Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developmentsRapid Communication Published on 2020-02-272022-10-28 Journal: The Veterinary Quarterly [Category] COVID-19, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] 2019-nCoV Analysis bat China combating coronavirus CoV death diagnostics disease effective vaccine Emergency Genetic genetic analyses Genome helping hidden highlight Host Infection mammals MERS-CoV Middle East Middle East Respiratory Syndrome CoV nCoV Novel coronavirus outbreak Perspective predict public health emergency reported Reservoir host respiratory SARS-CoV Severe Acute Respiratory Syndrome CoV Spread Therapeutics Vaccines virus virus isolation virus spread WHO World Health Organization Wuhan, China zoonose zoonoses zoonotic transmission [DOI] 10.1080/01652176.2020.1727993 PMC 바로가기 [Article Type] Rapid Communication
Distinct Roles for Sialoside and Protein Receptors in Coronavirus InfectionResearch Article Published on 2020-02-112022-10-29 Journal: mBio [Category] COVID-19, [키워드] absence adaptive adhere betacoronaviruses binding Cell cell entry cell-cell fusion contribute coronavirus CoV CoV infection CoVs disease domain engage facilitated Focusing Host host cell receptor Human identify Infection infections intercellular membrane fusion MERS-CoV Middle East murine Mutation mutations Organisms pathogen promoted Protein Proteins raise receptor receptor-binding domains receptors recognize required respiratory syndrome coronavirus role severe respiratory disease sialic acid sialic acids Spike protein Spike proteins Spread Stage stages strain subsequent supported transmembrane transmembrane protein viral spike virus virus entry virus glycoproteins virus infection virus receptors virus spread virus-cell membrane fusion was increased zoonotic zoonotic transmission [DOI] 10.1128/mBio.02764-19 PMC 바로가기 [Article Type] Research Article
A brief review of the latest pharmacological treatments of COVID-19Review Article Published on 2020-01-012022-10-31 Journal: Caspian Journal of Internal Medicine [Category] COVID-19, [키워드] 2019-nCoV article cause China Community Complete COVID-19 disease drug effective Healthcare system knowledge mechanism New Pathogenesis pharmacological pharmacological treatment Pneumonia problem SARS-CoV-2 Treatment treatments of COVID-19 Vaccine virus virus spread Wuhan [DOI] 10.22088/cjim.11.0.460 PMC 바로가기 [Article Type] Review Article
Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus EncephalomyelitisImmunology Published on 2018-12-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] adaptive anti-inflammatory cytokine anti-viral response bystander Central nervous system characterized chronic infection CNS Demyelination effective Encephalomyelitis function herpes viruses HIV Host IFN IFNα/β IFNγ IL-10 immune Immune cell immune response induce Infection interferon-γ JHMV lesions limit MHV Mortality mouse hepatitis virus neurons neurotropic pathology promote PROTECT regenerative regulated storm sustained target tissue damage tissue lesion tuning type I interferon viral infection viral persistence viral spread virus virus clearance virus replication virus spread while without affecting [DOI] 10.3389/fimmu.2018.03022 PMC 바로가기 [Article Type] Immunology
A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase LResearch Article Published on 2018-04-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] accumulate activate activating Activation Antiviral antiviral response Apoptosis ATP bind binding Cell cellular Central nervous system chimeric contributing to Coronaviruses degrade double-stranded RNA effective enzyme expressing flu IFN in vivo inactive infected cell infected cells Infection inhibit interferon killing mechanism MHV mouse hepatitis virus murine OAS oligomerization pathway Pathways Prevent produced promote Protein Replication RNase these cell triggering upstream Viral protein Viral RNA virus virus replication virus spread [DOI] 10.1371/journal.ppat.1006989 PMC 바로가기 [Article Type] Research Article
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent ResponsesCellular Response to Infection Published on 2018-02-282022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Ablation adaptive affected Antiviral Astrocyte astrocytes Cell Central nervous system CNS components contribute coronavirus Critical dissemination effective elevated elicit Encephalomyelitis evaluated expression function Gene Expression Glia histocompatibility complex IFN-α IFN-β IFN-α/β IFN-γ IFNAR immune Immunity inducer Infection infiltration initial Innate immunity Interaction interferon interferon-stimulated gene ISG ISGs lack lethal MHC MHV mice microglia Mortality mouse hepatitis virus mRNA mRNA level Neuron neurons pathway pattern recognition receptor promote PROTECT protection Protective PRRs receptor reduced Regulatory response responses robust Signaling Single Cell subsequent Support supported sustained T cell upregulated viral infection viral spread virus virus replication virus spread while [DOI] 10.1128/JVI.01901-17 PMC 바로가기 [Article Type] Cellular Response to Infection
Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmissionResearch Published on 2016-06-132022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] analyzed antibodies BCoV BCV biosecurity Blood Clinical signs concerning conducted Contact coronavirus correlated cough Depression detectable disease euthanized experiment Experimental infection fecal group Hypothesis Infection information investigated knowledge lack lymphatic tissue Mild naïve nasal nasal swabs occur pathogen potential for transmission prevention producing Prolonged provide rectal respiratory rate Respiratory system Result RNA RT-qPCR secretion seropositive supplementary material swabs temperature tissue tissue sample transmission potential Viral RNA viral shedding Viremia virus virus isolation Virus quantification Virus shedding virus spread was performed [DOI] 10.1186/s12985-016-0555-x PMC 바로가기 [Article Type] Research
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous SystemResearch Article Published on 2015-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while [DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article
Nonlytic viral spread enhanced by autophagy components자가포식 성분에 의해 강화된 비분해성 바이러스 확산journal-article Published on 2014-09-092024-08-01 Journal: Microbial Cell Factories [Category] 폴리오, [키워드] Live imaging virus spread [DOI] 10.1073/pnas.1401437111 [Article Type] journal-article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research