First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsSARS-CoV-2 및 변이체에 대한 강력한 예방 및 치료 효능을 지닌 동급 최초의 삼중특이성 VHH-Fc 기반 항체Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] ACE-2 addition antibody Antibody therapy cellular characterized comparable COVID-19 cases COVID-19 pandemic COVID-19 vaccination death Delta demonstrated distribution Drug development Efficacy Efficacy and safety epitope evaluated feature greatly reduce hospitalizations humanized Immunity in vitro in vivo intranasal lead Measures multiple epitope omicron parameter PBS prevented Prophylactic Prophylaxis provided reduced reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants shown tested the vaccine the vaccines therapeutic efficacy Treatment treatment for COVID-19 variant Viral Viral load viral loads while [DOI] 10.1038/s41598-022-07952-4 PMC 바로가기 [Article Type] Article
Editorial: First Approval of the Protein-Based Adjuvanted Nuvaxovid (NVX-CoV2373) Novavax Vaccine for SARS-CoV-2 Could Increase Vaccine Uptake and Provide Immune Protection from Viral Variants사설: SARS-CoV-2에 대한 단백질 기반 보조제 Nuvaxovid(NVX-CoV2373) Novavax 백신의 첫 번째 승인은 백신 흡수를 증가시키고 바이러스 변이체로부터 면역 보호를 제공할 수 있음Editorial Published on 2022-03-012022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 변종, 신약개발, [키워드] approval component editorial elicit EMA epitope Epitopes European European Commission European Medicines Agency full-length S protein Great Britain Healthcare Products Regulatory Agency immune response immune responses increase individual Matrix-M Medicine Medicines MHRA Novavax NVX-CoV2373 product PROTECT protection Protein recommendation S protein SARS-CoV-2 shelf life temperature the S protein the SARS-CoV-2 the vaccine union uptake Vaccine Viral variants [DOI] 10.12659/MSM.936523 PMC 바로가기 [Article Type] Editorial
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopesSARS-CoV-2 스파이크는 새로운 에피토프를 노출하는 개방형 삼량체 형태를 가역적으로 샘플링합니다.Article Published on 2022-03-012022-09-11 Journal: Nature Structural & Molecular Biology [Category] SARS, 변종, 진단, [키워드] addition antibody Antibody binding canonical conserved COVID-19 vaccine Cryo-electron microscopy current determined by diagnostics ectodomain electron microscopy epitope Epitopes help hydrogen IMPROVE Kinetics Ligand mass spectrometry modulated natural population Population prefusion prefusion conformation Protein Receptor binding receptor-binding domains SARS-CoV-2 spike sequence temperature the SARS-CoV-2 Therapeutics trimer Vaccines variant [DOI] 10.1038/s41594-022-00735-5 PMC 바로가기 [Article Type] Article
CD4 + T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronavirusesClinical Trial Published on 2022-03-012022-10-04 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, [키워드] Adaptive immunity assays bat coronavirus bat coronaviruses BNT162b2 CD4 common cold Coronaviruses conserved coronavirus Coronaviruses COVID-19 COVID-19 vaccines demonstrated elicit Endemic epitope homologous Hypothesis induce majority MERS-CoV Moderna mRNA vaccine mRNA-1273 Outbreaks Pandemics participant peptide Pfizer-BioNTech recent recipient recognize Responder SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Sequencing shown Support T cell T cell receptor T cell response vaccinated individual Vaccine zoonotic [DOI] 10.1172/JCI156083 PMC 바로가기 [Article Type] Clinical Trial
Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants다양한 SARS-CoV-2 변이체에 대한 삼중 백신 접종자의 기억 B 세포 레퍼토리Article Published on 2022-03-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, [키워드] active against antibody Antibody titre B.1.1.529 B.1.351 Beta binding class complex defined determinant dose Effectiveness epitope Epitopes examined FIVE geometric geometric mean greater human monoclonal antibodies Human monoclonal antibody immunization inactivated individual Infection Local memory B cell memory B cells mice monoclonal antibodies mutated neutralization neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody omicron Protective raising Receptor-binding domain recipient recipients regimen sarbecovirus SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant sera seroconversion rate seroconversion rates Spike protein Structure subset target the receptor-binding domain therapy Treatment Vaccine vaccine doses vaccinee vaccinees variants of concern virus [DOI] 10.1038/s41586-022-04466-x PMC 바로가기 [Article Type] Article
