SARS-CoV-2 spike – Page 25 – Communicable Diseases Research

Immunogenicity and safety of SARS-CoV-2 vaccine with immunosuppressive agents

Article

Published on 2022-01-012022-11-15
Journal: Pediatrics international : official journal of the [Category] SARS, 진단,

Immune Response to SARS-CoV-2 Vaccine in 2 Men

2명의 남성에서 SARS-CoV-2 백신에 대한 면역 반응

Article

Published on 2022-01-012022-09-12
Journal: International archives of allergy and immunology [Category] MERS, SARS, 진단,

[키워드] Analysis B cells B-cell Breg carried CD4 CD4+ CD8 CD8 T-cell CD8+ CD8+ T cell CD8+ T cells Cell cells COVID-19 dose evaluated flow cytometry follicular cell follicular helper T cells healthy subject IgG antibody immunological increase in induce lack lymphocyte magnitude memory memory B cells memory T cells monoclonal antibody naïve performed Pfizer plasmablasts receiving Regulatory regulatory lymphocytes response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-specific CD8 T cells subject subjects subset Support T cell TCM TEM TEMRA Total transitional B cells Treg Trial vaccination Vaccine Vaccines virus zone
[DOI] 10.1159/000520046 PMC 바로가기 [Article Type] Article

Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab

오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 체액 및 T 세포 반응

Article

Published on 2022-01-012022-09-11
Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, 치료기술,

[키워드] Absolute lymphocyte count adaptive Adaptive Biotechnology age analyzed anti-CD20 therapy Anti-SARS-CoV-2 S antibodies antibody Antibody Response B and T-cell BMI CD19 characterized chemotherapeutic agents cohort study comparator conducted coronavirus coronavirus vaccine COVID COVID-19 COVID-19 epidemic Descriptive statistics detectable determine did not produce Efficacy Elecsy Eligible patients enrolled Enrollment evaluate Fisher Fisher's exact test had no humoral Humoral response IgG immune response immunoassay immunogenicity Immunoglobulin Immunoglobulin G immunosuppressive impair Infection likelihood lymphocyte Multiple multiple sclerosis Natalizumab negative antibody response no correlation Ocrelizumab Patient patients patients treated positive positive antibody response post vaccination Prevent producing question raise reduce Research response Roche SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination severity Sex shown single center T-cell T-cell Response T-cell responses Test the antibody response treated Treatment vaccination Vaccine vaccine immunogenicity variable was performed were excluded Wilcoxon rank sum
[DOI] 10.1016/j.msard.2021.103382 PMC 바로가기 [Article Type] Article

Immunogenicity and safety of AZD1222 (ChAdOx1 nCoV-19) against SARS-CoV-2 in Japan: a double-blind, randomized controlled phase 1/2 trial

일본에서 SARS-CoV-2에 대한 AZD1222(ChAdOx1 nCoV-19)의 면역원성과 안전성: 이중 맹검, 무작위 대조 1/2상 시험

Clinical Trial

Published on 2022-01-012022-09-12
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 임상, 진단,

[키워드] acute respiratory syndrome adverse event AEs age antibody Antigen AZD1222 body temperature ChAdOx1 ChAdOx1 nCoV-19 Cohort collected common Coronavirus-2 COVID-19 Day death domain dose double-blind elderly Elderly adult elevated elicited endpoints evaluated fatigue headache humoral immune response Humoral response immunogenicity injection Intramuscular injection Japan Japanese malaise Pain parallel-group participant Participants Placebo placebo-controlled Randomized receive receiving reported SARS-CoV-2 SARS-CoV-2 spike serious AE seronegative severity stratified Trial Vaccine
[DOI] 10.1016/j.ijid.2021.10.030 PMC 바로가기 [Article Type] Clinical Trial

The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein’s subcellular localization, palmitoylation and pseudovirus entry

SARS-COV-2 스파이크 (S)와 ZDHHC5/GOLGA7의 상호 작용 및 S 단백질의 세포 내 위치, 팔미 토일 화 및 슈도 바이러스 진입에 미치는 영향

Research

Published on 2021-12-272022-09-10
Journal: Virology Journal [Category] SARS, 치료기술,

