Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric StudiesSARS-CoV-2 바이러스 제거 동역학 특성화를 통해 항바이러스 약리학적 연구 설계 개선Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] analyzed Antiviral antiviral drug antiviral drugs antiviral effects antiviral treatments assessment clearance clearance rate clinical trials conducted Consensus COVID-19 illness Effect estimate exponential decay model individuals Infection Kinetics methodology Metrics molnupiravir Nasopharyngeal swab Nasopharyngeal swab samples Nirmatrelvir Patient Pharmacodynamics Phase 2 profile provide qPCR randomized trial randomized trials reduced reported robust Sample size sample sizes SARS-CoV-2 splines Statistical power time to clearance. Trial viral clearance Viral load virological response [DOI] 10.1128/aac.00192-22 PMC 바로가기 [Article Type] Article
Nasal nitric oxide is decreased in acute mild COVID-19 and related to viral loadArticle Published on 2022-07-182023-07-09 Journal: Journal of breath research [Category] COVID19(2023년), [키워드] COVID-19 fractional exhaled nitric oxide nasal nitric oxide NO SARS-CoV-2 Viral load [DOI] 10.1088/1752-7163/ac7d6a
Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trialSARS-CoV-2에 대한 구강청결제 - 시험관 내 막 파괴에 의한 높은 항바이러스 효과는 무작위 위약 대조 임상 시험에서 약한 효과로 해석됩니다.Randomized Controlled Trial Published on 2022-07-152022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Analysis antiseptic Antiseptic agents Antiviral Antiviral effect BAC benzalkonium Benzalkonium chloride can be used capsid Capsid protection assay Cell culture chloride clinical evaluation clinical evaluations COVID-19 disrupting Effect effective intervention evaluated human population in vitro inactivated Infection route Measures membrane Mild minor mouthrinse Mouthwash oral cavity placebo-controlled clinical trial qPCR Randomized reduce reduction respiratory RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 subsequent translate Transmission transmission rate transmission rates Treatment variety viral envelope Viral load viral loads Viral RNA virus was used without affecting [DOI] 10.1016/j.virusres.2022.198791 PMC 바로가기 [Article Type] Randomized Controlled Trial
Whole lung lavage: Treating pulmonary alveolar proteinosis at the time of COVID pandemicCase report Published on 2022-07-142022-10-05 Journal: Respiratory Medicine Case Reports [Category] 유전자 메커니즘, [키워드] alveolar clearance COVID COVID-19 disease dropped exacerbated hypoxemic lung lung lavage magnitude pandemic Patient Pneumonia pulmonary Pulmonary alveolar proteinosis syndrome the disease treating Treatment Viral load Whole pulmonary lavage [DOI] 10.1016/j.rmcr.2022.101707 [Article Type] Case report
Simulation of group testing scenarios can boost COVID-19 screening power그룹 테스트 시나리오의 시뮬레이션은 COVID-19 스크리닝 능력을 높일 수 있습니다Article Published on 2022-07-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] affected approach boost COVID-19 COVID-19 dissemination dependent on detect disease Disease prevalence dissemination group health system health systems individual mass mitigate positive individuals power Prevalence quarantine reagents shortage of reagent Simulation solution stages the disease Viral load [DOI] 10.1038/s41598-022-14626-8 PMC 바로가기 [Article Type] Article
Exposure modality influences viral kinetics but not respiratory outcome of COVID-19 in multiple nonhuman primate species노출 방식은 여러 비인간 영장류 종에서 바이러스 역학에 영향을 미치지만 COVID-19의 호흡기 결과에는 영향을 미치지 않습니다Article Published on 2022-07-052022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol exposure African African green monkeys AGM AGMs animal model animal models ARDS change Characteristics Chlorocebus clinical clinical response Clinical sign Clinical signs Cohort conserved COVID-19 COVID-19 disease cytokine response demonstrated demonstration develop expand exposure functional greater include infected with SARS-CoV-2 Infection influence intranasal lack lung damage magnitude Medical countermeasures mucosal mucosal exposure myeloid cell Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic status Pathogenesis Pathologies pleuritis Pulmonary pathology reached regenerative Research rhesus rhesus macaques route SARS-COV-2 infection severe disease small particle aerosol species tested therapeutic utility variants variants of concern viral kinetics Viral load [DOI] 10.1371/journal.ppat.1010618 PMC 바로가기 [Article Type] Article
Whole-genome analysis and mutation pattern of SARS-CoV-2 during first and second wave outbreak in Gwangju, Republic of Korea대한민국 광주에서 1차 및 2차 유행 중 SARS-CoV-2의 전체 게놈 분석 및 돌연변이 패턴Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed Cell culture circulating clade clinical clinical samples collected conducted Culture Deletion deletions determine dominant feature genetic diversity genomic genomic alteration high viral load in-depth analysis indicate Missense mutated Mutation Next-generation sequencing nucleic acid Nucleic acid purification outbreak Pathogenesis pathogenesis of SARS-CoV-2 Patient phylogenetic analyses Phylogenetic analysis Point mutation Proteins Region regions Research SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolates SARS-CoV-2 pathogenesis second wave significant difference South Korea statistical analysis therapeutic Viral load was performed whole genome [DOI] 10.1038/s41598-022-14989-y PMC 바로가기 [Article Type] Article
Acquired insights from the long-term surveillance of SARS-CoV-2 RNA for COVID-19 monitoring: The case of Monterrey Metropolitan Area (Mexico)COVID-19 모니터링을 위한 SARS-CoV-2 RNA의 장기 감시에서 얻은 통찰력: 몬테레이 수도권(멕시코) 사례Article Published on 2022-07-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acquired Analysis applicability applied approach Area clinical testing Community complement COVID-19 demonstrated detection rate epidemiological Epidemiology estimate feasible hospital Improvements Interpretation median MONITOR offer outbreak plant positive Prevalence ranged reported Result room RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load SARS-CoV-2 viral loads Spread statistical Surveillance tested Treatment Viral load viral titer viral titers wastewater [DOI] 10.1016/j.envres.2022.112967 PMC 바로가기 [Article Type] Article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trialRandomized Controlled Trial Published on 2022-07-012023-07-10 Journal: Dental and medical problems [Category] COVID19(2023년), [키워드] COVID-19 hypochlorous acid povidone-iodine SARS-CoV-2 Viral load [DOI] 10.17219/dmp/150831 [Article Type] Randomized Controlled Trial