Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations신경학적 징후가 있는 COVID-19 환자의 뇌척수액의 차세대 시퀀싱 및 단백질체학Immunology Published on 2021-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Ageusia alterations Analysis Anosmia Case series case sery cellular cerebrospinal fluid changes in CNS complement complement system conducted Control COVID-19 COVID-19 confirmed patients COVID-19 patient CSF detection rate Diagnosis differentially expressed difficulty feature headache Infection Interaction Macrophage macrophages manifestation neurological Neurological involvement neurological manifestation neurological manifestations Next-generation sequencing NGS non-COVID-19 patient outbreak patch Pathogenesis pathological mechanism pathway Patient patients PI3K PI3K-Akt signaling Protein proteomic Proteomic analysis proteomics reported SARS-CoV-2 SARS-CoV-2 RNA screened selected Sequencing serum sample serum samples variant [DOI] 10.3389/fimmu.2021.782731 PMC 바로가기 [Article Type] Immunology
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Article Published on 2021-12-072022-10-04 Journal: Nature Communications [Category] SARS, 임상, 진단, [키워드] Air-liquid interface airway Antiviral Cell change Critical Culture Delayed epithelial epithelial cell epithelial cell types host response IFN IFN response IFNβ induce Infection initiate innate immune response Innate immunity Interaction interferon interferon-stimulated gene interferons Mucosal immunology nasal nasal epithelium outcome paracrine Pathogenesis proteomics provided recombinant IFN response restrict SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 viral replication Single Cell Single-cell RNA sequencing tissue Transcription Transmission type I viral gene expression widespread [DOI] 10.1038/s41467-021-27318-0 PMC 바로가기 [Article Type] Article
N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometryArticle Published on 2021-12-072022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 binding acute respiratory syndrome cause change changed characterized conditions coronavirus COVID-19 D614G D614G substitution decrease diagnostic tests distribution glycan glycosylated glycosylation glycosylation site increase in Infectious diseases membrane mutant N-glycosylation profile Protein Proteins proteomics reduction in remained SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 variant secreted proteins Spike protein the SARS-CoV-2 therapeutic drug Transmission Vaccines variant virus wild type [DOI] 10.1038/s41598-021-02904-w PMC 바로가기 [Article Type] Article
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection혈장 프로테옴 지문은 SARS-COV-2 감염의 고유성과 임상 결과를 나타냅니다.Observational Study Published on 2021-12-072022-08-31 Journal: Viruses [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] ADM Analysis analyzed assist AUROC cardiovascular disease circulating clinical Clinical management Clinical outcome Comparative Course COVID-19 death determine diagnostics disease emergency department emergency medicine evaluated fatality fingerprint helping Hospital admission Hospitalization hospitalized patient IL-6 Infection Inflammation intensive care Kinetics MCP-3 pathophysiology Patient PD-L1 plasma plasma protein plasma proteins plasma samples Predictive presenting Protein proteome proteomic proteomics proximity extension assay risk prediction SARS-CoV-2 SARS-COV-2 infection Standard of care stratified subsequent supported symptoms of COVID-19 TRAIL translate [DOI] 10.3390/v13122456 PMC 바로가기 [Article Type] Observational Study
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopeniaChAdOx1 nCoV-19 백신 유도 면역 혈전성 혈소판 감소증에 대한 통찰력Article Published on 2021-12-022022-09-11 Journal: Blood [Category] SARS, 유전자 메커니즘, 진단, [키워드] abundance activated addition Adverse reaction aggregate Analysis antibody antibody production antigenic AstraZeneca Autoimmune B-cell response Biomarkers cause ChAdOx1 ChAdOx1 nCoV-19 complex complexes component determinant determinants dissemination DNA EDTA elevated ethylenediaminetetraacetic acid HEK293 heparin heparin-induced thrombocytopenia immune immune responses immunohistochemistry insight mechanism mice Microscopy Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Pathogenesis pathologic Patient patients PF4 Platelet platelet factor 4 platelet surface Platelets polyphosphate procoagulant proinflammatory Protein proteomics reaction resulting SARS-CoV-2 serum stimulate stimulated Support thrombocytopenia thromboembolic thrombosis thrombotic Thrombotic thrombocytopenia Trigger Vaccine vascular leakage virus [DOI] 10.1182/blood.2021013231 PMC 바로가기 [Article Type] Article
Proteomics advances towards developing SARS-CoV-2 therapeutics using in silico drug repurposing approachesProteomics는 in silico 약물 용도 변경 접근법을 사용하여 SARS-CoV-2 치료제 개발을 위해 발전합니다.Review Published on 2021-12-012022-09-11 Journal: Drug Discov Today Technol [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] approach Biomarker contributed COVID-19 COVID-19 pandemic Diagnosis drug Drug administration drug candidate Drug repurposing effective FDA food host proteins identify in silico in-silico interactomics molecular docking motion Prognosis proteomics Remdesivir Repurposed drugs robust SARS-CoV-2 SARS-CoV-2 protein Scientific community significantly Standing Streamline target targets the disease therapeutic therapeutic target therapeutic targets US Food and Drug Administration [DOI] 10.1016/j.ddtec.2021.06.004 PMC 바로가기 [Article Type] Review
Dynamic metabolic profiles for HBeAg seroconversion in chronic hepatitis B (CHB) patients by gas chromatography-mass spectrometry (GC-MS)Article Published on 2021-11-302023-06-12 Journal: Journal of pharmaceutical and biomedical analysis [Category] B형 간염, [키워드] Chronic Hepatitis B Drug stress HBeAg seroconversion Immunotherapy Metabolic biomarkers proteomics [DOI] 10.1016/j.jpba.2021.114349
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosisArticle Published on 2021-11-272023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] ARDS COVID-19 fibrosis IPF lung macrophages Monocytes proteomics pulmonary fibrosis SARS-CoV-2 Single-cell transcriptomics [DOI] 10.1016/j.cell.2021.11.033 PMC 바로가기 [Article Type] Article
Crosstalk Between the Immune System and Plant-Derived Nanovesicles: A Study of Allergen TransportingOriginal Research Published on 2021-11-262023-08-30 Journal: Frontiers in Bioengineering and Biotechnology [Category] E형 간염, [키워드] allergens nanovesicles proteomics sequence similarity strawberry [DOI] 10.3389/fbioe.2021.760730 PMC 바로가기 [Article Type] Original Research
Association between immunologic markers and cirrhosis in individuals with chronic hepatitis BArticle Published on 2021-11-152023-06-03 Journal: Scientific Reports [Category] B형 간염, [키워드] Epidemiology Hepatitis Infectious diseases Inflammation liver diseases proteomics [DOI] 10.1038/s41598-021-00455-8 PMC 바로가기 [Article Type] Article