Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccinesCOVID-19 mRNA 백신의 면역 원성 아미노산 모티프 및 선형 에피토프Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, [키워드] Adults Amino acid approach Bacterial C-terminal domain coronavirus COVID-19 COVID-19 mRNA vaccine Critical Effectiveness elicit epitope Epitopes expressed healthy homology human coronavirus identify identity IgG Immune escape immunization immunogenic immunoprecipitate in vitro individual linear epitope linear epitopes mapped motif mRNA vaccine natural infection peptide peptides Post-vaccine primary sequence random recipients response S1 and S2 SARS-CoV SARS-CoV-2 neutralization SARS-CoV-2 spike protein Spike protein subset subunit target the SARS-CoV-2 therapy vaccination Vaccine variants were used [DOI] 10.1371/journal.pone.0252849 PMC 바로가기 [Article Type] Research Article
Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding †Chemistry Published on 2021-09-062022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] analysed Analysis automated bind binding building cleavage site cleavage sites COVID Critical docked docking drug design drug target drugs effective highlight inhibit inhibitor inhibitors initial Interaction Ligand ligands M pro maturation molecular molecular feature N-terminal peptide Peptide inhibitor Peptide Inhibitors peptides plasticity Predictive protease QM/MM SARS-CoV-2 substrates Variation [DOI] 10.1039/d1sc03628a PMC 바로가기 [Article Type] Chemistry
A Peptide-Based Assay Discriminates Individual Antibody Response to the COVID-19 Pfizer/BioNTech mRNA VaccineCommunication Published on 2021-09-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antibodies antibody Antibody Response antibody response against appear coronavirus coronavirus disease correlated COVID-19 described different time point dose effective elicited ELISA enzyme-linked immunosorbent first dose individual injection MONITOR mRNA mRNA vaccine Neutralizing antibodies neutralizing capacity pandemic peptide peptide-based peptides persistence Pfizer Pfizer/BioNTech reactive response SARS-CoV-2 selected shown Spike protein subject synthetic peptide the antibody response the SARS-CoV-2 the spike protein vaccination Vaccine was measured [DOI] 10.3390/vaccines9090987 PMC 바로가기 [Article Type] Communication
The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use인간 사용을 위한 DNA 유전자형 Aotus 원숭이에서 최초의 화학적으로 합성되고 면역원성이 높은 항-SARS-CoV-2 펩티드Immunology Published on 2021-09-032022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] analysed antibody antigenicity association Coverage COVID-19 DNA ELISA titre for inclusion highlight HLA alleles HLA-DRβ1*/Aona-DRβ host cell Human humans IFA immune protection immune response immunogenic immunogenic peptide immunological Infection long-lasting membrane MHC class MHCII MHCII-peptide-TCR complex Mild modified synthetic peptide Monkey neutralising antibody parental Patient peptide peptides Population PPIIL-propensity predicted producing Protein SARS-CoV-2 SARS-CoV-2 neutralising antibody SARS-CoV-2 spike selected serum sample severe SARS-CoV-2 Structural analysis suggested were used [DOI] 10.3389/fimmu.2021.724060 PMC 바로가기 [Article Type] Immunology
Computational screening of 645 antiviral peptides against the receptor-binding domain of the spike protein in SARS-CoV-2SARS-CoV-2에서 스파이크 단백질의 수용체 결합 도메인에 대한 645개 항바이러스 펩티드의 컴퓨터 스크리닝Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Antiviral Antiviral agents antiviral peptide binding Contact contact with Critical domain effective Efficacy enzyme exhibited feature GLU GLY guideline hACE2 hACE2 receptor higher affinity Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonding hydrophobic hydrophobic interactions in vitro in vivo inhibit inhibition inhibitor inhibitors Interaction internalization molecular dynamics Molecular dynamics simulation peptide peptides predicted Protein RBD Receptor-binding domain residue S protein SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike screened selected Small molecules Spike protein stable complex surface area the RBD the receptor-binding domain the S protein the spike protein Tolerability TYR virus [DOI] 10.1016/j.compbiomed.2021.104759 PMC 바로가기 [Article Type] Article
