Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications시아노박테리아—바다에서 잠재적인 생명공학 및 생물의학 응용까지Review Published on 2021-04-242022-09-10 Journal: Marine Drugs [Category] MERS, SARS, 치료제, [키워드] activities antioxidant Antiviral antiviral activity application applied biological activities biotechnological applications candidate Candidates clinical trials Compound compounds COVID-19 COVID-19 treatment cryptophycin cyanobacteria cyanovirin-N cytotoxicity demonstrated dietary supplements effective exhibited HCMV HHV-6 highlight HIV-1 HSV-1 human disease I, II Isolation marine product marine products Medical research Medicines metabolite MOST neurotoxicity ocean organism pharmacological phase phycocyanin phytoalexin Potential prokaryotic organisms Research secondary metabolites synthesis these compound these compounds total synthesis Treatment [DOI] 10.3390/md19050241 PMC 바로가기 [Article Type] Review
Algae-Derived Bioactive Molecules for the Potential Treatment of SARS-CoV-2SARS-CoV-2의 잠재적 치료를 위한 조류 유래 생리활성 분자Review Published on 2021-04-082022-09-10 Journal: Molecules [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Algae algae compounds anti-SARS-CoV-2 antibody Antiviral antiviral agent attributes bioactive entities can be used caused Compound coronavirus COVID-19 COVID-19 disease COVID-19 treatment Defense diagnostics disease Diseases Effective vaccines extreme extreme environments Health Immunity immunomodulatory immunostimulatory IMPROVE mechanism metabolite microbial molecule ocean pharmacological pharmacological uses Potential public health threat Research respiratory robust SARS-CoV-2 scientist severe acute respiratory syndrome Coronavirus Spread starting point suppress therapeutic therapeutic aspects treat unique Vaccine Viral viral infections [DOI] 10.3390/molecules26082134 PMC 바로가기 [Article Type] Review
In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M pro ) InhibitorsArticle Published on 2021-04-052022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition analyses antiviral medication BCL2L1 binding binding affinity binding energy biochemical component coronavirus COVID-19 COVID-19 pandemic cytokine death demonstrated Diseases Drug discovery ecosystem enrichment analysis greater Human immunodeficiency virus identify IL2 in silico in vitro in vivo infections inhibitor inhibitors Interaction interactions invertebrate M pro marine natural products metabolite molecular molecular docking molecular dynamics performed protease Protease inhibitor reported SARS-CoV-2 SARS-CoV-2 main protease screened Signaling stability terpene the SARS-CoV-2 treat Virtual drug screening [DOI] 10.3390/molecules26072082 PMC 바로가기 [Article Type] Article
Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study입원하지 않은 경증에서 중등도의 COVID-19 환자에서 장내 미생물군유전체 조절의 자연사 및 영향을 평가하기 위한 가상화된 임상 연구 장내 미생물군 구조에 대한 KB109의 생리학적 효과를 평가하는 병렬 그룹 연구와 함께 무작위, 공개, 전향적 연구 및 기능: 무작위 대조 연구를 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-022022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 24 hours Ability absence addition adhere Affect age Ageusia allergy analysed Anosmia Anosmia/ageusia Antacid Antibiotics Antiviral assessment assigned Autoimmune disease Bariatric surgery baseline bilevel positive airway pressure Biomarker Biomarkers biomarkers of inflammation BiPAP Blinding blocker Blood blood sample Blood samples both groups bowel bowel resection breath Care care provider Cell change Chest chest tightness chills chronic lung disease cirrhosis clinical clinical study clinical trial Cold collected Community Comorbidity comparator Patients completion Compliance component computer Concomitant medication concomitant medications concurrent condition conducted contraindications coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 in patient COVID-19 symptom COVID-19 symptoms COVID-19 testing COVID-19-related symptom COVID-19-related symptoms COVID-19–related symptom COVID-19–related symptoms CPAP Cytokines D-dimer daily dose Day defined diarrhea dissemination drug duration of symptom Effect element