A Crisis within a Crisis: COVID-19 and Hunger in African ChildrenPerspective Piece Published on 2021-01-062022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] Coronavirus, [키워드] African children COVID-19 crisis exacerbate expected expressed greater hunger Malnutrition Perspective the disease virus WHO widespread [DOI] 10.4269/ajtmh.20-1213 PMC 바로가기 [Article Type] Perspective Piece
Legionella and SARS-CoV-2 Coinfection in a Patient With Pneumonia – An Outbreak in Northern PortugalAnesthesiology Published on 2021-01-042022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome caused Coinfection Community Consequences coronavirus coronavirus disease country COVID COVID-19 diagnosed etiological exacerbate Health Health Service highlighting Legionella Outbreaks pandemic pathogen Patient Pneumonia Portugal reported SARS-CoV-2 [DOI] 10.7759/cureus.12476 PMC 바로가기 [Article Type] Anesthesiology
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysisResearch Paper Published on 2021-01-012022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] A549 ACE2 acute respiratory distress acute respiratory syndrome alteration Analysis angiotensin-converting enzyme 2 annotation applied approach bioinformatics caused cells clinical manifestation complement contribute controls coronavirus CoV COVID-19 CoVs current diagnose disease distress dysregulation effective enrichment epithelial exacerbate Gene Expression Gene ontology gene signature Genetic host cell immune system in silico induce Infection Ingenuity Pathway Analysis interferon kill Lung epithelial cells medication NHBE overexpression pandemic pathogenic coronavirus pathway Pathways performed receptor signaling Research response RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severely ill patients syndrome target upregulated gene Venn diagram Visualization were infected [DOI] 10.7150/ijms.52256 PMC 바로가기 [Article Type] Research Paper
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormonesCOVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬Review Published on 2021-01-012022-09-11 Journal: American journal of physiology. Heart and circulat [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Activation ADAM17 added angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral response Biological canonical cardiovascular disease caused contribute coronavirus COVID-19 COVID-19 pandemic Critical dependent on disease disease pathogenesis disease severity disintegrin epidemiological data exacerbate female females Gender genetics Health highlight increase in increasingly innate immune response innate immune system involved leads Loss male mechanism membrane metalloproteinase Mortality outcomes Pathways plasma positive positive feedback potential mechanism potential mechanisms protective mechanism proteolytic cleavage RAS receptor Renin renin-angiotensin system SARS epidemic SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection severe disease Sex sex differences sex hormone Sex hormones susceptibility the SARS-CoV-2 Viral viral entry worsened [DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review
Hypertension, medications, and risk of severe COVID-19: A Massachusetts community-based observational studyObservational Study Published on 2021-01-012022-10-05 Journal: Journal of clinical hypertension (Greenwich, Conn. [Category] SARS, 임상, [키워드] 95% CI age analyses angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors anticoagulant medication ARB association Beta blockers Cancer cardiovascular disease Comorbidity COVID-19 COVID-19 diagnosis defined diabete diagnosed with COVID-19 elevated evaluated exacerbate health condition Hospitalization hypertension increased risk individual inhibitor investigated less Massachusett medication medications mitigate modify Mortality outcomes Patient Prevent RAS receptor recommendation remains uncertain renin-angiotensin system risk SARS-COV-2 infection severe coronavirus disease severe COVID-19 severity Support Thiazide with COVID-19 [DOI] 10.1111/jch.14101 PMC 바로가기 [Article Type] Observational Study
