homologous – Page 26 – Communicable Diseases Research

Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania

실험 하이브리드의 전체 게놈 시퀀싱은 Leishmania에서 감수 분열과 같은 성적 재조합을 지원합니다

Research Article

Published on 2019-05-152022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function

Immunology

Published on 2019-04-102022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, MERS,

[키워드] ameliorated caused CD11b Cell cytokine cytotoxicity deficiency degranulation development domain effector evidenced exhibited expressed expression fulminant hepatitis function granzyme B Hepatitis hepatitis B homologous identify IFN-γ Immune-mediated in vitro Infection investigated Kctd9 knockout mice Lineage liver Liver damage manifested maturation mechanism mice murine hepatitis virus natural natural killer NK cell NK cell function NK cells Patient phenotype potassium channel progression proliferative proportion reduction in Regulation selective supported survival transcription factors tumor cell wild-type
[DOI] 10.3389/fimmu.2019.00744 PMC 바로가기 [Article Type] Immunology

Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens

Article

Published on 2019-02-212024-08-28
Journal: Infection and Immunity [Category] 말라리아,

[키워드] antibodies CHMI CSP Heterologous homologous malaria Msp-1 Plasmodium falciparum Plasmodium vivax

Effect of Pullet Vaccination on Development and Longevity of Immunity

Article

Published on 2019-02-022022-10-28
Journal: Viruses [Category] Coronavirus,

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

Research Article

Published on 2018-09-242022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자,

[키워드] Amino acid antagonist Antiviral effect approach assumed bats binding Calu-3 Cell cells cellular cleave clone competent conserved coronavirus Coronaviruses CoV determine domain early stage enzyme Epidemic event expected function functional Genetic genetics Genome homologous Host human airway epithelial identify identity IFN immune independent Infection knowledge Lineage novel pandemic Papain-like protease pathogen plethora PLP polyprotein predict Protein Proteins replicated Research reservoir resulting SARS-coronavirus SARS-CoV sequencing technology supported suppressed Surveillance the epidemic the interferon Variability variant Vero Cell viral genome viral lineage virulence virulent virus viruses zoonotic zoonotic spillover
[DOI] 10.1371/journal.ppat.1007296 PMC 바로가기 [Article Type] Research Article

Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In Vivo

Vaccines and Antiviral Agents

Published on 2018-09-122022-10-30
Journal: Journal of Virology [Category] Coronavirus, MERS,

[키워드] avian infectious bronchitis virus BeauR bronchitis cause cellular challenge Characteristics characterized chimeric ciliary Clinical sign Clinical signs conducted conformational contagious coronavirus cross-protection determine expressing glycoprotein Heterologous homologous IBV IMPROVE in vitro in vivo induce Limited Live attenuated vaccines M41 mucosal tissue Partial partial protection PROTECT protective immunity recombinant recombinant vaccine reduction in reductions in replicated Replication Respiratory disease responsible rIBV S1 S1 and S2 S2 subunit serotype serum serum antibody single vaccination spike strain surface protein the S1 subunit tracheal Trial vaccination Vaccine Viral load viral RNA load virulent virus
[DOI] 10.1128/JVI.01473-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

Research Article

Published on 2018-05-222022-10-29
Journal: mBio [Category] Coronavirus, MERS, SARS,

Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways

Research Article

Published on 2017-08-302022-10-28
Journal: Veterinary Research [Category] Coronavirus,

[키워드] aa deletion absence activate affected Analysis Apoptosis arginine cellular Characteristics Comparative conserved E protein eight envelope protein epidemic diarrhea ER stress expression Frame functional protein Genes genomic variation glycine GRP78 homologous host cell identification IL-6 IL-8 independent induce Infection membrane fusion morphology Mutation pathway PEDV potential mechanism pro-inflammatory cytokine proliferate proliferation protease Protein Receptor binding Replication responsible S2′ cleavage screened single mutation strain supplementary material transmembrane domain trypsin Variation Vero cells virion virus virus titer whole genome sequence α-coronavirus
[DOI] 10.1186/s13567-017-0449-y PMC 바로가기 [Article Type] Research Article

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A , -B and -C alleles

10,000개 이상의 HLA-A, -B 및 -C 대립유전자 서열의 무작위 변이로부터 기능적 다형성 구별

Research Article

Published on 2017-06-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] allele alleles amino-acid Analysis Antigen applicability binding site bone-marrow transplant bone-marrow transplants breadth common allele common alleles core alleles Defense determined by develop distinguishing domain Donor donors effort engage exponential growth Facilitating Families family family member Frequency functional Genetic variation glycoprotein growth HLA HLA class I HLA class I alleles HLA class I glycoproteins HLA complex HLA gene HLA genes HLA type HLA variation HLA-A HLA-B HLA-C HLA-C alleles homologous human gene human genes Human genome human population human populations immune functions immune reaction immune system genes incidence individuals Infection kill lymphocyte majority MOST Mutation mutation rate nucleotide nucleotides Older Patient peptide peptides Point mutation polymorphism populations Positive selection predict produced random receptors recombinant recombinants registries required selected sequence sequenced Sequencing Single nucleotide polymorphism single nucleotide polymorphisms Spread subject Substitution the patient variant variants Variation Viral viral infections
[DOI] 10.1371/journal.pgen.1006862 PMC 바로가기 [Article Type] Research Article

Safety and immunogenicity of a parenteral P2-VP8-P[8] subunit rotavirus vaccine in toddlers and infants in South Africa: a randomised, double-blind, placebo-controlled trial

남아프리카 공화국의 유아 및 유아에 대한 비경구 P2-VP8-P[8] 서브유닛 로타바이러스 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조 시험

Articles

Published on 2017-05-052022-09-06
Journal: The Lancet. Infectious Diseases [Category] Communicable Disease,

[키워드] 95% CI adjusted adverse event adverse events African approach assigned benefit block Block randomisation Cohort computer-generated different dose different doses dose dose-escalation doses double-blind eligible Endpoint enrolled finding FIVE followed by foundation Frequency funding geometric mean geometric mean titre geometric mean titres groups healthy highest HIV-uninfected homologous hospital IgA IgG IgG seroresponse immunogenic immunogenicity Infant Infants injection Injections Laboratory live oral rotavirus vaccines Local Melinda Gate Melinda Gates Mild neutralising antibody neutralising antibody seroresponse neutralising antibody seroresponses nine non-replicating rotavirus vaccine occurred offer oral rotavirus vaccine oral vaccines parent Parenteral parents participant Placebo placebo group placebo-controlled placebo-controlled trial primary immunogenicity randomisation randomised reaction receiving reduced Registered Research rotavirus rotavirus disease rotavirus vaccination rotavirus vaccine Safety safety analysis safety endpoint Serious Adverse Event Serious Adverse Events Serum IgA seroresponse Serum IgA seroresponses Seven severity South South Africa subunit Subunit vaccine systemic reaction systemic reactions the placebo group those receiving placebo Treatment Trial trivalent vaccination Vaccine was done was used
[DOI] 10.1016/S1473-3099(17)30242-6 PMC 바로가기 [Article Type] Articles