Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groupsResearch Article Published on 2006-10-042022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] acute respiratory syndrome adaptive addition Amino acid changes in characterized contribute coronavirus Course CoV detected different domain Epidemic epidemiological Evolution found greater group groups heptad repeat hosts human host humans membrane fusion occurred outbreak Phylogenetic tree positive Positive selection proportion Protein RBD receptor residue Result reveal S gene S protein SARS-CoV selected selective selective pressure selective sweep spike gene strain subsequent the S protein Transmission two group two groups Variation viral adaptation [DOI] 10.1186/1471-2180-6-88 PMC 바로가기 [Article Type] Research Article
Malaria Epidemics and Interventions, Kenya, Burundi, Southern Sudan, and Ethiopia, 1999–2004말라리아 유행과 개입, 케냐, 부룬디, 남수단, 에티오피아, 1999–2004Perspective Published on 2006-10-012024-08-26 Journal: Emerging Infectious Diseases [Category] 말라리아, [키워드] Burundi Epidemic Ethiopia Intervention Kenya malaria Perspective Plasmodium falciparum Sudan [DOI] 10.3201/eid1210.060540 PMC 바로가기 [Article Type] Perspective
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape MutantsResearch Article Published on 2006-07-042022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization [DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article
1951 Influenza Epidemic, England and Wales, Canada, and the United StatesArticle Published on 2006-04-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Canada England Epidemic excess mortality Immunity Influenza pandemic Pneumonia Research Transmissibility United States viral strains [DOI] 10.3201/eid1204.050695 PMC 바로가기
A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation studyResearch Article Published on 2005-10-182022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] accurate allelic Analysis approach assay can be used carried caused characteristic clinical sample Cohort different Epidemic epidemiological epidemiologically Epidemiology Genotype genotypes Infection Infectious disease information isolate MONITOR outbreak Patient probe recruited related reported respiratory Result SARS patient SARS-coronavirus Sequencing Sequencing analysis severe TaqMan the epidemic viral evolution [DOI] 10.1186/1471-2334-5-87 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
What Internet Services Would Patients Like From Hospitals During an Epidemic? Lessons From the SARS Outbreak in TorontoOriginal Paper Published on 2005-08-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affected age Analysis Care clinics communicable diseases, emerging conducted Descriptive statistics determine emergency situation English Epidemic expressed Health health condition health information Health Service help hospital identify IMPROVE infectious Infectious disease information information services international health Internet Laboratory lesson Like logistic regression model maintain mean Most patient objective organization outbreak pandemic Patient predictor professional promote provided public health Questionnaires Regression responsible restrict Result searched selected service Severe acute respiratory syndrome Toronto unique Web were used World wide web [DOI] 10.2196/jmir.7.4.e46 PMC 바로가기 [Article Type] Original Paper
Clinical evaluation of real-time PCR assays for rapid diagnosis of SARS coronavirus during outbreak and post-epidemic periodsArticle Published on 2004-12-012022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] assays average clinical clinically suspected collected Course CoV detected Diagnosis disease Epidemic evaluate exhibited facilitated Germany highlight Hong Kong Laboratory lack nucleic acid extraction outbreak PCR assay PCR assays Positive predictive value protocol Rapid diagnosis Real-time PCR real-time PCR assay respiratory specimen reverse transcription RNA extraction Roche Roche Diagnostics RT-PCR SARS Coronavirus SARS CoV SARS epidemic SARS patient sensitivity serum sample shown specificity specimen specimens Stool tested the SARS epidemic Urine WHO [DOI] 10.1016/j.jcv.2004.09.029 PMC 바로가기 [Article Type] Article
SARS-CoV Antibody Prevalence in All Hong Kong Patient ContactsDispatch Published on 2004-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 antibody Asymptomatic close contact dispatch Epidemic Hong Kong Immunoglobulin Patient positive reservoir SARS SARS Coronavirus SARS-CoV Serologically Seroprevalence subclinical infection tested virus [DOI] 10.3201/eid1009.040155 PMC 바로가기 [Article Type] Dispatch
Epidemiologic Clues to SARS Origin in ChinaResearch Published on 2004-06-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 95% confidence interval accounted acute respiratory syndrome Analysis case Case report case sery children China Clinical sign clinically communicable diseases, emerging, child, aged confirmed case Contact deaths different Epidemic FIVE Guangdong healthcare worker Hypothesis index cases observation occurred Odds ratio Older origin Patient patients pneumonia, community-acquired infections, disease outbreaks, zoonoses, China SARS Support Symptom the epidemic [DOI] 10.3201/eid1006.030852 PMC 바로가기 [Article Type] Research