Diffuse pneumonitis from coronavirus HKU1 on checkpoint inhibitor therapyCase Report Published on 2020-05-192022-10-30 Journal: Journal for immunotherapy of cancer [Category] COVID-19, MERS, [키워드] acute respiratory syndrome adverse event association Brain case reports coronavirus Coronavirus infection COVID-19 pandemic CT scan diagnosed diffuse Dyspnea early-onset evidenced exacerbated ground glass HKU1 Immune-mediated immunomodulation Immunotherapy Infection inhibitor Interaction Ipilimumab Melanoma nivolumab Non-COVID-19 Patient SARS-CoV-2 severity steroid therapy Toxicity treated [DOI] 10.1136/jitc-2020-000898 PMC 바로가기 [Article Type] Case Report
The daily impact of COVID-19 in gastroenterologyReview Articles Published on 2020-04-112022-10-29 Journal: United European gastroenterology journal [Category] COVID-19, SARS, [키워드] absence Cluster Contact Contamination coronavirus Corticosteroid COVID-19 dose effective endoscopy Epidemic Epidemiology evidenced Evolution Factors gastroenterology General population healthcare IBD immunology immunomodulatory immunosuppressive increased risk Inflammatory bowel disease new strain pandemic Patient patients with pneumonia potential risk provided recommendation reduce mortality reduced Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission susceptibility suspected patient the disease Transmission Treatment Vaccines virus spread Wuhan, China [DOI] 10.1177/2050640620920157 PMC 바로가기 [Article Type] Review Articles
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational developmentResearch paper Published on 2020-04-022022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV agonists antibody antigen-specific antibody building characteristic clinical development clinical trials coronavirus Coronavirus infection COVID-19 COVID-19 disease COVID-19 vaccines develop Diseases domain effort elicited ELISA evidenced finding fused Health immune immune response immunization immunogenicity in vivo induce infectious agent injection long-lasting MERS MERS-CoV MERS-CoV S1 MERS-CoV vaccine MERS-CoV vaccines mice Microneedle microneedle array Middle East MNA MOST Novel coronavirus Outbreaks Pandemics produced Progressive Protein protein subunit vaccine respiratory response responses SARS-CoV SARS-CoV-2 SARS-CoV-2 S1 sequence serum specific IgG antibody subcutaneously Subunit vaccine subunit vaccines Support tested the SARS-CoV-2 TLR4 TLR5 translational trimeric trimerization Vaccine variant viral envelope virus virus neutralization assays [DOI] 10.1016/j.ebiom.2020.102743 PMC 바로가기 [Article Type] Research paper
Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysisResearch Article Published on 2019-07-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] acute diarrhea acute respiratory syndrome Analysis animal model approach automated Biosafety Level 3 blood draw complete blood count coronavirus CoV CoVs days post infection differential diagnosis Dipeptidyl peptidase 4 Disease progression disease severity dose DPP4 driving entry receptor evidenced Factor flow cytometry fluctuation Health hematological highlighting Host humans Inclusion increase Increasing kinetic leukocyte population leukocytes lung lymphopenia Major measure MERS coronavirus MERS-CoV MERS-CoV infection mice Middle East modulated modulation mouse model neutrophil count Pathogenesis peaked Peripheral blood Predictive SARS-CoV syndrome the United State translation utility Vaccine viral pathogen viral pathogenesis virus weight loss [DOI] 10.1371/journal.pone.0220126 PMC 바로가기 [Article Type] Research Article
Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector FunctionImmunology Published on 2019-04-102022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] ameliorated caused CD11b Cell cytokine cytotoxicity deficiency degranulation development domain effector evidenced exhibited expressed expression fulminant hepatitis function granzyme B Hepatitis hepatitis B homologous identify IFN-γ Immune-mediated in vitro Infection investigated Kctd9 knockout mice Lineage liver Liver damage manifested maturation mechanism mice murine hepatitis virus natural natural killer NK cell NK cell function NK cells Patient phenotype potassium channel progression proliferative proportion reduction in Regulation selective supported survival transcription factors tumor cell wild-type [DOI] 10.3389/fimmu.2019.00744 PMC 바로가기 [Article Type] Immunology
Evaluation of the efficacy of a commercial inactivated genogroup 2b-based porcine epidemic diarrhea virus (PEDV) vaccine and experimental live genogroup 1b exposure against 2b challengeResearch Article Published on 2017-10-262022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] age Antibody Response Cluster condition detectable Efficacy epidemic diarrhea evidenced fecal FIVE groups IgA IgA level IgA response IgG level inactivated Inactivated vaccine intramuscular less Live virus log naïve pathogenic PEDV pig PROTECT randomly divided reduction RNA significantly higher significantly lower Vaccine viral shedding virus virus strain [DOI] 10.1186/s13567-017-0472-z PMC 바로가기 [Article Type] Research Article
Microglia Play a Major Role in Direct Viral-Induced DemyelinationResearch Article Published on 2013-06-202022-10-31 Journal: Clinical and Developmental Immunology [Category] Coronavirus, [키워드] activate activated Activation Acute inflammation Antigen presentation APC calcium-binding protein cause cellular Central nervous system changes in characteristic chronic inflammation CNS Culture current demonstrated Demyelination Direct evidenced Ex vivo function in vitro increased expression infect Infected Infection Inflammatory Injury involved Major membrane MHV microglia microglial morphology mouse hepatitis virus multiple sclerosis myelin sheath Neonatal Neurological disease neurotropic performed phagocytosis Population Postinfection previous study Proteins role subsequent suggested turn [DOI] 10.1155/2013/510396 PMC 바로가기 [Article Type] Research Article
Mixed infections with Chlamydia and porcine epidemic diarrhea virus – a new in vitro model of chlamydial persistenceResearch Article Published on 2010-07-272022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] Alter appear Cell cells Chlamydia Chlamydiaceae Chlamydiae chronic disease Co-infection Culture detected developmental elementary body epidemic diarrhea evidenced experiment experiments heterogenous homogenous hpi Human Hypothesis immunofluorescence in vitro in vitro model Inclusion induce Infection infections investigated mixed infection NO observation PEDV persistence produced Re-infection Result TEM transmission electron microscopy Vero Cell virus [DOI] 10.1186/1471-2180-10-201 PMC 바로가기 [Article Type] Research Article
Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic CellsResearch Article Published on 2008-07-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activated activity Antibody Response baculovirus baculovirus bat CD4+ T cell CD40 CD80 CD83 CD86 co-stimulatory molecule compared CoV cytokine Cytokines DC DCs demonstrated dendritic cell different DNA DNA vaccine evidenced Express expression finding Human IL-10 IL-6 immature incorporation indicated information inoculated insect cell labeling led to M protein membrane membrane protein mice Microscopy origin Particle Pathogenesis Population Protein response S protein SARS Coronavirus SARS CoV SARS-CoV SARS-CoV S SARS-like coronavirus secretion SL-CoV stimulate Stimulating T cell response the S protein TNF-α up-regulated Vaccine development Virus-like particle VLP VLPs western blot [DOI] 10.1371/journal.pone.0002685 PMC 바로가기 [Article Type] Research Article