The COVID-19-designated hospitals in China: preparing for public health emergenciesArticle Commentary Published on 2021-06-032022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] approach Care centralized response and action system China Chinese Comprehensive COVID-19 COVID-19 epidemic COVID-19 pandemic Efficacy Emergencies emergency situation functions Government Health hospital Local National Nosocomial infection pandemic patients prevention public health public health emergency required Shanghai spread of COVID-19 System [DOI] 10.1080/22221751.2021.1931467 PMC 바로가기 [Article Type] Article Commentary
Interleukin-6: obstacles to targeting a complex cytokine in critical illness인터루킨-6: 중환자에서 복잡한 사이토카인을 표적으로 하는 장애물Review Published on 2021-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome anti-IL-6 Anti-inflammatory approach approaches Biomarker Blood complex Concentration Critical Critical care cytokine disease effective Elevation elevations explain functions Health IL-6 IL-6 inhibition implication interleukin-6 Interpretation lung occur Patient physiological pleiotropic pro-inflammatory respiratory distress Sepsis serum Serum IL-6 severe COVID-19 syndrome therapeutic target Tocilizumab Treatment [DOI] 10.1016/S2213-2600(21)00103-X PMC 바로가기 [Article Type] Review
Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal ImplicationsReview Published on 2021-06-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury Acute kidney injury (AKI) AKI alteration anti-apoptotic anti-infection Anti-inflammatory approach Blood cholesterol clinical study complications Course disease dysfunctional HDL dysregulated elements Endothelial dysfunction feature functions HDL HDLs high risk High-density lipoprotein Host immune response Inflammation Inflammatory diseases intensive care involved kidney dysfunction lipid metabolism lipid profile changes liver mechanism Mild moderate Mortality MOST Particles Patient pleiotropic proteomic Renal involvement role SARS-CoV-2 SARS-COV-2 infection Sepsis serum significant changes in systemic inflammatory diseases systemic inflammatory response Therapies tissue Transport [DOI] 10.3390/ijms22115980 PMC 바로가기 [Article Type] Review
Endophytes: the novel sources for plant terpenoid biosynthesisEndophytes: 식물 테르페노이드 생합성을 위한 새로운 소스Review Published on 2021-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] SARS, 유전자 메커니즘, [키워드] antiviral activities applied Biosynthesis biosynthetic Biotransformation can not Cell Clinical treatment Compound compounds COVID-19 Endophyte Enzymes functions Genes heterologous expression Host IMPROVE in vivo International mechanism microbial Microbial cell factory multiomics plants platform Prevent problem Research resource Signal transduction strain Synthetic biology terpenoid Terpenoid. [DOI] 10.1007/s00253-021-11350-7 PMC 바로가기 [Article Type] Review
Expeditious COVID-19 similarity measure tool based on consolidated SCA algorithm with mutation and opposition operatorsResearch article Published on 2021-06-012022-10-05 Journal: Applied Soft Computing [Category] 변종, [키워드] Algorithm applied average bioinformatics COVID-19 COVID-19 virus Data analysis ENhance evaluated functions global pandemic highest Local Mutation operator Pairwise global alignment Particle swarm optimization algorithm presenting Prevent PSO sequence similarity Sine–Cosine optimization algorithm virus was tested was used [DOI] 10.1016/j.asoc.2021.107197 [Article Type] Research article
COVID-19 pandemic: what about the gonads?COVID-19 전염병: 생식선은 어떻습니까?Review Published on 2021-06-012022-09-11 Journal: Hormones (Athens, Greece) [Category] SARS, 유전자 메커니즘, [키워드] accumulating addition Affect affected alcohol androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 both sexes concerning country COVID-19 disease enzyme Estrogen Evidence Fertility functions Gender genders Genetic Gonads immunological indicate infecting Interaction mechanism organ organs question SARS-CoV-2 SARS-COV-2 infection Serine serine protease severity Sex smoking spread to Steroids supported the disease transmembrane serine protease transmembrane serine protease 2 Treatment [DOI] 10.1007/s42000-021-00277-3 PMC 바로가기 [Article Type] Review
