Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfectionSARS-COV-2- 특이 적 CD4 반응의 관계 COVID-19 중증도 및 HIV-1 및 결핵 공동 감염의 영향Clinical Trial Published on 2021-06-152022-08-13 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] AIDS/HIV Antigen attributes CD4 Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity decrease Disease progression disease severity expression flow cytometry Frequency function HIV-1 HLA-DR hospitalized COVID-19 patients humoral immune response humoral immune responses immune responses implication involved knowledge magnitude Mycobacterium tuberculosis Patient patients phenotype proliferation reduced relationship SARS Coronavirus SARS-CoV-2 severe disease skewed Support T cell T cell depletion T cell response T cells the SARS-CoV-2 Tuberculosis [DOI] 10.1172/JCI149125 PMC 바로가기 [Article Type] Clinical Trial
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women임산부와 수유부에서 코로나19 mRNA 백신의 면역원성Article Published on 2021-06-152022-09-11 Journal: JAMA [Category] MERS, SARS, 변종, 진단, [키워드] antibody Antibody Response Antibody titers assays B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants binding binding and neutralizing antibodies binding domain Blood BNT162b2 breast milk CD4 CD8 T-cell response CD8 T-cell responses Cellular immune response Cord blood COVID-19 COVID-19 vaccine COVID-19 vaccine trials COVID-19 vaccines cross-reactive antibody enrolled enzyme enzyme-linked immunospot evaluate evaluated excluded exploratory Exploratory analysis Fever Follow-up functional Humoral and cellular immune responses IFN-γ immune responses immunogenic immunogenicity ImmunoSpot increased risk lactating lactating women Messenger RNA Moderna morbidity morbidity and mortality mRNA mRNA vaccine mRNA-1273 Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nonpregnant outcome Pfizer-BioNTech Phase 3 Population pregnant pregnant women preserved prospective cohort study receipt reduced reported response SARS-CoV-2 B.1.1.7 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant SARS-CoV-2 variants Spike-specific T-cell responses T-cell Response T-cell responses the SARS-CoV-2 transported vaccination Vaccine vaccine dose Viral Viral variants were assessed white women [DOI] 10.1001/jama.2021.7563 PMC 바로가기 [Article Type] Article
Multi-Epitope Vaccine Design Using an Immunoinformatic Approach for SARS-CoV-2Article Published on 2021-06-112022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Antigen applied B-cell epitope candidate caused CD19+ CD4+ CD8+ T-cell Cell Cellular immune response clinical trial COVID-19 death develop dissemination docking analysis Efficacy elicited epitope high mutation rate HLA alleles humans humoral Hydrogen bond identify IgG Immune escape immunize immunoinformatics in silico Approach Infection leukocyte lymph nodes lymphocyte mice multi-epitope peptide vaccine multiple epitope peptide peptide vaccine Prevent required SARS-CoV-2 selected serum significantly spleen T-cell T-cell epitopes the spike protein Vaccine variant viral genome [DOI] 10.3390/pathogens10060737 PMC 바로가기 [Article Type] Article
Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans인간의 SARS-COV-2 변이체에 대한 AD26.COV2.S 백신의 면역 원성Clinical Trial Published on 2021-06-092022-08-13 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine antibody antibody titres Antibody-dependent cellular phagocytosis B.1.1.7 B.1.351 B.1.351 variant B1.351 binding antibody CAL.20C CAL.20C variants CD4 CD8 cell activation Cellular immune response cellular phagocytosis Clinical efficacy clinical trial comparable complement COV1001 COVID-19 demonstrated effector memory responses fold functional functions Human humoral Humoral and cellular immune responses immune responses immunogenicity implication Killer cell median natural killer natural killer cell natural killer cell activation responses neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses non-neutralizing antibody response P.1 P.1 variants preserved pseudovirus neutralizing antibody reduced response SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants symptomatic symptomatic COVID-19 T cell T cell response T cell responses These data titre vaccinated individual vaccination Vaccine Vaccines variants WA1/2020 [DOI] 10.1038/s41586-021-03681-2 PMC 바로가기 [Article Type] Clinical Trial
Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces neutralising antibody and polyfunctional T‐cell responses in patients with chronic myeloid leukaemia중증 급성 호흡기 증후군 코로나 바이러스 -2 (SARS -COV -2)에 대한 BNT162B2 mRNA 백신의 단일 용량은 만성 골수 백혈병 환자에서 중화 항체 및 다항식 T- 세포 반응을 유도합니다.Clinical Trial Published on 2021-06-032022-08-13 Journal: British Journal of Haematology [Category] MERS, SARS, 임상, 진단, 치료제, [키워드] acute respiratory syndrome addition anti‐Spike immunoglobulin G BNT162b2 BNT162b2 vaccine CD4 CD8 Cellular immune response chronic myeloid leukaemia clinically CML develop Dilution dose evaluated haematological malignancies haematological malignancy humoral Humoral and cellular immune responses immune response immune responses immunocompromised individual immunocompromised individuals immunogenicity Immunoglobulin Immunoglobulin G induce Infection inhibit injection kinase inhibitors lymphoid haematological malignancies medium Most patients mRNA vaccine myeloid leukaemia Neutralising Antibodies neutralising antibody neutralising antibody response nine of BNT162b2 Patient patients Pfizer‐BioNTech polyfunctional response polyfunctional responses raised receiving respiratory SARS‐CoV‐2 SARS‐CoV‐2 BNT162b2 SARS‐CoV‐2 BNT162b2 vaccine SARS‐CoV2 vaccine Seroconversion serum dilution Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single dose solid and haematological malignancies solid tumour T‐cell T‐cell response targeted cancer treatment targeted cancer treatments the patient These data titre TKIs tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors vaccination Vaccine were assessed [DOI] 10.1111/bjh.17568 PMC 바로가기 [Article Type] Clinical Trial
BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans Research Published on 2021-05-272022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 임상, 치료제, [키워드] adaptive antibody BNT162b2 BNT162b2 vaccine boost CD4+ CD8+ CD8+ T cell cells Cellular immune response circulating conserved COVID-19 demonstrated detectable doses Efficacy eight elicit elicited ENCODE epitope geometric healthy Human humoral immune response individual induce Lipid nanoparticle MHC allele MOST Mutant strains neutralized Neutralizing neutralizing antibody nine nucleoside-modified mRNA observation period participant phenotype prefusion conformation presenting pseudovirus SARS-CoV-2 SARS-CoV-2 variants serum spike glycoprotein T cell T helper the SARS-CoV-2 titre Trial vaccination variants [DOI] 10.1038/s41586-021-03653-6 [Article Type] Research
Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease SeverityICU에 입원한 COVID-19 환자의 PBMC에서 손상된 세포독성 반응: 질병 중증도를 예측하는 바이오마커Immunology Published on 2021-05-262022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Admission advance Algorithm analyzed association Biomarkers blood sample Blood samples cause CD4 CD8 lymphocytes + CD8+ T cell CD8+ T cells Cell cell population Cellular immune response center COVID-19 COVID-19 severity Critical cytotoxic cytotoxic cell cytotoxic response decrease develop effort elicit feature forest form hospitalized patients ICU IL-2 immune immune response immunological parameter Impaired infected cell infected cells Inflammatory response Invasive mechanical ventilation marker MHC class I MHC class I molecules NK and NKT cells NKT Novel coronavirus novel coronavirus SARS-CoV-2 pandemic parameter Patient PBMC plasma predict pseudotyped SARS-CoV-2 Random forest recruited reduce viral replication reduced response SARS-CoV-2 SARS-COV-2 infection Spain subpopulation susceptible T cell T cells target cell target cells Th1 the disease to define translated Tregs Viral viral replication [DOI] 10.3389/fimmu.2021.665329 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다Article Published on 2021-05-252022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술, [키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type [DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article
Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirusResearch Article Published on 2021-05-242022-10-30 Journal: JCI Insight [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immunity binding Cellular immune response Clinical symptoms controls coronavirus Coronaviruses disease DNA vaccine dose effective exhibited full-length human-to-human transmission immunized Infectious disease Intradermal intramuscular lung macaque MERS-CoV MERS-CoV infection Middle East morbidity and mortality neutralizing antibody PROTECT Protein reduced regimen reservoirs respiratory syndrome coronavirus rhesus macaque rhesus macaques SARS-CoV SARS-CoV-2 severity Support Transmission vaccination Vaccine Vaccines zoonotic [DOI] 10.1172/jci.insight.146082 PMC 바로가기 [Article Type] Research Article
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice자가 증폭 RNA 및 아데노바이러스 COVID 백신을 사용한 이종 백신 요법은 생쥐에서 강력한 면역 반응을 유도합니다Article Published on 2021-05-172022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Adaptive immunity Antibody Response Antibody responses boost CD4 T cells Cellular immune response ChAdOx1 clinical trial clinical trials comparable COVID COVID-19 Cytotoxic T cell Cytotoxic T cells demonstrated disease Efficacy example Heterologous heterologous prime-boost heterologous vaccination regimen heterologous vaccination regimens homologous immune response immunogenicity induce Infectious diseases mice Neutralising titre regimen regimens RNA RNA vaccine robust SARS-CoV-2 Single-dose T cells Th1 titre titres vaccination Vaccine Vaccines vectored vaccine viral vectors [DOI] 10.1038/s41467-021-23173-1 PMC 바로가기 [Article Type] Article