[키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus Affect affected Affinity purification analyzed Antiviral APT2 assays Biotin Cas9 Cell cell line cell lines cell types cells co-immunoprecipitation co-IP Colocalization complex coronavirus CRISPR CRISPR-Cas9 cysteine cysteine residue determine domain Effect Efficiency endodomain enzymatic activity enzyme fluorescence microscopy GOLGA7 had no HEK293T HEK293T cell HEK293T cells Hela HeLa cells host protein host proteins independent independent of interact Interaction knowledge mass spectrometry no significant effect palmitoylation Protein provide pseudovirus entry reason Renilla Renilla luciferase respiratory Result S protein S proteins SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S protein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect significantly Spike protein subcellular localization the cell the S protein virus entry virus infection Virus-host interaction ZDHHC5 ZDHHC5/GOLGA7
[DOI] 10.1186/s12985-021-01722-w PMC 바로가기 [Article Type] Research

Thromboses and Hemostasis Disorders Associated with COVID-19: The Possible Causal Role of Cross-Reactivity and Immunological Imprinting

Original Article

Published on 2021-12-262022-10-31
Journal: Global Medical Genetics [Category] COVID-19,

[키워드] adverse event bleeding Causal Coagulopathies commonality COVID-19 cross-reaction cross-reactive cross-reactivity Diseases disorder Epitopes extreme Hemostasis human protein human proteins immune system immunization immunological immunological imprinting Immunological memory Imprinting individual mutated natural infection pathogen pentapeptide peptide response role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike gp sequence thromboembolic thromboembolic complications thromboses thromboses-related proteins vaccinal Vascular vascular diseases Venous thrombosis
[DOI] 10.1055/s-0041-1731068 PMC 바로가기 [Article Type] Original Article

PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response

PD-1 봉쇄는 코비드 -19 면역 이상을 반대하고 항 -SARS-COV-2 면역 반응을 자극합니다.

Research Article

Published on 2021-12-222022-08-31
Journal: JCI Insight [Category] SARS, 바이오마커,

[키워드] abnormality Alter Altered among others Anergy blockade CD8 characterized coronavirus coronavirus disease coronavirus disease-2019 counteract COVID-19 COVID-19–related symptom COVID-19–related symptoms Ex vivo healthy controls hospital discharge IL-1 IL-1 β IL-1ra IL-8 immune Immune checkpoint blockade immune response immunologically immunology Immunotherapy Infection lentivirus Methylation Neutralization assay neutralize nonspecific normalized Patient patients PD-1 PD-L1 PD1 peptides plasma Plasma level Plasma levels promoter proportion pseudotyped reduced restored SARS-CoV-2 antigens SARS-CoV-2 peptides SARS-CoV-2 spike stimulate T cell T cell response T cells
[DOI] 10.1172/jci.insight.146701 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 spreads through cell-to-cell transmission

SARS-CoV-2는 세포 간 전파를 통해 확산

423

Published on 2021-12-222022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] 변종, 진단,

[키워드] (alpha (Beta ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B.1.1.7 B.1.351 Beta Cell cell-to-cell transmission cell–cell fusion Contact contribute convalescent sera coronavirus COVID-19 pandemic COVID-19 patients Critical cultures Efficiency endosomal entry ENhance enzyme Evidence feature impair implication Implications Infection inhibitor lentiviral mechanism membrane fusion neutralization neutralizing antibody Pathogenesis Pseudotyped virus reflects required respiratory responsible Result reveal SARS-CoV SARS-CoV spike SARS-CoV-2 SARS-CoV-2 spike sensitivity sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance spike glycoprotein Spike protein Spread the spike protein Transmission transmission of SARS-CoV-2 Treatment vaccinee variants of concern Viral viral cell VoC VOCs while wild type
[DOI] 10.1073/pnas.2111400119 PMC 바로가기 [Article Type] 423

Mutagenic Distinction between the Receptor-Binding and Fusion Subunits of the SARS-CoV-2 Spike Glycoprotein and Its Upshot

Article

Published on 2021-12-202022-10-28
Journal: Vaccines [Category] COVID-19,

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

Article

Published on 2021-12-202022-10-04
Journal: Nature Communications [Category] SARS, 변종,