SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamstersSARS-CoV-2 감염은 보호 면역을 유도하고 시리아 햄스터의 전파를 제한합니다Research Article Published on 2021-02-112022-09-12 Journal: Life Science Alliance [Category] MERS, SARS, 진단, [키워드] accompanied caused close contact Critical death demonstrated develop effective vaccine Effective vaccines hamster hamsters help Immunity induce infections initial intranasal Laboratory limit Log reduction lung Lungs Median viral load morbidity MOST naïve nasal washe natural infection Neutralizing antibodies Prevent PROTECT protective immunity public health question recovered patient recovered patients Reinfection representing SARS-CoV-2 SARS-COV-2 infection severe disease significantly TCID Transmission Vaccine development viral clearance Viral pneumonia virus [DOI] 10.26508/lsa.202000886 PMC 바로가기 [Article Type] Research Article
B cell memory: understanding COVID-19B 세포 기억: COVID-19 이해Review Published on 2021-02-092022-09-12 Journal: Immunity [Category] Fulltext, MERS, 진단, [키워드] acute respiratory syndrome B cell coronavirus COVID-19 Defense Efficacy explain help immune response Infection influence mechanism memory parameter persistence produced PROTECT protective immunity Reinfection SARS-CoV-2 underlie vaccination Vaccine [DOI] 10.1016/j.immuni.2021.01.014 PMC 바로가기 [Article Type] Review
SARS Coronavirus-2 Microneutralisation and Commercial Serological Assays Correlated Closely for Some but Not All Enzyme ImmunoassaysSARS 코로나바이러스-2 미세중화 및 상업적 혈청학적 분석은 일부 효소 면역분석에 대해 밀접한 상관관계가 있지만 전부는 아님Article Published on 2021-02-042022-09-01 Journal: Viruses [Category] MERS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 antibody Antigen antigens best binding antibodies binding antibody collected convalescent plasma correlated correlation COVID-19 COVID-19 pandemic cut-off detect determinant diagnostic Donor donors Elecsy enzyme enzyme immunoassays Euroimmun expressed FIVE greater Host immune response house IgA IgG immunoassay incidence Infection information laboratory-confirmed SARS-CoV-2 infection marker microneutralisation assay negative control Neutralising Antibodies neutralising antibody neutralising antibody titre neutralising antibody titres performance Post-infection Prevalence protective immunity provide Quantitative recovered patient recovered patients reported Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody Sensitivity and specificity sera Serological testing serology Spike protein targets vaccination were assessed [DOI] 10.3390/v13020247 PMC 바로가기 [Article Type] Article
Immunity certification for COVID-19: ethical considerationsPolicy & Practice Published on 2021-02-012022-10-27 Journal: Bulletin of the World Health Organization [Category] COVID-19, MERS, [키워드] acute respiratory syndrome antibody cause coronavirus disease Coronavirus-2 country COVID-19 COVID-19 pandemic criteria Effects Health Immunity immunity passport implementation individual Infection measure pandemic Prevent protective immunity reduce reliability robust SARS-CoV-2 serological test supported threshold virus World Health Organization [DOI] 10.2471/BLT.20.280701 PMC 바로가기 [Article Type] Policy & Practice
Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 InfectionResearch Letter Published on 2021-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, [키워드] acute respiratory syndrome cats clinical symptom coronavirus coronavirus disease COVID-19 Infection Inflammation initial lack lung lesion Lung sequelae Lungs persistence persistent protective immunity Reinfection respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viral replication viruses zoonoses [DOI] 10.3201/eid2702.203884 PMC 바로가기 [Article Type] Research Letter
Immunity certification for COVID-19: ethical considerationsCOVID-19에 대한 면역 인증: 윤리적 고려 사항Policy & Practice Published on 2021-02-012022-09-12 Journal: Bulletin of the World Health Organization [Category] 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody cause coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic criteria document Effects Health Health Organization Immunity immunity passport implementation individual Infection measure pandemic present Prevent protective immunity reduce reliability respiratory rights robust SARS-CoV-2 serological test Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus supported threshold virus World Health Organization [DOI] 10.2471/BLT.20.280701 PMC 바로가기 [Article Type] Policy & Practice
Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunitySARS-CoV-2에 대한 체액 면역 반응 및 중화 항체; 병인 및 보호 면역에 미치는 영향Review Published on 2021-01-292022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] ACE2 Administered antibodies antibody approach B cells block viral entry cellular receptor characterized Clinical outcome Clinical use COVID-19 pathogenesis defined determine disease severity domain epitope glycoprotein Humoral response IgA IgM antibody immune response Immunity implication infected individual infected individuals information interact mAbs magnitude management monoclonal antibody natural infection neutralizing antibody occur other coronaviruses pandemic Pathogenesis PROTECT Protective protective immunity rapid response RBD Receptor binding domain Reinfection reported response SARS-CoV-2 Seroconversion the antibody the Spike therapy utility Vaccine Vaccines Viral protein virus Virus-specific IgG with COVID-19 [DOI] 10.1016/j.bbrc.2020.10.108 PMC 바로가기 [Article Type] Review
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individualsCOVID-19 환자 및 건강한 개인에서 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인에 대한 고정형 중화 V H 항체Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 변종, 진단, [키워드] antibody binding binding domain composed de novo develop Evidence evidence of exposure to Genes healthy individual healthy individuals heavy chain host cells Human IgA2 IgG1 IgG2 IgG3 IGHJ6 IGHV IGHV3-53 IGHV3-66 IgM IgM isotype IgM isotypes Immunoglobulin in healthy individual in vitro infected with SARS-CoV-2 inhibit inhibiting light chains memory B cell memory B cells NAb NAbs naïve B cell naïve B cells neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody no evidence of occurred Patient patients with COVID-19 produced protective immunity RBD Receptor binding domain Replication resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain somatic mutations Spike protein subtype suggested switching the RBD Viral viral infection viral infections viral replication viruses [DOI] 10.1126/scitranslmed.abd6990 PMC 바로가기 [Article Type] Research Article
The evolutionary dynamics of endemic human coronavirusesRapid Communication Published on 2021-01-202022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] accumulated acute respiratory syndrome adaptive Affect amino acid change analyzed antigenic antigenic variant average Bayesian Bayesian framework Cell changes in coronavirus Coronavirus-2 dataset Endemic endemic human coronavirus Evidence Evolution evolutionary dynamics Evolutionary rate expected gene regions Genes genetic variability glycoprotein H3N2 HCoV-229E HCoV-OC43 highest Host HPD human coronavirus human coronaviruses human pathogen IAV influenza A virus influenza vaccines less likelihood maximum mutations neutralizing antibody responses Non-synonymous mutation occurred pandemic Phylogeny Positive selection protective immunity RBD Receptor binding domain representing reservoir RNA virus S gene SARS-CoV-2 SARS-CoV-2 evolution similarities similarity stability Substitution supported target the RBD Vaccine viral entry virus [DOI] 10.1093/ve/veab020 PMC 바로가기 [Article Type] Rapid Communication
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity흰 족제비 모델에서 SARS-CoV-2 감염에 대한 용량 의존적 반응 및 보호 면역의 증거Article Published on 2021-01-042022-09-12 Journal: Nature Communications [Category] 변종, 진단, [키워드] animal model bronchopneumonia candidate vaccine clinical disease COVID-19 dosage dose dosed Endpoint endpoints Evidence ferret ferrets groups High dose induce Infection infection with SARS-CoV-2 intranasally low dose lung Lung pathology medium Mild mild infection pathology pfu progression protective immunity Replication respiratory SARS-CoV-2 SARS-COV-2 infection Therapeutics upper respiratory tract URT UTR Viral Viral RNA Viral RNA shedding viral shedding virus Virus shedding [DOI] 10.1038/s41467-020-20439-y PMC 바로가기 [Article Type] Article