Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine폐렴구균 집락화는 생백신 인플루엔자 백신에 대한 점막 면역 반응을 저하시킨다.Research Article Published on 2021-02-222024-07-30 Journal: JCI Insight [Category] 폐렴구균 감염증, [키워드] Adaptive immunity immunology Influenza Vaccines [DOI] 10.1172/jci.insight.141088 PMC 바로가기 [Article Type] Research Article
Use of machine learning to identify a T cell response to SARS-CoV-2기계 학습을 사용하여 SARS-CoV-2에 대한 T 세포 반응 식별Article Published on 2021-02-162022-09-11 Journal: Cell Reports Medicine [Category] 치료기술, [키워드] Accuracy adaptive Adaptive immunity antibody Applying approach available data B cell B cell receptor repertoire Beta can not cohorts coronavirus Critical disease heavy chain Hierarchical hierarchical clustering identify IGH Immunoglobulin individual Infection Longevity machine learning natural infection Patient protective immunity receptor repertoire SARS-CoV-2 SARS-COV-2 infection sensitivity sequence sequences specificity T cell T cell receptor T cell receptor repertoire T cell response T cell responses TCR TRB Vaccine-induced immunity [DOI] 10.1016/j.xcrm.2021.100192 PMC 바로가기 [Article Type] Article
SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and BeyondReview Published on 2021-02-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Adaptive immune response adaptive immune responses Adaptive immunity animal model antibodies B cell B cell response cells clinical study contribute coronavirus coronavirus disease COVID-19 develop effective Efficacy elicit germinal centers Human Immunity Infection long-lived plasma cells memory B cells Messenger RNA modulate mRNA mRNA vaccines pathogen post vaccination PROTECT Respiratory disease SARS-CoV-2 T cell T cell responses T follicular helper cells Th1 cells Vaccine while [DOI] 10.3390/vaccines9020147 PMC 바로가기 [Article Type] Review
Case Report: Adequate T and B Cell Responses in a SARS-CoV-2 Infected Patient After Immune Checkpoint Inhibition사례 보고: 면역 체크포인트 억제 후 SARS-CoV-2 감염 환자의 적절한 T 및 B 세포 반응Case Reports Published on 2021-02-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] Adaptive immune response Adaptive immunity addition Adequate Affect analyzed antibody B-cell response baseline Cancer Cell cellular chemotaxis clinician COVID-19 outbreak COVID-19 pandemic evaluate expression humoral humoral immune response IgM and IgG Immune checkpoint inhibitor Immune checkpoint inhibitors immune response immune system Immunotherapy Infection inhibition kidney neoplasms marker maturation neutralise oncology patient pandemic Patient plasma sample renal response risk factor SARS-CoV-2 subset T cell the SARS-CoV-2 therapy treated Treatment were measured [DOI] 10.3389/fimmu.2021.627186 PMC 바로가기 [Article Type] Case Reports
Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients중증 COVID-19 환자의 SARS-CoV-2에 대한 세포 면역 손상Immunology Published on 2021-02-022022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acute infection acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adaptive immune response Adaptive immunity antibody Antibody Response ARDS CD4 CD8 cellular cellular immunity convalescent individual coronavirus COVID-19 COVID-19 patient develop exhibited expression healthy controls Hospitalization humoral immune responses IFNγ Impaired individual infection rate interferon gamma MOST mounted Neutralization antibody Neutralizing antibodies NK cell pandemic percentage Peripheral blood peripheral blood lymphocyte producing reduced responses SARS-CoV-2 severe COVID-19 patient Severe patient severe patients shown significantly Spread Symptoms syndrome T cell T cells Viral proteins virus [DOI] 10.3389/fimmu.2021.603563 PMC 바로가기 [Article Type] Immunology
