Discrepant Antigen-specific Antibody Responses Causing SARS-CoV-2 Persistence in a Patient Receiving B-cell-targeted Therapy with Rituximab리툭시맙으로 B 세포 표적 치료를 받는 환자에서 SARS-CoV-2 지속성을 유발하는 불일치 항원 특이적 항체 반응Case Reports Published on 2021-01-012022-09-11 Journal: Internal medicine (Tokyo, Japan) [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] antibody Antibody Response B-cell causing clearance comparable COVID-19 highlight humoral immune response humoral immune responses immune responses Kinetics Lymphoid tissue lymphoma magnitude MONITOR mucosa-associated lymphoid tissue Neutralizing Neutralizing activity Neutralizing antibody response persistent RNAemia Pneumonia recipient recipients remained response rituximab SARS-CoV-2 SARS-COV-2 infection serological suffered therapy titer treated unique Viral [DOI] 10.2169/internalmedicine.7884-21 PMC 바로가기 [Article Type] Case Reports
COVID-19 Infection: Viral Clearance and Antibody Response in Dialysis Patients and Renal Transplant RecipientsCOVID-19 감염: 투석 환자 및 신장 이식 환자의 바이러스 제거 및 항체 반응Observational Study Published on 2021-01-012022-09-12 Journal: Nephron [Category] 임상, 진단, [키워드] activity Analysis analyzed antibodies antibody kinetics Antibody Response chronic Chronic kidney disease chronic renal failure clearance Community coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Diagnosis dialysis disease General population health emergency health-care IgG IgG and IgM IgM immune increase in Infection investigated kidney transplant recipients Kidney transplantation Laboratory testing management Nasopharyngeal swab pandemic Patient patients persistence positive recipient recipients reduction in renal renal function response serological specific antibodies subject Swab the patient Transplant Treatment viral clearance [DOI] 10.1159/000515128 PMC 바로가기 [Article Type] Observational Study
Human genetic susceptibility to hepatitis B virus infectionReview Published on 2021-01-012023-06-11 Journal: Infection, genetics and evolution : journal of mol [Category] B형 간염, [키워드] chronic infection clearance genetics Haplotype Hepatitis B virus single nucleotide polymorphisms [DOI] 10.1016/j.meegid.2020.104663 [Article Type] Review
Washing Hands according to the WHO Guideline since the COVID-19 Outbreak in the Context of Medical Undergraduates at a Tertiary Care Center: A Descriptive Cross-sectional StudyOriginal Article Published on 2020-12-312022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] COVID-19, MERS, SARS, [키워드] COVID-19 prevention hand hygiene age Analysis calculated Care clearance college Committee conducted confidence Context COVID-19 cross-sectional Data collection effective Frequency groups guideline hand hand washing hospital hygiene IMPROVE information interval Lumbini majority medical students notable online questionnaires outbreak participant Point proportion review Spread Teaching Tertiary the WHO Transmission virus was done washing World Health Organization [DOI] 10.31729/jnma.5259 PMC 바로가기 [Article Type] Original Article
PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and VirologyArticle Published on 2020-12-242022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acetylated Analysis application Bioactivity biobetter Cancer circulation clearance COVID-19 COVID-19 infection Degradation drug delivery Efficacy enhancer Escherichia coli expected expression factor 8 filtration fusion protein half-life extension HBV HCV hepatitis C virus Host immune immunostimulatory immunostimulatory peptide in vivo indicated Infection kidney limit offer PAS PASylation peptide pharmacokinetics plasma half-life problem producing provide purified renal residues resulting SEC serum therapeutic thymosin alpha 1 treatment of hepatitis viral disease Virology virus Volume [DOI] 10.3390/ijms22010124 PMC 바로가기 [Article Type] Article
Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 ReceptorsMedicine Published on 2020-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome addition aging barrier Biomarker Biomarkers caused Cell clearance contributing to coronavirus COVID-19 COVID-19 severity Defense diarrhea downregulation expression expression of SARS-CoV-2 fecal Gastrointestinal symptom global pandemic Gut Gut barrier gut barrier integrity include increasing age insight integrated stress responses metabolic stress novel coronavirus disease Public pulmonary system receptor response responses SARS-CoV-2 SARS-CoV-2 receptor Stress susceptibility transcriptomic viral entry virus vomiting [DOI] 10.3389/fmed.2020.606991 PMC 바로가기 [Article Type] Medicine