Resourcing, annotating, and analysing synthetic peptides of SARS-CoV-2 for immunopeptidomics and other immunological studies면역펩티도믹스 및 기타 면역학적 연구를 위한 SARS-CoV-2 합성 펩티드 자원화, 주석 달기 및 분석Article Published on 2021-09-012022-09-11 Journal: Proteomics [Category] SARS, 유전자 메커니즘, [키워드] annotation Antigen applied binding affinities caused COVID19 database dataset document Epitopes examined facilitate generate human leukocyte antigen immune immune response immune responses immunological information LC-MS leukocyte library mass spectrometry modifications MS spectra pandemic peptide peptides predicted proteome proteomic provided SARS-CoV-2 SARS-CoV-2 proteome synthetic peptide synthetic peptides T cell T cell epitope T cell epitopes Tandem mass spectrometry target targets the SARS-CoV-2 vaccination [DOI] 10.1002/pmic.202100036 PMC 바로가기 [Article Type] Article
CytokineLink: A Cytokine Communication Map to Analyse Immune Responses—Case Studies in Inflammatory Bowel Disease and COVID-19CytokineLink: 면역 반응 분석을 위한 사이토카인 커뮤니케이션 맵 - 염증성 장 질환 및 COVID-19 사례 연구Article Published on 2021-08-292022-09-12 Journal: Cells [Category] MERS, 진단, [키워드] Affect applied assigned Atla Blood blood cell Cell cell type communication Consensus contribute COVID-19 Critical cytokine Cytoscape database defined demonstrated disease downstream effort expression data highlighting homeostatic conditions Human identify immune responses immunology Infectious disease inflamed colonic tissues Inflammatory Inflammatory bowel disease Inflammatory diseases information Interaction interactions intercellular Intercellular communication Map molecular weight NDEx network peptides Perturbation platform prevalent Protein receptor Repository resource reveal SARS-COV-2 infection Scientific community secretion subgroup of patients target cells Therapeutic strategies tissue ulcerative colitis [DOI] 10.3390/cells10092242 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in CellsSARS-CoV-2 막 당단백질 M은 세포에서 뉴클레오캡시드 단백질 N의 도움으로 세포자멸사를 유발합니다Cellular and Infection Microbiology Published on 2021-08-252022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료법, [키워드] Activation Apoptosis assistance caspase caspase-dependent apoptosis contribute ENhance expand glycoprotein induce inhibiting Interaction life-threatening mechanism membrane membrane glycoprotein nucleocapsid protein pandemic of COVID-19 pathogenicity PDK1 PDK1-Akt signaling peptides Protein restored SARS-CoV-2 Signaling Trigger triggers Viral viral pathogenicity virus [DOI] 10.3389/fcimb.2021.706252 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Antisense Peptide Technology for Diagnostic Tests and Bioengineering Research진단 테스트 및 생명공학 연구를 위한 안티센스 펩티드 기술Review Published on 2021-08-242022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] affinity Amino acid amino acids antisense benefit binding binding site bioengineering complementary diagnostic test diagnostic tests direction example genetic code heuristic algorithm immunochemical Interaction methodology observation peptide peptides predict Probability problem problems random Randomly Receptor binding domain Research resources SARS-CoV-2 selected sequence shown technology Test the SARS-CoV-2 translation was tested [DOI] 10.3390/ijms22179106 PMC 바로가기 [Article Type] Review
Peptide Platform as a Powerful Tool in the Fight against COVID-19Article Published on 2021-08-232022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] abrogate ACE2 acute respiratory syndrome addition analyzed antibodies antibody antigenic site applicability conserved conserved RBD region coronavirus COVID-19 demonstrated Dipeptidyl peptidase 4 docking domain DPP4 drug design enzyme fatality global pandemic in vitro in vivo Infection Logistic mechanism methodology Mutation neutralization potency neutralizing antibody peptide peptide-based peptides promote protein–protein docking pseudovirus infection RBD receptor reduce Region S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected sequence spike glycoprotein the S protein therapeutic Vaccine vaccine platform Vaccines virus entry VSVpp.SARS-2S [DOI] 10.3390/v13081667 PMC 바로가기 [Article Type] Article