The COVID-19 immune landscape is dynamically and reversibly correlated with disease severityClinical Trial Published on 2021-02-012022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] acute COVID-19 Adaptive immune response Adaptive immunity alteration Analysis Clinical improvement Clusters Cohort coronavirus disease correlated Course COVID-19 critically ill patients Cytometry disease disease severity dominant dysregulated immune response family feature foundation hospitalized COVID-19 identify IL-6 pathway immune immune correlate immune response Immunity individual Innate Innate immunity Intervention Leonard longitudinal Mild moderate disease outcome Patient presenting SARS-CoV-2 severe COVID-19 severe disease specimen trajectory were used [DOI] 10.1172/JCI143648 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severityComment Published on 2021-02-012023-06-20 Journal: The Journal of Infection [Category] Fulltext, MERS, [키워드] Adaptive immunity coronavirus COVID-19 Interferonᵧ SARS-CoV-2 T-cells [DOI] 10.1016/j.jinf.2020.08.036 PMC 바로가기 [Article Type] Comment
Clinical, laboratory, and temporal predictors of neutralizing antibodies against SARS-CoV-2 among COVID-19 convalescent plasma donor candidatesCOVID-19 회복기 혈장 기증자 후보 중 SARS-CoV-2에 대한 중화 항체의 임상, 실험실 및 시간 예측인자Clinical Trial Published on 2021-02-012022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단, [키워드] 95% CI adaptive Adaptive immunity adjusted administration of plasma age Analysis antibody AOR assays candidate clinical collected convalescent individual convalescent plasma correlated COVID-19 Cutoff declined disease disease severity Donor Factor Fever Frederick Hospitalization immune immunoglobulins individual Infectious disease Laboratory laboratory assay Male sex median NAb neutralizing antibody New NIAID NIH Older age plasma Predictive predictor proportion PROTECT receiver operating characteristic Reinfection responses S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2-neutralizing antibody seronegative seropositive serum IgG severity Sex Society specimen Streamline Support supported symptom onset T cell tested transplantation treatment for COVID-19 Virology with COVID-19 [DOI] 10.1172/JCI144930 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severitySARS-CoV-2 감염은 질병 중증도와 상관관계가 있는 신속한 중화 항체 반응을 유발합니다Article Published on 2021-01-282022-09-01 Journal: Scientific Reports [Category] 진단, 치료제, [키워드] Adaptive immunity age Analysis analyzed antibody appearance association Asymptomatic individuals Cohort COVID-19 defined dependence Detection limit diagnosed disease severity elicit enrolled Gender Hospitalized hospitalized patients Humoral immunity identify immune mechanism immunology individual Infectious diseases Kinetics longitudinal longitudinal analysis magnitude Multiple Multiple regression Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing response Neutralizing titer neutralizing titers non-parametric test non-parametric tests parameters participant Particles protective effect reached replicative SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection serological significantly increased symptoms onset These data titers Treatment virological tests virus were assessed were used [DOI] 10.1038/s41598-021-81862-9 PMC 바로가기 [Article Type] Article
Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients코로나19 환자 모니터링을 위한 SARS-CoV-2 스파이크 단백질 유래 펩타이드에 대한 IgG 반응의 체계적인 평가Clinical Trial Published on 2021-01-222022-08-13 Journal: Cellular and Molecular Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] 12-mer peptide 95% CI a peptide microarray aa 1148–1159 aa 553–564 aa 577–588 aa 601–612 aa 625–636 Adaptive immunity analyzed antibody asymptomatic patient clinical centers Cohort collected combating Combination comparable Control Coverage COVID-19 cases COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients cross-reactivity Diagnosis diagnostic Diagnostic markers ELISA exhibited human coronavirus IgG IgG response independent other coronavirus other coronaviruses Patient peptide peptide microarray peptides reagent recombinant Recombinant spike protein S protein S1 protein S1–101 S1–105 S1–93 S1–97 S2–78 SARS-CoV-2 SARS-CoV-2 spike sensitivity sera serological serological test Serological tests several S protein-derived 12-mer peptides specificity spike Spike protein symptomatic and asymptomatic the S1 protein [DOI] 10.1038/s41423-020-00612-5 PMC 바로가기 [Article Type] Clinical Trial