Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen
정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별
Research Article
[키워드] a major
abundance
Affect
Algorithm
Antibiotic resistance
approach
approaches
array
assortment
Author
Bacterial
bacterial gene
bacterial genes
benefit
bioinformatics
candidate gene
changes in
Combination
conjunction
conserved
dataset
deep sequencing
deleted
determinant
determinants
Determining
diagnostic
dissect
Diversity
DNA binding
E. coli
effective
effort
enrichment
Escherichia
Escherichia coli
Factor
fitness
Follow-up analysis
Footprinting
found
Gene
Genes
Genetic
Genome
genomes
highest
highlight
homologue
homologues
Host
hypothetical
identify
increasingly
independent
Infection
infections
insertion
investigator
investigators
isolates
Meningitis
molecular
mouse model
Mutagenesis
mutant
novel
observation
observations
pathogen
Pathogenesis
pathogenic
pathogenic strain
pathogenic strains
Pathogens
phenotypic
phenotypic variation
phylogenetic distribution
promote
Quantitative
reported
required
Research
resource
saturated
Sepsis
Sequencing
shown
strain
Strains
suggested
therapeutic
therapeutic targets
Therapies
Tn-seq
to define
trait
transcriptional repressor
transposon
urinary tract infections
variant
Variation
virulence
virulence gene
widespread
zebrafish
[DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article