severe cases – Page 25 – Communicable Diseases Research

Longitudinal Profiling of Antibody Response in Patients With COVID-19 in a Tertiary Care Hospital in Beijing, China

중국 베이징의 3차 진료 병원에서 COVID-19 환자의 항체 반응에 대한 종단 프로파일링

Immunology

Published on 2021-03-152022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법,

SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19

인간 iPSC 유래 심장 세포의 SARS-CoV-2 감염은 COVID-19 환자의 심장에서 세포변성 특징을 반영합니다

Reports

Published on 2021-03-152022-09-10
Journal: Science Translational Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations Asymptomatic Autopsy autopsy specimens cardiac damage cause Cell consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytopathic damage dysfunction exposure feature heart Human Infection leads morphologic features Morphological nuclear offer Pathogenesis Patient patients patients with COVID-19 platform raise reflect reflected respiratory robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases specimen stem cell transcriptomic
[DOI] 10.1126/scitranslmed.abf7872 PMC 바로가기 [Article Type] Reports

Hypertension and Related Comorbidities as Potential Risk Factors for COVID-19 Hospitalization and Severity: A Prospective Population-Based Cohort Study

Article

Published on 2021-03-122022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Psychological distress in the academic population and its association with socio-demographic and lifestyle characteristics during COVID-19 pandemic lockdown: Results from a large multicenter Italian study

COVID-19 팬데믹 잠금 기간 동안 학계 인구의 심리적 고통과 사회-인구학적 및 생활 방식 특성과의 연관성: 대규모 다기관 이탈리아 연구 결과

Research Article

Published on 2021-03-102022-09-12
Journal: PLoS ONE [Category] MERS, SARS, 진단,

[키워드] 95% CI Anxiety association Characteristics collected conducted consequence contracting the virus contribute country covariate covariates COVID-19 pandemic cross-sectional Depression detrimental effects distress FIVE Government HADS Health health condition highest individual Influenza influenza-like symptom Influenza-like symptoms Italian Italian study Local lockdown lowest maintaining measure Mental mental health Meta-analysis mitigate multicenter multiple regression model pandemic participant performed physical physical activity physical and mental health positive COVID-19 Probability problem Promoting Psychological distress public health questionnaire reduce reported Result risk Safe scale Severe case severe cases socio-demographic student Trust variable was measured were assessed
[DOI] 10.1371/journal.pone.0248370 PMC 바로가기 [Article Type] Research Article

Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis

COVID-19의 중증 질환 및 사망률에 대한 인구 위험 요인: 글로벌 체계적인 검토 및 메타 분석

Research Article

Published on 2021-03-042022-08-13
Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, MERS, SARS,

[키워드] 95% CI active cancer adverse outcome age association Asymptomatic Cancer Characteristics characteristics of patient Comorbidities comparable conducted consolidation COVID-19 COVID-19 infection database disease severity elevated Evidence Factor heterogeneity heterogeneous identify impacted Inclusion increased risk invasive knowledge Male sex measure meta-analyses Meta-analysis methodology Mortality obesity outcome outcomes parameter Patient patients with COVID-19 Population predict profiles reported respiratory rate Result risk risk factor Risk factors risk stratification Sample size Severe case severe cases severe disease Severe obesity SpO2 Study design suggested Symptom systematic review variable while widespread with COVID-19
[DOI] 10.1371/journal.pone.0247461 PMC 바로가기 [Article Type] Research Article

The Characterization of Disease Severity Associated IgG Subclasses Response in COVID-19 Patients

COVID-19 환자의 질병 중증도 관련 IgG 하위 분류 반응의 특성화

Immunology

Published on 2021-03-042022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법,

[키워드] age analyzed antibodies Antibody Response Antigen Asymptomatic COVID-19 characterization chemokines Clinical outcome Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient cytokine cytokine production Cytokines disease disease severity dysregulated immune response dysregulated immune responses Evidence had no hospitalized patient Host immune response Ig isotype Ig isotypes IgG IgG subclasse IgG subclasses IgG1 IgG3 IL-1β immune responses Immunoglobulin Increasing isotypes Mild moderate Multiple multiple cytokines NAb activity Nasopharyngeal swab negative correlation neutralizing antibody no effect nucleocapsid protein Patient positively correlated Protein RBD Receptor binding domain response SARS-CoV-2 serum severe cases severity Sex significantly T cell T cell response T cell responses Viral Viral load was related
[DOI] 10.3389/fimmu.2021.632814 PMC 바로가기 [Article Type] Immunology

Clinical features of hypertensive patients with COVID-19 compared with a normotensive group: Single-center experience in China

Research Article

Published on 2021-03-032022-10-28
Journal: Open Medicine [Category] COVID-19,

[키워드] ACEi/ARB age analyzed Angiotensin-converting enzyme Antibiotic therapy antihypertensive drugs antiviral therapy blocker C-reactive protein China clinical Clinical features Clinical outcome collected Combination common Community Computed tomography conducted Corticosteroid cough COVID-19 COVID-19 patient COVID-19 patients CRP D-dimer demonstrated effective enrolled Epidemiology fatigue feature Fever Gender general treatment greater Ground glass opacity groups Health hospital hypertension hypertensive hypertensive patient IL-6 increased risk Inflammatory response initial International laboratory data lung median age Mild mild case morbidity and mortality no significant difference normotensive patchy Patient patients plasma receptor reported Result Safe SARS-CoV-2 severe cases severe COVID-19 severe group severe viral pneumonia significantly Spread statistically significant Symptom the median therapy treated Treatment Viral pneumonia was used with COVID-19 Wuhan
[DOI] 10.1515/med-2021-0225 PMC 바로가기 [Article Type] Research Article

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

IFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다

Report

Published on 2021-03-032022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission
[DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report

Repurposing Treatment of Wernicke–Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile

Pharmacology

Published on 2021-03-022022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Administered alcohol Anti-inflammatory clinical study condition Control COVID-19 COVID-19 cytokine storm COVID-19 patient Cytokine storm disease disorder dose doses effective Effectiveness elevated healthy volunteer humans identify IL-17 IL-22 immune in vitro study increase in Intervention literature review macrophage cell line measure metabolic conditions Neurological symptom occur pandemic Patient patients pharmacokinetic profile proinflammatory Proinflammatory cytokine Proinflammatory response repurposing respond Safe Safety Septic shock severe cases significantly storm subsequent tested Th17 Th17 response the cytokine storm Thiamine treated Treatment viral infection was performed
[DOI] 10.3389/fphar.2020.598128 PMC 바로가기 [Article Type] Pharmacology

High prevalence of occult thrombosis in cases of mild/moderate COVID-19

경증/중등도 COVID-19의 경우 잠재성 혈전증의 높은 유병률

Article

Published on 2021-03-012022-09-11
Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술,

[키워드] analyzed biochemical blood test blood tests clinical manifestations Coagulation coagulation test Computed tomography Computed tomography pulmonary angiography COVID-19 COVID-19 pneumonia CPTA CTPA distal Doppler ultrasound DVT evaluate Features incidence Inflammatory Laboratory laboratory examinations LDH limb lung Lungs Mild/moderate COVID-19 normal range parameter Patient patients with COVID-19 performed Pneumonia positive Prevalence Prognosis pulmonary angiography Research screened Screening Severe case severe cases the patient Thromboembolism thrombosis thrombotic Thrombotic complications Venous Thromboembolism VTE WBC
[DOI] 10.1016/j.ijid.2020.12.042 PMC 바로가기 [Article Type] Article