Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirusResearch Published on 2006-03-292022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate acute respiratory syndrome Antiviral antiviral gene Caco-2 Cell cell line cell lines cell types cells chemokine chemokine gene Colon Course cytokine cytokine profile cytokine response determine disease dissemination embryonic kidney Gene Expression Host IFN-α IFN-β IFN-λ1 IL-6 IL-8 Immune cell infect Infected infiltration inhibition investigated IP-10 lung marker non-immune RANTES Result SARS Coronavirus SARS patient SARS-CoV suppresse the interferon tissue Transcription triggered virus [DOI] 10.1186/1743-422X-3-17 PMC 바로가기 [Article Type] Research
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research
Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoproteinResearch Published on 2005-07-182023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] antiviral therapies envelope glycoprotein fusion Hendra virus Infection inhibition Nipah virus paramyxovirus [DOI] 10.1186/1743-422X-2-57 PMC 바로가기 [Article Type] Research
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral DrugsResearch Published on 2004-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome agents Antiviral Antiviral agents antiviral drug antiviral drugs antivirals approved caused clinical testing clinically Compound coronavirus Coronavirus infection Culture cultured cell Cytopathic effect drug effective in vitro Infectious disease inhibition inhibitors interferon interferons investigated leukocyte neuraminidase inhibitors nucleoside analogs protease inhibitors SARS virus SARS-CoV SARS-CoV infection severe Severe acute respiratory syndrome Subtypes Support transcriptase treat Treatment was used [DOI] 10.3201/eid1004.030458 PMC 바로가기 [Article Type] Research