Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic북미 전염병 동안 숙주 인구에 대한 HIV-1 적응의 유전형 및 기능적 영향Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate adaptation analyzed Antiviral antiviral immunity assessment average Boston cellular immunity changes in characterized circulating codon Cohort Consensus consequence detectable enrolled Epidemic ERAS escape mutation Evolution exhibiting explain Frequency functional Gag greater HIV HIV-1 HLA Host immune immune escape mutation immune escape mutations Impact implication in vitro Increases individual information median medians Mutation New York North North America Patient persistence phenotypic Phylogeny polymorphism Polymorphisms Population Protective Protein reconstructed reduce remained replication capacity residue Result San Francisco selected sequence specimen Spread subsequent suggested Support the epidemic the median Transmission unlikely Viral viral fitness Viral proteins virus [DOI] 10.1371/journal.pgen.1004295 PMC 바로가기 [Article Type] Research Article
Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013Expedited Published on 2014-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] antibodies antibody Antibody titer Arabian Peninsula bovine Camel Camels caused coronavirus CoV Dromedary dromedary camels Epidemic Human immunofluorescence implicated infections MERS MERS cases MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus MOST outbreak recombinant reservoirs respiratory syndrome coronavirus respiratory tract infection serologic analysis serologic assay serum sample United Arab Emirate United Arab Emirates virus virus neutralization test viruses were infected [DOI] 10.3201/eid2004.131746 PMC 바로가기 [Article Type] Expedited
Serological assays for emerging coronaviruses: Challenges and pitfallsArticle Published on 2014-03-232022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] acute respiratory syndrome addition Analysis antibody Antibody detection Antigen applicability applied challenge common cold conserved Contact coronavirus CoV CoV spike protein CoVs cross-reactive antibody cross-reactivity Diagnosis diagnostic diagnostics Epidemic epitope highlight IMPROVE improvement infected individual information Isolation less majority MERS MERS-coronavirus MERS-CoV Middle East multiple method Novel viruses Nucleic acid detection nucleocapsid protein Nucleocapsid proteins occur occurred Occurrence outbreak problem public health authorities reported researcher reservoir reservoirs SARS-coronavirus SARS-CoV Sensitivity and specificity sera serological Serological assay Serological testing serology Spike protein Spread subsequent syndrome tested variety viral antigens [DOI] 10.1016/j.virusres.2014.03.018 PMC 바로가기 [Article Type] Article
How Change of Public Transportation Usage Reveals Fear of the SARS Virus in a CityResearch Article Published on 2014-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 2003 SARS acute respiratory syndrome change Chinese New Year city Epidemic fear Impact outbreak Public reported risk SARS virus School Taipei Taiwan Typhoon Nari Usage [DOI] 10.1371/journal.pone.0089405 PMC 바로가기 [Article Type] Research Article
Respiratory viruses within homeless shelters in Marseille, FranceShort Report Published on 2014-02-052022-10-27 Journal: BMC Research Notes [Category] Coronavirus, [키워드] 229E affecting asymptomatic infections asymptomatic patient clinical examination collected Community coronavirus described Epidemic finding found France high risk Homeless persons Homeless population homeless shelter HRV Human human coronavirus OC43 included Infected Influenza virus investigated isolates Local Marseille métapneumovirus MOST nasal NO outbreak Patient positive swab predominant Prevalence reported respiratory Respiratory disease respiratory symptom respiratory symptoms respiratory syncytial virus Respiratory tract disease respiratory virus rhinovirus RT-PCR detection Seasonal influenza specimen Swab the patient virus was performed [DOI] 10.1186/1756-0500-7-81 PMC 바로가기 [Article Type] Short Report
Bayesian Reconstruction of Disease Outbreaks by Combining Epidemiologic and Genomic DataResearch Article Published on 2014-01-232022-10-28 Journal: PLoS Computational Biology [Category] Coronavirus, MERS, [키워드] 2003 After Analysis approach Author Bayesian caused Containment strategy detect disease DNA early stage Epidemic Epidemics epidemiological event events genetic data genome sequence Genome sequences heterogeneous identify IMPROVE Infected infections Infectious disease information Making methodological one individual outbreak Outbreaks pathogen R package recent reconstruction respiratory Secondary infection sequence severe statistical statistically subsequent subsequent infections super-spreaders the disease Transmission transmitted understanding variety [DOI] 10.1371/journal.pcbi.1003457 PMC 바로가기 [Article Type] Research Article
Effectiveness of 10-year vaccination (2001-2010) on Hepatitis A in Tianjin, ChinaArticle Published on 2014-01-012023-05-31 Journal: Human vaccines & immunotherapeutics [Category] A형 간염, Fulltext, [키워드] Epidemic hepatitis A Hepatitis A vaccination immunization Tianjin [DOI] 10.4161/hv.27775 PMC 바로가기
Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential TherapeuticsResearch Article Published on 2013-08-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 5-FU activity antiviral activity antiviral drug Author biochemical Combination compared conserved coronavirus CoV CoV replication CoVs Critical decrease demonstrated determine Epidemic Evidence Exoribonuclease Express Genetic high mutation rate human coronavirus human disease Hypothesis identify increase in inhibitor inhibitory activity lethal MERS-CoV Middle East Mutagenesis Mutation Next-generation sequencing NO nonstructural protein 14 nsp14-ExoN nucleotides Population Potential Prevent Probability Proofreading provide RdRP Replication required respiratory responsible ribavirin RNA RNA synthesis RNA virus SARS-CoV selective sensitivity severe Support susceptible target Therapeutics to define treated Vaccine viral adaptation Viral protein viral RNA synthesis virus virus replication while wild-type zoonotic [DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
Airborne spread and infection of a novel swine-origin influenza A (H1N1) virusResearch Published on 2013-06-222023-06-07 Journal: Virology Journal [Category] 신종인플루엔자, [키워드] Airborne transmission Epidemic guinea pig pig S-O 2009 IV [DOI] 10.1186/1743-422X-10-204 PMC 바로가기 [Article Type] Research
Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral SignalingResearch Article Published on 2013-04-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Amino acid analyzed Antiviral antiviral signaling coronavirus Critical drugs drugs targeting Epidemic evade expression Factor greater help Host host gene expression host response identification inhibit inhibition inhibitory inhibitory activity innate immune response interact interferon involved led to mutant Mutation non-structural protein pathway Protein residue residues respiratory SARS-CoV severe Signaling solvent suggested susceptible virus [DOI] 10.1371/journal.pone.0062416 PMC 바로가기 [Article Type] Research Article