Seroprevalence of IgG antibodies against SARS-CoV-2 – a serial prospective cross-sectional nationwide study of residual samples, Belgium, March to October 2020SARS-CoV-2에 대한 IgG 항체의 Seroprevalence - 잔류 샘플에 대한 연속 전향적 전국 횡단 연구, 벨기에, 2020년 3월~10월Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] MERS, SARS, 진단, 치료기술, [키워드] age ambulatory patient ambulatory patients analysed Belgium COVID-19 credible interval cross-sectional detectable ELISA Epidemic epidemic waves epitope estimate Evolution exposure to fraction humoral Humoral immunity IgG antibodies IgG antibody lifted lockdown measure National performed resulting S1 protein SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 S1 epitope SARS-CoV-2 S1 protein SARS-CoV-2 seroprevalence sensitivity sera serial sero-survey Serologically Seroprevalence seroprevalence seroincidence. Seven Sex significant decrease stratified susceptibility the SARS-CoV-2 [DOI] 10.2807/1560-7917.ES.2022.27.9.2100419 PMC 바로가기 [Article Type] Article
Computationally validated SARS-CoV-2 CTL and HTL Multi-Patch vaccines, designed by reverse epitomics approach, show potential to cover large ethnically distributed human population worldwideArticle Published on 2022-03-012023-07-12 Journal: Journal of biomolecular structure & dynamics [Category] SARS, [키워드] Ag-Patch (antigenic patch) coronavirus COVID-19 epitope Multi-epitope vaccine Multi-Patch Vaccine overlapping-epitope-clusters-to-patches reverse epitomics. severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Toll-like receptor (TLR) [DOI] 10.1080/07391102.2020.1838329 PMC 바로가기
Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patientsSARS-CoV-2 핵단백질의 상세한 에피토프 매핑은 COVID-19 환자와 함께 수용된 고양이와 개에서 특정 면역 반응을 나타냅니다Article Published on 2022-03-012022-09-11 Journal: Research in veterinary science [Category] MERS, SARS, 진단, 치료법, [키워드] animals Antigen antigenic C-terminus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID19 develop disease disease control domain Double antigen ELISA ELISA epitope epitope mapping gold gold standard Human immunized Infection initial neutralization test pandemic Patient plaque PRNT Protein raising reported representing respiratory respiratory syndrome coronavirus 2 reveal SARS-CoV-2 SARS-CoV-2 nucleoprotein sera Serological assay specificity susceptible target Transmission Viral Viral antigen was used with COVID-19 [DOI] 10.1016/j.rvsc.2021.12.020 PMC 바로가기 [Article Type] Article
Elucidating important structural features for the binding affinity of spike – SARS-CoV-2 neutralizing antibody complexes스파이크의 결합 친화력에 대한 중요한 구조적 특징 규명 - SARS-CoV-2 중화 항체 복합체Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] MERS, SARS, 변종, 진단, [키워드] affected Amino acid amino acid residue analyzed antibody antigen-antibody interactions atomic binding binding affinity complexes Contact convalescent individuals coronavirus disease Coronavirus disease 2019 correlation COVID-19 develop Effect effort epitope feature Features Immune escape Interaction interactions interface lead Mutation mutational analysis Neutralizing Neutralizing antibodies neutralizing antibody pandemic parameter paratope residues provide regression analysis Regression model residue residues SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variants specific antigen Spike protein the binding affinity therapeutic intervention therapeutic interventions variants [DOI] 10.1002/prot.26277 PMC 바로가기 [Article Type] Article
Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 내 무차별 보존 CTL 에피토프 식별Coronaviruses Published on 2022-03-012022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] addition Antigen approved candidate caused CD8+ cellular immunity; HLA alleles cellular response conserved COVID-19 disease COVID-19 vaccine CTL CTL epitope CTL epitopes cytolytic Economy ELISPOT epitope Epitopes global public health HLA allele HLA alleles identification infected cells infection with SARS-CoV-2 killing MHC-I MHC-II epitope neutralizing epitopes predicted responses against SARS-CoV-2 Spike protein Spike; MHC-I epitope T cell T cell epitope T cell epitopes the disease the RBD the SARS-CoV-2 the spike protein variant Viral viral variant virus-neutralizing [DOI] 10.1080/22221751.2022.2043727 PMC 바로가기 [Article Type] Coronaviruses