Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosisArticle Published on 2020-07-092022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Adults Affect age aging association Biomarker changes in children chronic infection clinical disease clinical form Cytokines determinant disease examined highest immunology Immunopathogenesis increase individual Infection Infectious diseases Inflammation Inflammatory Inflammatory response magnitude molecular multidimensional Patient patients pediatric Perspective plasma biomarker presenting profile reduce Sex significant increases in statistical analysis subpopulation systemic inflammation systemic inflammatory TB patients therapy Tuberculosis unique [DOI] 10.1038/s41598-020-68255-0 PMC 바로가기 [Article Type] Article
Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusionResearch Article Published on 2020-07-092022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 ACE2 ortholog ACE2 receptor Activation airway bat cell entry coronavirus Efficiency ENhance entry receptor enzyme evade examined exhibited highest highlight human ACE2 humans IFITM IFITM3 IFITMs infect Infection Like membrane fusion Patient protease TMPRSS2 Pseudotyped virus receptor risk SARS-CoV SARS-CoV-2 SARS-like coronavirus SARS-like coronavirus WIV1 SL-CoV SL-CoVs TMPRSS2 transmembrane protein viral entry virus wild animal [DOI] 10.1080/22221751.2020.1787797 PMC 바로가기 [Article Type] Research Article
Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19Original Paper Published on 2020-07-092022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] 95% CI age analysed association collected conducted confounders Coronavirus 2019 COVID-19 diabetes diagnosed examined exhibited flow cytometry highest hypertension immune response incidence Infection Isolation Logistic regression lowest Lymphocyte subset Lymphocytes Mild Neutrophil-to-lymphocyte ratio NLR patients with COVID-19 Peripheral blood sample progressed Respiratory failure retrospective cohort study risk factor severe cases severe COVID-19 severe COVID-19 illness Severe COVID-19 Infection severe group severe illness severity significantly supportive care T cell T lymphocytes Wuhan [DOI] 10.1017/S0950268820001557 PMC 바로가기 [Article Type] Original Paper
COVID-19 outbreak response, a dataset to assess mobility changes in Italy following national lockdownData Descriptor Published on 2020-07-082022-10-29 Journal: Scientific Data [Category] Coronavirus, SARS, [키워드] affected anonymously average changes in COVID-19 outbreak COVID-19 pandemic dataset death Epidemiology Europe Factor Government help highest Homo sapien infections Italian Italy Lifestyle modification location lockdown Metadata Metrics MONITOR National outbreak public health radius of gyration reported Sample technology the epidemic trajectory viral infection [DOI] 10.1038/s41597-020-00575-2 PMC 바로가기 [Article Type] Data Descriptor
Concentration-dependent mortality of chloroquine in overdose과다복용 시 클로로퀸의 농도 의존적 사망률Research Article Published on 2020-07-082022-10-31 Journal: eLife [Category] COVID-19, 말라리아, [키워드] analysed Bayesian benefit Blood Brazil bypassing calculate calculated cause changes in Chloroquine Clinical efficacy Clinical practice clinical trial clinical trials Concentration conditions correlated COVID-19 COVID-19 infections Critical determine died dosage dose drug electrical estimate Evidence France French greater healthy volunteer High dose highest Human Hydroxychloroquine indicated Laboratory test lack malaria mathematical metabolised Mortality outcome overdose overdoses Patient Pharmacodynamics pharmacokinetics potential benefits predict predicted Predictive problem prolongation prospectively studied randomised recovery regimen Regression model resulting rheumatological risk of death Safe shown Side effect Side effects single doses Stage statistical model suffered survival tested threshold threshold concentration Toxicity treating COVID-19 Treatment treatment for COVID-19 Trial trials unlikely ventricular virus [DOI] 10.7554/eLife.58631 PMC 바로가기 [Article Type] Research Article
Differences in Sense of Belonging, Pride, and Mental Health in the Daegu Metropolitan Region due to COVID-19: Comparison between the Presence and Absence of National Disaster Relief FundArticle Published on 2020-07-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] absence Belonging Care China city conducted COVID-19 COVID-19 infection Daegu Depression difference disaster disaster relief fund elicit frequency analysis Government highest individual investigated Local melancholy mental health National outbreak Presence Prevalence pride provided raise Region relief Result sense sense of belonging significant difference SPSS statistical analysis statistical significance t -test Wuhan [DOI] 10.3390/ijerph17134910 PMC 바로가기 [Article Type] Article
Evaluation of COVID-19 based on ACE2 expression in normal and cancer patientsResearch Article Published on 2020-07-072022-10-28 Journal: Open Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome Affect ARDS Cancer cancer patient cancers clinical symptom collected Colon conditions coronavirus COVID-19 digestive enzyme event expression expressions Gallbladder highest Infection intestine kidneys low expression lung lung cancer malignant tumor mechanism outbreak Patient protein expression public health receptor rectum renal Research SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility severity susceptibility symptom severity tissue upregulated urinary system vesicles with COVID-19 [DOI] 10.1515/med-2020-0208 PMC 바로가기 [Article Type] Research Article
Herpes Zoster Co-Infection in an Immunocompetent Patient With COVID-19Internal Medicine Published on 2020-07-042022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Co-infection Corona Virus Disease coronavirus COVID-19 described famciclovir Herpe herpes zoster highest highlight immunocompetent immunocompetent adults infection control manifestation Manifestations measure novel corona virus novel coronavirus disease Patient SARS-CoV-2 SARS-CoV2 Varicella-Zoster Virus variety Zoster [DOI] 10.7759/cureus.8998 PMC 바로가기 [Article Type] Internal Medicine
Provision of Psychotherapy during the COVID-19 Pandemic among Czech, German and Slovak PsychotherapistsArticle Published on 2020-07-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] average Care changed changes in Contact country COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 situation Czech Republic European fear fear of infection female female participants Gender Germany highest infected with COVID-19 investigated less lowest male mental health not differ novel coronavirus disease outbreak participant Patient patients treated provide psychotherapist psychotherapy public health remained remote psychotherapy reported Result Slovakia Spread treated Treatment virus [DOI] 10.3390/ijerph17134811 PMC 바로가기 [Article Type] Article
Low Humoral Immune Response and Ineffective Clearance of SARS-Cov-2 in a COVID-19 Patient With CLL During a 69-Day Follow-UpOncology Published on 2020-07-032022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] accumulate acute respiratory syndrome antiviral therapy B cell B cells B-cell Blood Cell chronic lymphocytic leukemia circulating clearance Clinical characteristics CLL CLL patients clone Cluster combination regimen coronavirus coronavirus disease-2019 COVID COVID-19 criteria cytoplasm deficiency demonstrated diagnosed with COVID-19 distribution early stage effective etiology female flow cytometry Follow-up help Hematological malignancy High-dose highest home quarantine hospital human-to-human transmission humoral immune response Humoral immunity IgG antibody IgM and IgG immune Ineffective ineffective clearance infected with COVID-19 Infection Intravenous immunoglobulin Isolation laboratory result leukemia Lung injury lymphocyte lymphocytosis outbreak Patient plasma prevent disease progression progeny progression reported response severe disease severe pneumonia suffered T lymphocytes therapy Viral load virus infection Wuhan, China [DOI] 10.3389/fonc.2020.01272 PMC 바로가기 [Article Type] Oncology