Neuropsychological Pattern in a Series of Post-Acute COVID-19 Patients in a Rehabilitation Unit: Retrospective Analysis and Correlation with Functional OutcomesCase Report Published on 2021-05-312022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Admission alteration analyzed Anxiety assessment Barthel Index battery Brescia cognitive complex correlated correlation COVID-19 COVID-19 infection delirium described disorder evaluated Forward Frontal functional functions impairment Insomnia intensive care unit memory Neuropsychological assessment outcomes Patient patients patients with COVID-19 pattern Pneumonia recovering from COVID-19 rehabilitation Sery Spearman subsequent Tower of London verbal [DOI] 10.3390/ijerph18115917 PMC 바로가기 [Article Type] Case Report
Association of Clinical and Immunological Characteristics With Disease Severity and Outcomes in 211 Patients With COVID-19 in Wuhan, ChinaCellular and Infection Microbiology Published on 2021-05-282022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Admission age Analysis B cells body temperature CD4+ T cells CD8+ T cell changes in clinical Clinical characteristics Clinical outcome clinician Comorbidities Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 patients CREA creatinine Critical disease deterioration Disease progression disease severity duration of fever effective intervention expression feature functions global public health higher risk Hospital stay identify IL-6 immunological immunological characteristics indicated information Laboratory liver Logistic lymphocyte lymphocyte counts lymphopenia Male sex median age non-severe cases non-severe patient non-severe patients Older age Patient patients with COVID-19 peripheral lymphocyte predominant presenting progression recruited renal Result risk risk factor selective serum Serum level Severe case severe cases Severe patient severe patients significantly subpopulations subset sustained fever Symptom university WBC White blood cell with COVID-19 Wuhan Wuhan, China [DOI] 10.3389/fcimb.2021.667487 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2TMEM41B는 SARS-CoV-2를 비롯한 다양한 코로나바이러스의 복제에 필요한 숙주인자Research Article Published on 2021-05-272022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] added alphacoronavirus Antiviral antiviral therapeutics approach approaches benefit Betacoronavirus broad spectrum Characteristics characterized cholesterol Complete complex complexes conserved contribute coronavirus COVID-19 pandemic Critical curvature Defense difficulty Diseases Endemic facilitate Factor Factors functions Future HCoV-229E health systems Host host cell host protein host proteins human coronavirus inhibit Interaction lead lifecycle Lipid loss of function membrane mobilization mutants mutate pandemic pathway performed Prevent Protein Replication replication complexes required RNA SARS-CoV-2 Stage Structure Tmem41b Viral viral escape Viral protein Viral proteins viral replication virus viruses while [DOI] 10.1371/journal.ppat.1009599 PMC 바로가기 [Article Type] Research Article
Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery혈장 내 세포외 소포체 단백질체학, 3개월 회복 후 기저질환 없는 코로나19 환자의 특성 및 잔류 흔적 밝혀Article Published on 2021-05-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] addition Alanine alanine aminotransferase alkaline phosphatase ALP ALT association bleeding cellular change characteristic Characteristics Clinical characteristics Coagulation controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Ct value defined differentially expressed discharge dysfunction EVs extracellular vesicle Extracellular vesicles functions healthy subject healthy subjects Identified immune response Immunity Increasing Inflammation inflammatory reaction Intervention involved kidney mass mass spectrometry metabolic process molecular organ organ dysfunction organ function oxygen Patient phosphatase plasma Prevent Protein proteome proteomics recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Reinfection reported reveal serum electrolyte significantly lower situation Spectrometry Stress suffered underlying disease underlying diseases unique was used [DOI] 10.1038/s41419-021-03816-3 PMC 바로가기 [Article Type] Article