outcomes Patient patients PCR Pediatric patient predict Predictive receiving required Respiratory Support SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seroconversion seroconversion rate severity Severity of infection stem cell transplant steroid the patient therapy treated univariable vaccination variable was used with COVID-19 [DOI] 10.3389/fimmu.2022.919762 PMC 바로가기 [Article Type] Observational Study