interfere – Page 26 – Communicable Diseases Research

Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections

Review

Published on 2020-06-302022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Aromatic Herbs, Medicinal Plant-Derived Essential Oils, and Phytochemical Extracts as Potential Therapies for Coronaviruses: Future Perspectives

Review

Published on 2020-06-262022-10-28
Journal: Plants [Category] COVID-19,

[키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection addition Antiviral antiviral activity antiviral drugs Antiviral treatment approved drug aromatic China Compound compounds coronavirus 2 Coronavirus infection Coronaviruses COVID-19 CoVs develop discharge drugs Effects Essential essential oils Extract Future herbal medicine herbal medicines Host in vitro in vivo interfere interferon Intervention mechanism medicinal plants MERS-CoV novel antiviral drugs Numerous outbreak Patient phytochemical phytochemicals plants Pneumonia Potential predicted Replication respiratory SARS-CoV SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Side effects Spread targets therapeutic use Therapies Treatment Vaccine Vaccines viral entry viral life cycle Viral resistance virus Wuhan
[DOI] 10.3390/plants9060800 PMC 바로가기 [Article Type] Review

The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial

Letter

Published on 2020-06-082022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] 1:1 48 hour 48 hours Activation Administered adverse event African age allergy analyzed Angola Antiviral approved ARMS Barcelona baseline blinded block Cerebrovascular disease chain chest X-ray childbearing chronic clinical care clinical trial co-morbidity conducted contraceptive method control group coronary disease cough country COVID-19 COVID-19 disease COVID-19 patient criteria Critical current CYP3A4 death detectable determine diagnosed with COVID-19 disease dissemination dose double-blind drug early treatment Efficacy element Endemic EudraCT excluded eye Factor Fever flow cytometry Follow-up visit Frequency Gabon global health groups history home visit Identified IgA IgA level IgG IgM immune response Immunity immunology immunomodulatory IMPROVE in vivo Infection Inflammatory inhibitor interfere investigator involved Isolation Ivermectin laboratory parameter Loa loa magnitude marker median Nasopharyngeal swab nasopharyngeal swab PCR negative neoplasm Nigeria no risk number objective outcome participant Patient Patient care patients PCR PCR cycle physical Placebo placebo group placebo-controlled Pneumonia positive positive SARS-CoV-2 PCR post-menopausal Potential pregnancy test pregnant women progression proportion protocol public health pulmonary random randomised randomised controlled trial randomization randomization list Randomized Rapid diagnostic test reaction receive recent recruited reduce Registered renal resident risk Ritonavir Safe Sample size SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2-specific T cell secondary sequence Seroconversion severe disease severity single center single dose Spain status Study protocol subject submitted surgical Symptom symptom onset the patient the SARS-CoV-2 threshold transcriptomics Transmission transmission-blocking Travel treated patient treated patients Treatment treatment group Trial unblinding Viral load virus vulnerable population website with mild disease women
[DOI] 10.1186/s13063-020-04421-z PMC 바로가기 [Article Type] Letter

Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review

Review

Published on 2020-06-082022-10-31
Journal: Nutrients [Category] COVID-19, SARS,

A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 48 hour Admission allergic reaction anticipated application AST/ALT Bacterial infection Bacterial infections blinded block Breast feeding clinical clinical trial Combination concealed conducted Contraception Control COVID-19 COVID-19 patient criteria defined dependent on Desirable diagnostic Diaphragm dissemination dose double blind ECMO Efficacy Efficacy and safety element Endpoint evaluate extracorporeal membrane oxygenation failure female Germany Hospital stay Hydroxychloroquine IL-6-Rezeptor blockade Immunosuppression immunosuppressive therapy IMV independent Inflammation ingredient Injury Inpatient intensive care units interfere Invasive mechanical ventilation investigator investigators less life lung failure mechanical ventilation methotrexate NaCl NIV non-invasive ventilation number objective outcome parallel group parameters participant Participation Pathogenesis Patient patients PCT performed placebo-controlled trial Pneumonia polymerase chain positive Prednisolone produced progression proof protocol Pulmonary function pulmonary inflammation Quality of life randomisation randomised randomised controlled trial recruited reduce Registered respiratory Safe Sample size SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection SAS severe COVID-19 Severe COVID-19 pneumonia Simultaneous single dose status stratified Study protocol sulfasalazine System the patient therapy Tocilizumab Treatment Trial trials Tuberculosis ULN unit Ventilation ventilator ventilator free day ventilator free days VFD Viral hepatitis website
[DOI] 10.1186/s13063-020-04447-3 PMC 바로가기 [Article Type] Letter

Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37

비타민 D 결핍과 대기 오염은 항바이러스 펩티드 LL37의 억제를 통해 COVID-19를 악화시킵니다

Public Health

Published on 2020-05-282022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 치료제,

[키워드] acquisition Action African American age Air pollution airway carbon nanoparticles Cathelicidin cathelicidin/LL37 citrullination of peptide cleaved co-morbid condition co-morbid conditions COVID-19 COVID19 cytokine cytokine signaling demonstrated effective exposure to expression generate Genes immune immune system Infection infections influence insufficiency interfere Lung disease microbe microbes modulate modulating modulation morbidity morbidity and mortality outcome Particle Pollution public health threat reduce reduced reducing respiratory Respiratory tract infections risk risk factor Risk factors Safe SARS-CoV-2 severity severity of COVID-19 shown Signaling skin pigmentation smoke stimulate suppression synthesis the disease tobacco smoke Transcription VDD Viral virus viruses Vitamin Vitamin D vitamin D deficiency weakened while
[DOI] 10.3389/fpubh.2020.00232 PMC 바로가기 [Article Type] Public Health

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Research

Published on 2020-05-262022-10-05
Journal: Nature [Category] SARS, 변종,

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

Short Report

Published on 2020-05-262022-10-31
Journal: eLife [Category] COVID-19, MERS, SARS,

[키워드] ACE2 Activation acute respiratory distress syndrome adopted Affect airway Amino acid Analysis block cause Cell cell type cells cellular cleavage cleavage site cleave conditions coronavirus COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patients Critical diagnose dysregulation ENaC enzyme epithelial explain expression global pandemic Health help highlight highlighting homeostasis Host host cell Human human cell human lung human proteins human respiratory cells identify identifying infect interfere lifecycle lung Lungs mechanism molecular mimicry mouse organ overlap pathophysiology patients peptide Prevent protease Protein Proteins proteolytic proteolytic activation receptor ACE2 remained respiratory tract respiratory tract cell resulting RNA-Seq S1/S2 cleavage site SARS-CoV-2 sequence sequenced severe respiratory symptoms sodium spike the SARS-CoV-2 the spike protein treat unique virus
[DOI] 10.7554/eLife.58603 PMC 바로가기 [Article Type] Short Report

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells

대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성

Article

Published on 2020-05-212022-09-10
Journal: Biomedicines [Category] 비임상,

[키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website
[DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

Review

Published on 2020-05-172022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,