Pre-COVID-19 Immunity to Common Cold Human Coronaviruses Induces a Recall-Type IgG Response to SARS-CoV-2 Antigens Without Cross-Neutralisation일반 감기 인간 코로나바이러스에 대한 COVID-19 이전 면역은 교차 중화 없이 SARS-CoV-2 항원에 대한 회수형 IgG 반응을 유도합니다Immunology Published on 2022-02-112022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibody Antibody Response Cold common coronaviral infection coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-protection de novo healthy donor Human humoral immune response IgA IgG IgG antibodies IgG response IgM IgM response in vitro indicated Intravenous immunoglobulin memory mounted neutralising Patient pre-existing immunity response responsible SARS-CoV-2 SARS-CoV-2 antigen sera the patient titre [DOI] 10.3389/fimmu.2022.790334 PMC 바로가기 [Article Type] Immunology
A Cross-Sectional Study of Exposure Factors Associated with Seropositivity for SARS-CoV-2 Antibodies during the Second Epidemic Wave among a Sample of the University of Corsica (France)프랑스 코르시카 대학교 표본 중 2차 유행병 기간 동안 SARS-CoV-2 항체에 대한 혈청 양성과 관련된 노출 인자에 대한 단면 연구Article Published on 2022-02-102022-09-12 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval Acute respiratory infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 IgG antibodies Blood blood sampling conducted Contact contact with Coronavirus-2 Corsica cross-sectional survey ELISA exposure Factor France house individual Infection Loss of Smell neutralization test participant Population positive Prevention and control questionnaire respiratory infection Sample SARS-CoV-2 second second wave sera seroneutralization Seropositivity Seropositivity for SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Symptom tested the epidemic university virus neutralization test VNT Wave [DOI] 10.3390/ijerph19041953 PMC 바로가기 [Article Type] Article
Identification of immunodominant epitopes on nucleocapsid and spike proteins of the SARS-CoV-2 in Iranian COVID-19 patients이란 COVID-19 환자에서 SARS-CoV-2의 뉴클레오캡시드 및 스파이크 단백질에 대한 면역우성 에피토프 식별Article Published on 2022-02-092022-09-11 Journal: Pathogens and disease [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Amino acid amino acids Analysis Antibody Response binding conformational COVID-19 COVID-19 infection COVID-19 patient determine Diagnosis diagnostic Disulfide domain dominant ELISA entire sequence enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes experiment healthy subject identification IgG response immunodominant epitope immunodominant epitopes immunogenic Immunotherapy information life-threatening linear epitopes moderate no significant difference no significant differences nucleocapsid overlapping pandemic Patient pepscan peptide peptide pools peptides Protein RBD RBD of SARS-CoV-2 reactivity Receptor binding domain Receptor-binding domain recombinant RBD protein reduced SARS-CoV-2 SARS-CoV-2 virus sera significant differences significantly lower Spike protein structural proteins target targets the RBD the SARS-CoV-2 Viral was performed western blotting [DOI] 10.1093/femspd/ftac001 PMC 바로가기 [Article Type] Article
Humoral and Cellular Responses to COVID-19 Vaccination Indicate the Need for Post-Vaccination Testing in Frail PopulationArticle Published on 2022-02-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis analyzed anti-SARS-CoV-2 anti-spike antibody antibodies antibody Antibody titer BNT162b2 vaccine cellular immunity Cellular responses controls correlation COVID-19 determine dose Efficacy Evidence flow cytometry General population humoral immune marker indicated individual individuals Infection interferon gamma measure median age neutralization titer non-responder nursing home parameter Population proportion response SARS-CoV-2 secretion sera serum serum neutralization titer significant decrease spike IgG susceptibility Testing vaccination virus [DOI] 10.3390/vaccines10020260 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchySARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다Research Article Published on 2022-02-082022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while [DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccinationArticle Published on 2022-02-082022-10-04 Journal: NPJ Vaccines [Category] 바이오마커, [키워드] Activation adjuvants Adverse reaction Adverse reactions antibody production Antibody titers Biomarker BNT162b2 circulating conducted correlated COVID-19 COVID-19 vaccination Efficacy EVs Extracellular extracellular vesicle Fever immune responses less local pain lymphocyte microRNA miRNA mRNA-based vaccine Pain pandemic Proinflammatory cytokine prospective cohort study RNA vaccines second dose sera serum systemic adverse reaction systemic symptoms TNF-α Vaccine vaccine efficacy Vesicle [DOI] 10.1038/s41541-022-00439-3 PMC 바로가기 [Article Type] Article
AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory SyndromeAKR1B10, SARS-CoV2 중증 급성 호흡기 증후군에서 사이토카인 폭풍의 방아쇠 중 하나Article Published on 2022-02-082022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] Activation Acute respiratory failure AKR1B10 Analysis biological plausibility cell types contribute COVID-19 cytokine Cytokine storm Cytokines died drug treatment enzyme experiment expression extracellular vesicle Extracellular vesicles Factor form gene encoding highlight hospitalised COVID-19 patient hospitalised COVID-19 patients Hypothesis identify IL-1β IL-6 increased expression induce Inflammation inhibitor interleukin interleukin-1β interleukin-6 involved lipopolysaccharides LPS lung lung cells Macrophage macrophages management measurement modulation Occurrence outcomes over-expression Patient pharmacological target Preventing pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines Protein reduced reducing Reductase respiratory Respiratory failure SARS-CoV2 secreted sera severe forms of COVID-19 severity significantly storm systemic impact the cytokine storm the disease TNF α TNFα transcriptomic data transferred treated Trigger Tumor tumor necrosis tumor necrosis factor [DOI] 10.3390/ijms23031911 PMC 바로가기 [Article Type] Article
The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine candidateSARS-CoV-2의 인간 ACE-2 수용체 결합 도메인은 비복제 바이러스 벡터 백신 후보로서 뉴캐슬병 바이러스의 바이러스 표면에서 발현Research Article Published on 2022-02-082022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor addition alum Antibody titer binding domain caused Concentration COVID-19 vaccine death demonstrated elect Express expressed Health health problem Human inactivated Infection inoculated mice neutralization Neutralizing antibodies neutralizing antibody newcastle disease virus optical density pandemic disease protective immunity pseudovirus RBD RBD protein Receptor-binding domain sandwich ELISA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus sera Spread TCID the receptor-binding domain the SARS-CoV-2 viral surface Viral vector vaccine virus were measured [DOI] 10.1371/journal.pone.0263684 PMC 바로가기 [Article Type] Research Article
Robust validation and performance comparison of immunogenicity assays assessing IgG and neutralizing antibodies to SARS-CoV-2SARS-COV-2에 대한 IgG 및 중화 항체를 평가하는 면역 원성 분석의 강력한 검증 및 성능 비교Research Article Published on 2022-02-072022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein antibody Antibody titer Antibody titers approach Benchmarking calibrated convalescent coronavirus coronavirus disease Coronavirus disease 2019 correlation criteria cross-reactivity demonstrated domain donors ECL functional functional immune response human serum IgG immune response immune responses immunogenicity immunogenicity assay immunogenicity assays immunogenicity data Immunoglobulin Immunoglobulin G International international units Meso Scale Discovery microneutralization MNT MSD multiplex Neutralizing activity Neutralizing antibodies neutralizing antibody nucleocapsid outcome Precision Protein Quantitative RBD RBD protein RBD proteins reference standard regimens Reporting respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike SARS-CoV-2 vaccination scale seasonal coronaviruses selectivity sera serologic severe acute respiratory syndrome Coronavirus specificity spike and RBD proteins Spike protein tested the WHO vaccinated individuals vaccination Vaccine Vaccines virus were assessed [DOI] 10.1371/journal.pone.0262922 PMC 바로가기 [Article Type] Research Article
Steep Decline in Binding Capability of SARS-CoV-2 Omicron Variant (B.1.1.529) RBD to the Antibodies in Early COVID-19 Convalescent Sera and Inactivated Vaccine Sera초기 코비드 -19 회복기 혈청 및 불활성 백신 혈청 혈청에서 항체에 대한 SARS-Cov-2 Omicron 변이체 (B.1.1.529) RBD의 결합 능력이 급격히 감소Communication Published on 2022-02-072022-09-01 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody antigens B.1.1.529 binding concern convalescent sera COVID-19 Decline delta variant dose ELISA assay ELISA assays evade greater Impact Inactivated vaccine lineage B.1 Mutation mutations new SARS-CoV-2 omicron Omicron variant produced RBD RBDs Receptor-binding domain recombinant RBD protein recombinant RBD proteins reduction in SARS-CoV-2 sequence sequences sera Sinopharm the antibody the RBD the WHO Vaccine variant variants of concern VoC [DOI] 10.3390/v14020335 PMC 바로가기 [Article Type] Communication