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectivenessResearch Article Published on 2020-12-212022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] acute viral infection Administered antiviral drug Cell Cellular immune response cellular mechanism clearance clinical effectiveness Combination component COVID-19 decrease disease Disease progression dosage drug Effect effective Effectiveness epithelial epithelial cell exhibit faster Hepatitis High dose immune immune response immune-cell Infection infection mechanism Interaction interfere less low dose mechanisms multicellular multiple groups outcome outcomes platform Potential treatment primary viral infection progression promote prophylactically recruitment reduce reduced Remdesivir Replication rate Repository Side effect Simulation spatiotemporal Support susceptibility Therapies therapy tissue tissue damage tissues Treatment viral infection Viral RNA virus virus replication viruses widespread [DOI] 10.1371/journal.pcbi.1008451 PMC 바로가기 [Article Type] Research Article
Corticosteroid therapy in critically ill patients with COVID-19: a multicenter, retrospective studyCOVID-19 중증 환자의 코르티코스테로이드 요법: 다기관, 후향적 연구Multicenter Study Published on 2020-12-182022-09-11 Journal: Critical Care [Category] MERS, 변종, [키워드] 95% CI adjusted Administered affected Analysis applied association baseline clearance confounding factor confounding factors correlation Corticosteroid corticosteroid treatment Corticosteroids COVID-19 Cox proportional-hazards model Critically ill Critically ill patient critically ill patients Efficacy evaluate ICU ICU admission investigated Logistic regression Marginal structural modeling Methylprednisolone Mortality multicenter not performed outcome Patient performed recruited Result Retrospective study SARS-CoV-2 RNA severe COVID-19 Severe patient severe patients Stratification stratified subgroup analysis therapy treated Treatment variables was performed with COVID-19 [DOI] 10.1186/s13054-020-03429-w PMC 바로가기 [Article Type] Multicenter Study
Potential Mechanisms for Traditional Chinese Medicine in Treating Airway Mucus Hypersecretion Associated With Coronavirus Disease 2019Molecular Biosciences Published on 2020-12-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Affect airway Airway mucus Algorithm Analysis applied association binding Bioconductor biological basis Bronchiole Chinese clearance collected complications Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient Critical cytokine receptor cytokine-related pathways Cytoscape software death Deterioration dysfunction expectorant formulae Frequency functional enrichment Health hypersecretion Hypoxemia ingredient Interaction MAPK mechanism mechanisms Medicine modulating Mortality mucins Mucus NCBI network analysis network pharmacology objective pandemic pathway Potential PPI Protein Receptor binding regulate Result retrieved subsequent target targets TCM TCMSP database Therapies Traditional Traditional Chinese medicine treating treating COVID-19 Treatment was done [DOI] 10.3389/fmolb.2020.577285 PMC 바로가기 [Article Type] Molecular Biosciences
Novel Use of Premixed Dialysate Bags during Water Supply Interruption in Acute Hospital Setting급성 병원 환경에서 물 공급 중단 시 사전 혼합된 투석액 백의 새로운 사용Article Published on 2020-12-092022-08-31 Journal: Kidney360 [Category] MERS, SARS, 치료제, [키워드] acute dialysis acute hospital addition Bag changes in clearance Critical dependent on dialysate dialysis dialysis solutions failure flow rate Hemodialysis hospital hyperkalemia indications Inpatient Inpatients interruption methodology mitigate MONITOR natural disasters novel occurred pandemic Patient patient safety pre-mixed dialysate problem Recognition recognize Regulation Safe SARS-CoV-2 pandemic setting supply the patient the SARS-CoV-2 Treatment Ultrafiltration Volume water water quality water quality for dialysis Water Supply [DOI] 10.34067/KID.0004762020 PMC 바로가기 [Article Type] Article