benefit – Page 258 – Communicable Diseases Research

Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trial

HIV 감염의 장기 관리를 위한 프로테아제 억제제 단독 요법: 무작위, 대조, 공개, 비열등성 시험

Articles

Published on 2015-09-142022-09-06
Journal: The Lancet. HIV
[Category] Communicable Disease,

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis

Research Article

Published on 2015-09-142022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type
[DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article

In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection

Short Report

Published on 2013-12-232022-10-28
Journal: Virology Journal
[Category] Coronavirus, MERS,

[키워드] acute renal failure Angiotensin-converting-enzyme-2 ARF benefit bronchial epithelial cell bronchial epithelial cells Case report cause Cell cell type cells cellular receptor Characteristics Comparative description Dipeptidyl-peptidase-4 epithelial epithelial cell epithelial cells experiment explain finding histological staining Human coronavirus human kidney impairment individual Infected Infection infections infectious kidney kidney infection median time MERS MERS patient MERS-CoV Middle East Middle East respiratory syndrome occurred Patient peer-reviewed potential mechanism produced progeny renal Renal epithelial cells Replication respiratory reveal SARS patients SARS- and MERS-CoV SARS-CoV SD severe staining Symptom systematic review Transmission Treatment Urine
[DOI] 10.1186/1743-422X-10-359 PMC 바로가기 [Article Type] Short Report

Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen

정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별

Research Article

Published on 2013-08-222022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major abundance Affect Algorithm Antibiotic resistance approach approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish
[DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다

Research Article

Published on 2013-04-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer
[DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

Research Article

Published on 2011-06-092022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus virus infection
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article

Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice

바이오마커 검출 및 임상 실습에서 중요한 도구로서의 면역조직화학

Review

Published on 2010-02-092022-08-08
Journal: Biomarker Insights
[Category] Biochemistry,

[키워드] Amino acid amino acids Analysis benefit Cell cell or tissue antigens clinical clinician collaboration complementary detection diagnostic differential diagnose differential diagnoses eosin expression Future hematoxylin Hematoxylin and eosin immunocytochemistry immunohistochemistry immunohistochemistry technique increase in infectious agent infectious agents Interpretation involved knowledge limitations methodology pathologist pathology Patient pooling Practice preparation problem problems prognostic Protein quantification reaction related Research review specific cellular populations Stage stages surgeon technique tissue antigen
PMC 바로가기 [Article Type] Review

Identification of Upper Respiratory Tract Pathogens Using Electrochemical Detection on an Oligonucleotide Microarray

Research Article

Published on 2007-09-262022-10-28
Journal: PLoS ONE
[Category] Coronavirus,