eligible Enrollment evaluate evaluate the effect evaluated exacerbated exclusion criteria exploratory fatigue fatty Fatty acid feasible Female patients Fever fiber Follow-up follow-up period following group Gut gut microbiome gut microbiome composition gut microbiota headache Health Health care Health Care Utilization Health status healthcare Histamine history hospital Hospital admission Hospital admissions Hospitalization Hospitalized hypoxia Identifier IgM/IgG Immunity immunomodulatory immunosuppressive immunosuppressive therapy in both group include Infection Inflammation Inflammatory biomarker Inflammatory bowel disease information Informed consent inhibitors intake Interaction investigational agent irritable bowel syndrome KB109 Laboratory laboratory measures lactating library life Liver disease Lung disease magnitude malignancy management measure Measures medication medications Medicine metabolite Microbiome microbiota Mild mild to moderate Mild to moderate COVID-19 mild to moderate disease moderate Moderate COVID-19 moderate disease modulate modulation muscle pain nasal congestion neutralization assays not limited nucleic acid number objective Open-label opinion other compound other compounds outcome outcome measure Outpatient outpatients oxygen oxygen saturation Oxygen therapy Pain parallel group participant Participation Patient patient population Period Physical examination positive airway pressure Positive test Potential pre-symptomatic pregnant Primary outcome progression proportion proportions Prospective Study PROTECT protocol protocols proton pump provided pulse Pulse oximeter Quality of life Quantitative question randomisation randomised randomised controlled study randomization Randomized randomized controlled study receive recruitment reduction Registered reported response resting position risk risk of infection Sample size screened selected self-care sensitivities Sequencing serological serology shaking short-chain fatty acids Shortness of breath Sleep sleep apnea Smartphone sore throat specific biomarker specific biomarkers Spread SSC Standard Stool stratified Study design Study protocol study visit supplementary material Swab Symptom symptomatic patient Symptomatic patients Symptoms syndrome Tablet TEAEs Telemedicine telephone temperature the patient The United States therapy time Tolerability Treatment treatment-emergent adverse event undergo United States unlikely Viral Viral load water website worsening [DOI] 10.1186/s13063-021-05157-0 PMC 바로가기 [Article Type] Letter
Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptomeArticle Published on 2021-04-012022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis analyzed Biomarker Biosynthesis Chemistry components contribute distribution Effects expression level expression profile Genetic highest include involved metabolic pathways metabolite metabolome metabolomics Molecular biology molecular mechanism oxymatrine pharmacological positively correlated profile provided Quantitative Sophora flavescen specificity tissue tissues transcript Transcriptome [DOI] 10.1038/s41598-021-86970-0 PMC 바로가기 [Article Type] Article
The faecal metabolome in COVID-19 patients is altered and associated with clinical features and gut microbesCOVID-19 환자의 대변 대사체가 변경되어 임상 특징 및 장내 미생물과 관련이 있습니다.Article Published on 2021-04-012022-09-11 Journal: Analytica chimica acta [Category] SARS, 치료기술, [키워드] absorbed Absorption Actinomyces age alteration analysed Analysis Aspergillus behenic acid butylphenol can not clinical feature Clinical features clinical information Cohort collected component Compound conducted correlated correlation COVID-19 COVID-19 patient COVID-19 patients D-pinitol digestion discharge discharged patient discharged patients faece Faeces fatty gas chromatography Gas Chromatography-Mass Spectrometry glycerol greater Gut HCs healthy control healthy controls healthy subject hospital humans hypoxanthine intestinal inflammation intestine Malnutrition mass spectrometry metabolite metabolites metabolome microbe microbiota Mycobiota not different oxalate Pathogenesis pinitol purine SARS-CoV-2 serum significantly Spearman sucrose the patient Treatment treatment of COVID-19 validation cohort [DOI] 10.1016/j.aca.2021.338267 PMC 바로가기 [Article Type] Article
Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19COVID-19 소아 환자 치료를 위한 용량 선택을 지원하기 위한 렘데시비르 및 그 대사물의 생리학적 기반 약동학 모델링Article Published on 2021-04-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 치료제, [키워드] Administered applied children clinical study compassionate use coronavirus disease Coronavirus disease 2019 COVID-19 Day described disease dosage Dosing Emergency use authorization healthy volunteer healthy volunteers indicated Inflammatory information initiated intravenous Loading dose maintain maintenance dose metabolite metabolites Model modeling pandemic pediatric Pediatric patient Pediatric patients pharmacokinetic Phase I Population predict predicted regimen Remdesivir reported Selection severe coronavirus disease Simulation Support supported syndrome therapeutic Treatment [DOI] 10.1002/cpt.2176 PMC 바로가기 [Article Type] Article
Antiviral Cyanometabolites—A ReviewReview Published on 2021-03-222022-10-28 Journal: Biomolecules [Category] Coronavirus, SARS, [키워드] ACE ACE2 active against addition Amino acid sequences Angiotensin-converting enzyme Antiviral antiviral activities antiviral drugs antiviral medicine antiviral metabolites carbohydrate COVID-19 patient cyanobacteria develop dimeric Ebola effective effort epitope expressing growth herpes simplex HIV Human immunodeficiency virus immune include Infection influenza viruses inhibit inhibited Injury lectins linear majority Medicine metabolite microorganisms monomeric oligosaccharides organ Oscillatoria peptides polysaccharide polysaccharides Protein provide recognize review risk specificity Spread stimulated sulfated therapeutic potential Treatment unique Vaccines viral infection virus viruses [DOI] 10.3390/biom11030474 PMC 바로가기 [Article Type] Review
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum인간 혈청에서 2차원 동위원소 희석 LC-MS/MS 방법을 통한 7가지 용도 변경 COVID-19 약물 렘데시비르(대사산물 GS-441524 포함), 클로로퀸, 히드록시클로로퀸, 로피나비르, 리토나비르, 파비피라비르 및 아지트로마이신의 동시 정량화Article Published on 2021-03-202022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 신약개발, 치료제, [키워드] analogue analytical column antiviral therapy Azithromycin Bioanalytical Method Validation Chloroquine Concentration controls COVID-19 COVID-19 pandemic COVID-19 patient develop Dilution drug drug candidate drugs Efficacy and safety European Medicines Agency Favipiravir GS-441524 human serum Hydroxychloroquine inaccuracy injection Isotope Isotope dilution liquid chromatography tandem mass spectrometry (ID-LC–MS/MS) Liquid chromatography Lopinavir LOPINAVIR AND RITONAVIR mass spectrometry metabolite protein precipitation protocol provided quantification quantitative assay Remdesivir Ritonavir robust sensitivity separated serum Seven Simultaneous solid phase Tandem mass spectrometry therapeutic drug Therapeutic Drug Monitoring Treatment two-dimensional Volume were used [DOI] 10.1016/j.jpba.2021.113935 PMC 바로가기 [Article Type] Article
Functional profiling of COVID-19 respiratory tract microbiomesArticle Published on 2021-03-192022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] alteration Analysis biological processe Bronchoalveolar lavage fluid carbohydrate cohorts community-acquired pneumonia Computational biology and bioinformatics connection COVID-19 COVID-19 cases COVID-19 infection decrease Degradation eight function functional global pandemic Gut healthy controls Host include increase in interact Interaction lipid metabolism Lower respiratory tract lung metabolic pathways metabolism metabolite metagenomics microbial Microbiome new coronavirus SARS-CoV-2 overlap pathway Pathways patients previous study profile protein domain Research respiratory tract respiratory viral infections responsible resulting SARS-COV-2 infection sequence sequencing data understanding viral invasion virus [DOI] 10.1038/s41598-021-85750-0 PMC 바로가기 [Article Type] Article