Treatment Outcomes of Tocilizumab in Critically-Ill COVID-19 Patients, Single-Centre Retrospective StudyArticle Published on 2022-02-122022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] administration Arthritis characterized COVID-19 CRP Cytokine release syndrome D-dimer discharged dose Efficacy and safety eight evaluate ICU IL-6 IL-6 receptor immune improvement Inflammation Inflammatory marker Interlukin-6 IQR outcome Patient patients died reduced Retrospective study risk SARS-CoV-2 Seven severe COVID-19 patient TCZ temperature the median therapeutic therapy thrombosis Tocilizumab treat WHO [DOI] 10.3390/antibiotics11020241 PMC 바로가기 [Article Type] Article
Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19: a multicentre, European, observational cohort studyObservational Study Published on 2022-02-122022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] 28-day mortality 95%CI adjusted adjusted odds ratio Admission analysed chronic kidney failure COPE COVID-19 Cox proportional hazard demographic characteristics demographic data Dose-response EGFR eight European Evidence General population glomerular filtration rate Hospital stay hospitalised in-hospital mortality increased mortality independent Logistic regression median Mortality multicentre Observational cohort study Older age older patient outcome Patient prevalent Primary outcome prognostic reduced renal function renal impairment Result secondary Stage supplementary material time-to-event analysis was measured with COVID-19 [DOI] 10.1186/s12877-022-02782-5 PMC 바로가기 [Article Type] Observational Study
Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19: a multicentre, European, observational cohort studyObservational Study Published on 2022-02-122022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] 28-day mortality 95%CI adjusted adjusted odds ratio Admission analysed chronic kidney failure COPE COVID-19 Cox proportional hazard demographic characteristics demographic data Dose-response EGFR eight European Evidence General population glomerular filtration rate Hospital stay hospitalised in-hospital mortality increased mortality independent Logistic regression median Mortality multicentre Observational cohort study Older age older patient outcome Patient prevalent Primary outcome prognostic reduced renal function renal impairment Result secondary Stage supplementary material time-to-event analysis was measured with COVID-19 [DOI] 10.1186/s12877-022-02782-5 PMC 바로가기 [Article Type] Observational Study
Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virusOmicron 스파이크 단백질 및 인간 ACE-2 수용체와의 복합체 구조 모델링: 바이러스의 높은 전염성을 위한 분자 기반Article Published on 2022-02-122022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 ACE-2 receptor analysed Analysis binding complex domain eight explain glycoprotein Human Human ACE-2 receptor hydrogen Hydrogen bond infecting Infection Interaction interactions interface intra-molecular ionic interactions mutant Mutation mutations omicron Omicron variant parameter Pathogenesis Protein RBD RBD domain receptor Receptor binding domain residue Result Salt Bridge Seven simulation studies spike spike glycoprotein Spike protein Structural analysis Transmissibility trimeric Van variant of SARS-CoV-2 virus wild type [DOI] 10.1016/j.bbrc.2021.12.082 PMC 바로가기 [Article Type] Article
Moyamoya disease with Sjogren disease and autoimmune thyroiditis presenting with left intracranial hemorrhage after messenger RNA-1273 vaccination A case report5300 Published on 2022-02-112022-10-30 Journal: Medicine [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Adults approved Autoimmune Autoimmune disease brain hemorrhage Care Case report Cognitive function coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccine diagnostic discharged disease eight executive female Follow-up hematoma hemorrhage insertion Intracerebral hemorrhage intraventricular knowledge MMD Moderna moyamoya Moyamoya disease mRNA-1273 neurological pandemic Patient performed physical presenting PROTECT raise reported required risk RNA-1273 second dose Serious Adverse Event subsequent Surveillance the vaccine Thyroiditis vaccination Vaccine Vascular ventricular [DOI] 10.1097/MD.0000000000028756 PMC 바로가기 [Article Type] 5300
Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp.Article Published on 2022-02-112022-10-30 Journal: Molecules [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Artemisia commutate 2-phenoxychromones addition ADMET being binding binding energy carried co-crystallized conducted COVID-19 COVID-19 Papain-Like Protease derivative derivatives drugs eight Enzymes exhibiting in silico indicated investigated Ligand MD simulations molecular molecular docking Molecular docking study molecular fingerprints PDB PLP potentiality SARS-CoV-2 Seven similarity Simulation study thermodynamic Toxicity [DOI] 10.3390/molecules27041216 PMC 바로가기 [Article Type] Article
Clinical outcomes after IL-6 blockade in patients with COVID-19 and HIV: a case seriesCase Report Published on 2022-02-112022-10-27 Journal: AIDS Research and Therapy [Category] [키워드] admitted to ICU benefit case sery CD4 cells clinical Clinical outcome Co-infection Comprehensive Corticosteroid Corticosteroids COVID-19 died eight HIV HIV-negative Hospitalized hospitalized COVID-19 patient humanized ICU IL-6 blockade increased risk individuals Infection inhibitor mechanical ventilation monoclonal Mortality organism Organisms outcome Patient patients with COVID-19 people with HIV receptor required sarilumab severe COVID-19 severely ill patients supplementary material suppressed Tocilizumab treated use of corticosteroids Viral load with COVID-19 [DOI] 10.1186/s12981-022-00430-x PMC 바로가기 [Article Type] Case Report
Clinical outcomes after IL-6 blockade in patients with COVID-19 and HIV: a case seriesCase Report Published on 2022-02-112022-10-27 Journal: AIDS Research and Therapy [Category] COVID-19, COVID19(2023년), Fulltext, SARS, [키워드] admitted to ICU benefit case sery CD4 cells clinical Clinical outcome Co-infection Comprehensive Corticosteroid Corticosteroids COVID-19 died eight HIV HIV-negative Hospitalized hospitalized COVID-19 patient humanized ICU IL-6 blockade increased risk individuals Infection inhibitor mechanical ventilation monoclonal Mortality organism Organisms outcome Patient patients with COVID-19 people with HIV receptor required sarilumab severe COVID-19 severely ill patients supplementary material suppressed Tocilizumab treated use of corticosteroids Viral load with COVID-19 [DOI] 10.1186/s12981-022-00430-x PMC 바로가기 [Article Type] Case Report
Predicted impact of the viral mutational landscape on the cytotoxic response against SARS-CoV-2SARS-COV-2에 대한 세포 독성 반응에 대한 바이러스 돌연변이 풍경의 영향 예측 된 영향Research Article Published on 2022-02-102022-09-10 Journal: PLoS Computational Biology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] accumulation adaptive affected affecting Algorithm allele Allele families allele family alleles antibodies Asian Author C-terminal change changes in Cluster complexity country COVID-19 susceptibility Critical Cytotoxic T cell deletions eight epitope Epitopes escape escape mutation event except for extreme facilitated genetic background genetic variability genetics Genome genomic HLA class I human allele human population humans immune evasion immune response independent information integration involved isolate isolates Ligand ligands local outbreaks Mutation mutations NCBI Neutralizing occurred pandemic Pandemics Population predicted Prevent Primary infection Protective proteome protocol reduction Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome selective subpopulations Substitution Support surpassed Surveillance susceptible T cell T cell response the SARS-CoV-2 unlikely Variability variant variants Viral viral genome viral genomes viral mutation Viral mutations viral variant virus [DOI] 10.1371/journal.pcbi.1009726 PMC 바로가기 [Article Type] Research Article
Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosisResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] acute respiratory syndrome affected aggregation Analysis binding Cell circulating platelet Clinical outcome Coagulopathy coding coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical eight energy metabolism feature healthy donors Hemostasis immune response immunothrombosis implication increased mortality Interaction involved mechanism molecular mechanism multiple organ failure Pathways patients with COVID-19 performed Platelet platelet activation Platelets promoted Protein provided regulate Result reveal risk RNA RNA Polymerase II RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity significantly subunit supplementary material therapeutic strategy thrombosis thrombotic complication thrombus formation transcription factor transcriptional Transcriptome upstream with COVID-19 [DOI] 10.1186/s13578-022-00750-5 PMC 바로가기 [Article Type] Research