Psychological distress in the face of a pandemic: An observational study characterizing the impact of COVID-19 on immigrant outpatient mental healthObservational Study Published on 2021-01-012022-10-05 Journal: Psychiatry research [Category] 임상, [키워드] Anxiety average changes in COVID-19 Depression depressive disorder distress exacerbate Factor feedback food insecurity Generalized Health Linear regression mental health mental illness multivariable novel coronavirus disease outcome Outpatient pandemic participant PHQ-2 Population populations psychiatric condition psychiatry Psychological distress reported resource scale significantly increased suffered telepsychiatry Vulnerable populations were assessed worsened [DOI] 10.1016/j.psychres.2020.113595 PMC 바로가기 [Article Type] Observational Study
Cognitive impact of COVID-19: looking beyond the short termReview Published on 2020-12-302022-10-28 Journal: Alzheimer's Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] accelerate accumulating ACE inhibitor ACE-2 acute illness angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors angiotensin-converting enzyme-2 ApoE cardiorespiratory Central nervous system cerebral classical CNS Cognitive function Cognitive impairment COVID-19 COVID-19 patient current Dementia deplete develop disease Disseminated intravascular coagulation dysfunction Endothelial cell endothelial cells Evidence exacerbate exacerbating expression Follow-up hospitalised patient immune activation increased risk individuals infecting Inflammation inflammatory effect Lewy body Limited lowest medication Meta-analysis nasal mucosa Neurological complication neurons olfactory pathology Patient pericyte pericytes Phosphorylation predicted Protective RAS recent receptor reducing Respiratory disease Respiratory function risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virus Spread stroke suggested Survivors target therapy thrombosis vascular leakage vasculature virus White matter ischaemia [DOI] 10.1186/s13195-020-00744-w PMC 바로가기 [Article Type] Review
Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19SARS-CoV-2에 의한 내피 감염 및 조절 장애: COVID-19의 증거 및 주의 사항Review Published on 2020-12-262022-09-10 Journal: Viruses [Category] MERS, SARS, 치료제, [키워드] ACE2 acute respiratory syndrome ADAM17 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding bradykinin–kallikrein pathway caused cellular receptor clinical development Complication contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Deleterious direct infection downregulation dysfunction Endothelial cell endothelial cells Endothelial dysfunction Endothelium event Evidence evidence of exacerbate global public health human lung immunothrombosis include infect Inflammatory lead manifestation Neurological diseases pandemic parameter pericyte Protein RAAS recent renal respiratory Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe COVID-19 severe disease spike Spike protein therapeutic agent therapeutic agents Therapeutics thrombotic Viral viral spike protein [DOI] 10.3390/v13010029 PMC 바로가기 [Article Type] Review
Venous Thromboembolism Has a Variable Time of Occurrence in the Course of COVID-19: A Case SeriesInternal Medicine Published on 2020-12-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome administration anticoagulation appear ARDS Complication coronavirus disease Coronavirus-2 COVID-19 diagnostic disease distress Doppler early diagnosis exacerbate Hospitalization identify implication Injury nephropathy Occurrence outcome Patient patients with COVID-19 Prevent prognostic reduce risk SARS-CoV-2 Sery syndrome the timing therapeutic option time transfer Transmissibility variable venous Venous Thromboembolism venous thromboembolism (VTE) VTE worsening [DOI] 10.7759/cureus.12295 PMC 바로가기 [Article Type] Internal Medicine
Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?Review Article Published on 2020-12-252022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] administration animal model approach benefit biogenesis bronchitis candidate cathepsin Cell cell entry cleavage complex compounds contributed CoV COVID‐19 COVID‐19 Cytokine release syndrome disease pathogenesis Disease progression disrupt disrupting drug Efficacy endocytic endosomal complexes required for transport endosomal pH entry pathway envelope exacerbate Exosome Exosomes extracellular vesicle Extracellular vesicles glycosylation Golgi Infection inhibit inhibiting inhibitor involved mechanism membrane mice Microvesicles multivesicular body occur Pathogenesis plasma membrane PPI promote Pulmonary edema pulmonary epithelial cell reported serine protease TMPRSS2 Spike protein suggested therapeutic Transport Vesicle viral endocytosis viroporin viruses [DOI] 10.14814/phy2.14649 PMC 바로가기 [Article Type] Review Article